[Objective]To explore the meaning of"the patients who vomited after taking Zhizichi Decoction should discontinue it",thereby providing evidence-based references for its clinical application.[Methods]By organizing,summarizing,and analyzing the diverse academic viewpoints of past medical practitioners regarding"the patients who vomited after taking Zhizichi Decoction should discontinue it",this study examines the medicinal properties and preparation of Gardenia jasminoides(Zhizi)and Sojae Semen Praeparatum(Douchi)found in mainstream pharmacological texts.It also investigates the specific connotations of"the patients who vomited after taking Zhizichi Decoction should Discontinue it"from three perspectives:drug-induced vomiting,misconceptions,and post-medication reactions,combining insights from ZHANG Zhongjing's original text and relevant medical cases by YE Tianshi.[Results]There are primarily three different academic viewpoints regarding"the patients who vomit after taking Zhizichi Decoction should discontinue it":the drug-induced vomiting theory,the misconceptions theory and the post-medication reaction theory.The drug-induced vomiting theory posits that Zhizi or Douchi can lead to vomiting,vomiting is a method and objective of treatment,categorizing Zhizichi Decoction as an emetic.The misconceptions theory argues that Zhizichi Decoction does not induce vomiting and that"the patients who vomit after taking Zhizichi Decoction should discontinue it"does not align with the original intention of Treatise on Febrile Diseases.The post-medication reaction theory claims that Zhizichi Decoction is not an emetic;rather,vomiting is a post-medication reaction,with the key factor being the stagnation of Qi in the upper-Jiao.Therefore,Zhizi and Douchi are used in combination to create a mild bitter and spicy effect to regulate the ascent and descent of Qi,allowing the stagnated heat to be expelled.[Conclusion]The post-medication reaction theory aligns most closely with ZHANG Zhongjing's original intention.Zhizichi Decoction has the efficacy of dispersing and removing obstruction,it functions by promoting the circulation of Qi through its slightly bitter and mildly spicy properties to regulate the ascent and descent of Qi,clearing stagnated heat,which should be classified as an diffusing formula within the"ten prescriptions".Accurate clinical application of this formula hinges on identifying the pathogenic mechanism of Qi stagnation in the uppert-Jiao.

[Objective]To explore the meaning of"the patients who vomited after taking Zhizichi Decoction should discontinue it",thereby providing evidence-based references for its clinical application.[Methods]By organizing,summarizing,and analyzing the diverse academic viewpoints of past medical practitioners regarding"the patients who vomited after taking Zhizichi Decoction should discontinue it",this study examines the medicinal properties and preparation of Gardenia jasminoides(Zhizi)and Sojae Semen Praeparatum(Douchi)found in mainstream pharmacological texts.It also investigates the specific connotations of"the patients who vomited after taking Zhizichi Decoction should Discontinue it"from three perspectives:drug-induced vomiting,misconceptions,and post-medication reactions,combining insights from ZHANG Zhongjing's original text and relevant medical cases by YE Tianshi.[Results]There are primarily three different academic viewpoints regarding"the patients who vomit after taking Zhizichi Decoction should discontinue it":the drug-induced vomiting theory,the misconceptions theory and the post-medication reaction theory.The drug-induced vomiting theory posits that Zhizi or Douchi can lead to vomiting,vomiting is a method and objective of treatment,categorizing Zhizichi Decoction as an emetic.The misconceptions theory argues that Zhizichi Decoction does not induce vomiting and that"the patients who vomit after taking Zhizichi Decoction should discontinue it"does not align with the original intention of Treatise on Febrile Diseases.The post-medication reaction theory claims that Zhizichi Decoction is not an emetic;rather,vomiting is a post-medication reaction,with the key factor being the stagnation of Qi in the upper-Jiao.Therefore,Zhizi and Douchi are used in combination to create a mild bitter and spicy effect to regulate the ascent and descent of Qi,allowing the stagnated heat to be expelled.[Conclusion]The post-medication reaction theory aligns most closely with ZHANG Zhongjing's original intention.Zhizichi Decoction has the efficacy of dispersing and removing obstruction,it functions by promoting the circulation of Qi through its slightly bitter and mildly spicy properties to regulate the ascent and descent of Qi,clearing stagnated heat,which should be classified as an diffusing formula within the"ten prescriptions".Accurate clinical application of this formula hinges on identifying the pathogenic mechanism of Qi stagnation in the uppert-Jiao.