AIMTo explore the influence of hyperbaric oxygen (HBO) preconditioning on anoxic resistance and anti-weariness at high altitude.

METHODS(1) SOD, MDA, NO, NOS, BLA and BUN of 20 youths living at 3 700 m altitude for half year were tested, then they were divided into group A (n=10, received HBO pretreatment twice) and group B (n=10, received HBO pretreatment 5 times) randomly. They were asked to pedal the EMG-bicycle-ergometer at the second and eighth day, and then the same items were tested. (2) 29 youth who would go to Astronomical Spot (5200 m) were randomly divided into group HBO (n=11, received HBO pretreatment once per day for 2 days at Yecheng (1400 m)) and comparison group (n=10). When they reached I Astronomical Spot, thematic biochemical index were investigated. (3) When 20 youth reached Thirty Milepost Barracks (3700 m) at the second day in their way to Immortal Gulf (5380 m) from Yecheng were randomly divided into group HBO (n=10, received HBO pretreatment once per day for 3 days) and comparison group (n=10). When they reached Immortal Gulf, the thematic biochemical index were investigated.

RESULTS(1) SOD, NO, NOS were increased and BLA, BUN, MDA were decrease in group A compared with that in group B until the eighth day, there was significant difference (P < 0.01). (2) SOD, NO, NOS were increased and BLA, BUN, MDA were decrease in group HBO compared with that in comparison that in group, there was significant difference between groups (P < 0.01, or P < 0.05).

CONCLUSIONHBO could enhance the activity of anti-oxidase and the cleared ability of lactic acid, and the effect of anti-weariness could last for 8 days.

Altitude ; Altitude Sickness ; prevention & control ; Fatigue ; prevention & control ; Humans ; Hyperbaric Oxygenation ; methods ; Hypoxia ; physiopathology ; Ischemic Preconditioning ; methods ; Male ; Oxidative Stress ; drug effects ; physiology ; Superoxide Dismutase ; metabolism ; Young Adult

Oblective To investigate effects of hyperbaric oxygen(HBO)on brain-body physiological functions of immigrators who immigrated from chafnpaign to different altitude plateau.Methods Sixty-healthy young men who immigrated to 3700 metres plateau before long were selected as subjects.who was 17 to 23 years old(average age 21.3±1.3).Sixty subjects were divided into two groups:one group treated with HBO and another one not treated with HBO.The former was randomly divided into A1(n=20)and B1 groups(n=10),and the latter,A2 group(n=20)and B2 group(n=10).After5 days when the young men in A1 and A2 groups had continued ascending at over 5000 metres altitude(5 100-5380 m),all indexes were examined under the quiescent condition.After 10 minutes when the young men in B1 and B2 groups had done load exercise on the sixth day at 3700 metres altitude,all indexes were examined.DDX-200 computer-aided muhi-function psychological-physiological test machine and YZ-B6 high-light source direct funduscope were used to observe dynamic state of retina,adaptive function of darkness was tested by luminous watch in dark room,and SaO2 was measured by ASC-545 hemo-oxygen equipment.Results Compared with group A2,the correct numbers of right-hand-left-foot-cross and left-hand-right-foot-cross movements in A1 group were significantly more (P＜0.01),and the dark adaptation time,significantly shorter(P＜0.05),and the level of SaO2,significantly higher(P＜0.05).The retinal test results indicated that hypoxia extent in A1 group was lighter than that in A2 group.Compared with B2 group,the correct numbers of right-hand-left-foot-cross and left-hand-right-foot-cross movements in B1 group were significantly more(P＜0.01),the dark adaptation time was significantly shorter (P＜0.05),and the level of SaO2,significantly higher(P＜0.05).The retinal test results indicated that hypoxia extent in B1 group was lighter than that in B2 group.Conclusions HBO could effectively improve brain-body physiological functions of immigrators at altitude of 3700 m and over 5000 m,and effectively relieve hypoxia status.

Oblective To investigate effects of hyperbaric oxygen(HBO)on brain-body physiological functions of immigrators who immigrated from chafnpaign to different altitude plateau.Methods Sixty-healthy young men who immigrated to 3700 metres plateau before long were selected as subjects.who was 17 to 23 years old(average age 21.3±1.3).Sixty subjects were divided into two groups:one group treated with HBO and another one not treated with HBO.The former was randomly divided into A1(n=20)and B1 groups(n=10),and the latter,A2 group(n=20)and B2 group(n=10).After5 days when the young men in A1 and A2 groups had continued ascending at over 5000 metres altitude(5 100-5380 m),all indexes were examined under the quiescent condition.After 10 minutes when the young men in B1 and B2 groups had done load exercise on the sixth day at 3700 metres altitude,all indexes were examined.DDX-200 computer-aided muhi-function psychological-physiological test machine and YZ-B6 high-light source direct funduscope were used to observe dynamic state of retina,adaptive function of darkness was tested by luminous watch in dark room,and SaO2 was measured by ASC-545 hemo-oxygen equipment.Results Compared with group A2,the correct numbers of right-hand-left-foot-cross and left-hand-right-foot-cross movements in A1 group were significantly more (P＜0.01),and the dark adaptation time,significantly shorter(P＜0.05),and the level of SaO2,significantly higher(P＜0.05).The retinal test results indicated that hypoxia extent in A1 group was lighter than that in A2 group.Compared with B2 group,the correct numbers of right-hand-left-foot-cross and left-hand-right-foot-cross movements in B1 group were significantly more(P＜0.01),the dark adaptation time was significantly shorter (P＜0.05),and the level of SaO2,significantly higher(P＜0.05).The retinal test results indicated that hypoxia extent in B1 group was lighter than that in B2 group.Conclusions HBO could effectively improve brain-body physiological functions of immigrators at altitude of 3700 m and over 5000 m,and effectively relieve hypoxia status.

Acclimatization ; physiology ; Adolescent ; Altitude ; Humans ; Male ; Nitric Oxide ; blood ; Nitric Oxide Synthase ; blood ; Oxygen ; physiology ; Pulmonary Gas Exchange ; Young Adult