OBJECTIVE To explore the association of postoperative urinary tract infections with peripheral blood in-tercellular adhesion molecule-1(ICAM-1)gene polymorphisms in the patients with menopausal stress urinary in-continence.METHODS A total of 132 patients with menopausal stress urinary incontinence who received mid-ure-thral suspension surgery in the Third People's Hospital Affiliated to Fujian University of Traditional Chinese Med-icine from Sep.2020 to Sep.2023 were recruited as the research subjects and were divided into the infection group with 25 cases and the non-infection group with 107 cases according to the status of postoperative urinary tract in-fections.The distribution of pathogens isolated from the infection group was statistically analyzed.The peripheral blood ICAM-1 gene polymorphisms and the levels of soluble triggering receptor expressed on myeloid cells(sTREM-1),high-mobility group box 1(HMGB1)and monocyte chemoattractant protein-1(MCP-1)were ob-served and compared between the two groups.The values of the three markers in diagnosis of the postoperative u-rinary tract infections in the patients with menopausal stress urinary incontinence were analyzed.RESULTS Totally 34 strains of pathogens were isolated from the 25 patients of the infection group,21(61.76％)of which were gram-negative bacteria,Escherichia coli(11 strains,32.35％)was the predominant species of the gram-negative bacteria.The frequencies of KK genotype at K469E locus of ICAM-1 gene and K allele of the infection group were higher than those of the non-infection group,while the frequencies of EE genotype and E allele of the infection group were lower than those of the non-infection group(P＜0.05).There were significant differences in the levels of serum sTREM-1,HMGB1 and MCP-1 between the infection group and the non-infection group(P＜0.05);the MCP-1 level of the infection group was(63.68±20.63)pg/ml,higher than that of the non-infection group(t=6.472,P＜0.001).The area under the curve(AUC)value of the single detection of the three markers was lower in diagnosis of the postoperative urinary tract infections in the patients with menopausal stress urinary in-continence than that of the joint detection of the three markers(P＜0.05).CONCLUSIONS The gram-negative bacteria are dominant among the pathogens isolated from the menopausal stress urinary incontinence patients with postoperative urinary tract infections.The patients show the increased expressions of sTREM-1,HMGB1 and MCP-1;the joint detection of the three markers has more advantages in auxiliary diagnosis of the postoperative u-rinary tract infections.The susceptibility to the postoperative urinary tract infections is associated with the ICAM-1 gene polymorphisms.

OBJECTIVE To explore the association of postoperative urinary tract infections with peripheral blood in-tercellular adhesion molecule-1(ICAM-1)gene polymorphisms in the patients with menopausal stress urinary in-continence.METHODS A total of 132 patients with menopausal stress urinary incontinence who received mid-ure-thral suspension surgery in the Third People's Hospital Affiliated to Fujian University of Traditional Chinese Med-icine from Sep.2020 to Sep.2023 were recruited as the research subjects and were divided into the infection group with 25 cases and the non-infection group with 107 cases according to the status of postoperative urinary tract in-fections.The distribution of pathogens isolated from the infection group was statistically analyzed.The peripheral blood ICAM-1 gene polymorphisms and the levels of soluble triggering receptor expressed on myeloid cells(sTREM-1),high-mobility group box 1(HMGB1)and monocyte chemoattractant protein-1(MCP-1)were ob-served and compared between the two groups.The values of the three markers in diagnosis of the postoperative u-rinary tract infections in the patients with menopausal stress urinary incontinence were analyzed.RESULTS Totally 34 strains of pathogens were isolated from the 25 patients of the infection group,21(61.76％)of which were gram-negative bacteria,Escherichia coli(11 strains,32.35％)was the predominant species of the gram-negative bacteria.The frequencies of KK genotype at K469E locus of ICAM-1 gene and K allele of the infection group were higher than those of the non-infection group,while the frequencies of EE genotype and E allele of the infection group were lower than those of the non-infection group(P＜0.05).There were significant differences in the levels of serum sTREM-1,HMGB1 and MCP-1 between the infection group and the non-infection group(P＜0.05);the MCP-1 level of the infection group was(63.68±20.63)pg/ml,higher than that of the non-infection group(t=6.472,P＜0.001).The area under the curve(AUC)value of the single detection of the three markers was lower in diagnosis of the postoperative urinary tract infections in the patients with menopausal stress urinary in-continence than that of the joint detection of the three markers(P＜0.05).CONCLUSIONS The gram-negative bacteria are dominant among the pathogens isolated from the menopausal stress urinary incontinence patients with postoperative urinary tract infections.The patients show the increased expressions of sTREM-1,HMGB1 and MCP-1;the joint detection of the three markers has more advantages in auxiliary diagnosis of the postoperative u-rinary tract infections.The susceptibility to the postoperative urinary tract infections is associated with the ICAM-1 gene polymorphisms.

The incidence of osteoporotic thoracolumbar vertebral fracture (OTLVF) in the elderly is gradually increasing. The kyphotic deformity caused by various factors has become an important characteristic of OTLVF and has received increasing attention. Its clinical manifestations include pain, delayed nerve damage, sagittal imbalance, etc. Currently, the definition and diagnosis of OTLVF with kyphotic deformity in the elderly are still unclear. Although there are many treatment options, they are controversial. Existing guidelines or consensuses pay little attention to this type of fracture with kyphotic deformity. To this end, the Lumbar Education Working Group of the Spine Branch of the Chinese Medicine Education Association and Editorial Committee of Chinese Journal of Trauma organized the experts in the relevant fields to jointly develop Clinical guidelines for the diagnosis and treatment of osteoporotic thoracolumbar vertebral fractures with kyphotic deformity in the elderly ( version 2024), based on evidence-based medical advancements and the principles of scientificity, practicality, and advanced nature, which provided 18 recommendations to standardize the clinical diagnosis and treatment.

Objective: To explore the impact of nuclear factor-kappa B (NF-κB) in patients with left-to-right shunt congenital heart disease (CHD) combining pulmonary arterial hypertension (PAH) and its clinical signiifcance. Methods: A total of 78 relevant patients were enrolled in this study. According to mean pulmonary artery pressure (mPAP) measured during operation, the patients were divided into 4 groups: Non-PAH group, the patients with mPAP≤25 mmHg,n=20, Mild PAH group, 25 mmHg mPAP≤35 mmHg,n=21, Moderate PAH group, 35 mmHg45 mmHg,n=23. 2 mL pulmonary artery blood was taken from each patient and plasma level of NF-κB was measured by ELISA to study the relationship between NF-κB and mPAP. Results: Pulmonary arterial plasma levels of NF-κB were increased accordingly as in Non-PAH group was (180.59 ± 10.16) ng/L, in Mild PAH group was (572.83 ± 34.80) ng/L, in Moderate PAH group was (980.85 ± 24.95) ng/L and in Severe PAH group was (1 253.4 ±130.8) ng/L, allP<0.01; NF-κB level was positively related to mPAP (r=0.856,P<0.01). Conclusion: Plasma level of NF-κB was involved in the pathological physiology process of left-to-right shunt CHD combining PAH, it couldbe used as one of the references for distinguishing the severity of PAH and for monitoring the dynamic changes of PAH in relevant patients.