Objective:To investigate the relationship between changes in total plasma bile acid (TBA) levels and the remission of non-alcoholic fatty liver disease (NAFLD) in patients with obesity after laparoscopic sleeve gastrectomy (LSG).Methods:A retrospective analysis was conducted on clinical data and follow-up information of 20 patients with obesity and NAFLD undergoing LSG in Beijing Shijitan Hospital between Mar to Jun 2022.Results:Postoperative weight loss was significant. Compared to preoperative values, the weight of 20 patients decreased [(115.92±16.13) kg vs. (78.20±7.77) kg, t=15.675, P<0.001]. The BMI also decreased [(40.66±5.18) kg/m2 vs. (27.43±2.22) kg/m2, t=13.230, P<0.001]. The fatty liver index and hepatic steatosis index decreased significantly [(96.34±5.23) vs. (27.96±20.36), t=16.829, P<0.001; (55.15±6.73) vs. (37.55±4.30), t=16.294, P<0.001]. Plasma TBA levels significantly increased [(7.06±2.80) vs. (12.27±3.79) μmol/L, P<0.001]. Indicators related to glucose, lipids, and liver function in patients significantly decreased. Conclusions:LSG can significantly reduce body weight in patients with obesity and NAFLD and improve NAFLD. LSG can increase plasma TBA levels, and the elevation in TBA levels is positively correlated with the degree of NAFLD remission.

Objective:To investigate the relationship between changes in total plasma bile acid (TBA) levels and the remission of non-alcoholic fatty liver disease (NAFLD) in patients with obesity after laparoscopic sleeve gastrectomy (LSG).Methods:A retrospective analysis was conducted on clinical data and follow-up information of 20 patients with obesity and NAFLD undergoing LSG in Beijing Shijitan Hospital between Mar to Jun 2022.Results:Postoperative weight loss was significant. Compared to preoperative values, the weight of 20 patients decreased [(115.92±16.13) kg vs. (78.20±7.77) kg, t=15.675, P<0.001]. The BMI also decreased [(40.66±5.18) kg/m2 vs. (27.43±2.22) kg/m2, t=13.230, P<0.001]. The fatty liver index and hepatic steatosis index decreased significantly [(96.34±5.23) vs. (27.96±20.36), t=16.829, P<0.001; (55.15±6.73) vs. (37.55±4.30), t=16.294, P<0.001]. Plasma TBA levels significantly increased [(7.06±2.80) vs. (12.27±3.79) μmol/L, P<0.001]. Indicators related to glucose, lipids, and liver function in patients significantly decreased. Conclusions:LSG can significantly reduce body weight in patients with obesity and NAFLD and improve NAFLD. LSG can increase plasma TBA levels, and the elevation in TBA levels is positively correlated with the degree of NAFLD remission.

Objective:To present the surgical details of manual double-layer suturing in patients with obesity combined type 2 diabetes mellitus by three-incision laparoscopic single-anastomosis duodenal-jejunal bypass with sleeve gastrectomy .Methods:Clinical data and follow-up information of 52 obesity combined type 2 diabetes mellitus patients (BMI 27.59-43.71 kg/m2) who underwent three-incision laparoscopic single-anastomosis duodenal-jejunal bypass with sleeve gastrectomy from Jan 2019 to Jul 2022 at Beijing Shijitan hospital were retrospectively analyzed.Results:The procedure was successful in all patients. The median operative time was 120 (90, 120) min, and the median intraoperative bleeding was 20.0 (10.0, 27.5) ml. No fistula or serious surgical complications were observed in the patients at 1 month postoperatively. Compared with the preoperative period, the patient's weight decreased [(93.22±15.21) kg vs. (69.97±11.06) kg, t=21.707, P<0.01], BMI decreased [(33.11±4.09) kg/m 2vs. (24.86±2.95) kg/m 2, t=23.224, P<0.01], and the patient's fasting glucose level decreased [9.52 (7.57, 12.96) mmol/L vs. 5.47 (4.66, 6.39) mmol/L, Z=6.11, P<0.01]. The remission rate of various obesity comorbidities was greatly improved. Conclusion:Under the condition of three-incision laparoscopy, the pure manual duodenal and jejunal double-layer suture method is safe, feasible, and effective for patients with obesity combined with type 2 diabetes mellitus.

Objective To investigate the relationship between hepatic venous outflow obstruction (HVOO) and patterns of the hepatic vein (HV) drainage into inferior vena cava (IVC) in piggyback liver transplantation (PBLT).Methods A retrospective analysis on 202 cases of PBLT (from May 2000 to Aug.2015) was conducted.The recipients' patterns of HV drainage into WC and the angle ∠COB between the reconstructed outflow and IVC in the cross section were recorded by preoperative 3D reconstruction.And the lengths and diameters of recipients' HVs were measured during operations.The relationship between the incidence of HVOO and patterns of HV drainage into IVC was analyzed.Results There were 3 patterns of HV drainage into IVC:type Ⅰ (n =136),trunk of left and middle HVs;type Ⅱ (n=52),trunk of right and middle HVs;type Ⅲ (n=14):trunk of three HVs.There was no statistically significant difference within the HVs of each type,when the lengths and diameters were compared respectively.However,the angle ∠COB of type Ⅰ [(164 ±10.14)°] was significantly bigger than type Ⅱ [(44 ± 12.2)°] and type Ⅲ [(96 ± 13.1) °] (P＜0.05).Accordingly,the highest incidence of HVOO (23.5％) was foundin type Ⅰ,followed by type Ⅱ (9.6％),and type Ⅲ had the lowest incidence (7.1 ％) (P＜0.05).The correlation coefficient Cramer's V =0.765.Conclusion This study demonstrated that there was preferable relativity between the HVOO incidence and the patterns of HV drainage into IVC.Type I is more likely to have HVOO.Type Ⅲ is the most ideal one for PBLT.