Objective:To analyze the clinical characteristics and features of patients infected with severe fever with thrombocytopenia syndrome virus (SFTSV).Methods:A retrospective analysis was conducted on the clinical data of 151 patients infected with SFTSV who were admitted to Zhoushan Hospital from January 2012 to January 2024. The patients were divided into two groups based on disease severity: 120 patients in the mild group and 31 patients in the severe group. Data collected included patient demographics (gender and age) and clinical features (such as fever, nausea and vomiting, muscle tremors, abdominal pain and diarrhea, hematemesis, and respiratory failure), as well as length of hospital stay. Laboratory tests included routine blood tests, coagulation indicators, liver and kidney function, and cardiac enzyme levels.Results:There were no statistically significant differences between the mild and severe groups in terms of gender, age, abdominal pain and diarrhea, hematemesis, and respiratory failure symptoms (all P > 0.05). However, the incidences of nausea and vomiting [54.84% (17/31)] and muscle tremors [51.61% (16/31)] were higher in the severe group compared with the mild group [30.83% (37/120) and 21.43% (34/120), χ2 = 6.18, 6.03, both P < 0.05]. The length of hospital stay was longer in the severe group [(16.87 ± 4.76) days] than in the mild group [(9.79 ± 2.54) days, t = 11.27, P < 0.05]. The activated partial thromboplastin time in the severe group [(43.42 ± 34.21) seconds] was longer than that in the mild group [(34.21 ± 5.65) seconds, t = 7.42, P < 0.05]. Additionally, the levels of aspartate aminotransferase [(453.19 ± 43.21) U/L] and alanine aminotransferase [(167.32 ± 35.49) U/L] in the severe group were higher than those in the mild group [(368.81 ± 32.25) U/L, (120.93 ± 28.31) U/L, t = 12.06, 7.70, both P < 0.05]. Furthermore, creatine kinase [(418.34 ± 37.17) U/L] and creatine kinase-MB [(32.51 ± 5.57) U/L] levels were also higher in the severe group compared with the mild group [(345.19 ± 32.06) U/L, (26.38 ± 4.61) U/L, t = 10.95, 6.31, both P < 0.05]. Conclusions:The clinical features of patients with severe SFTSV infection are characterized by a high incidence of nausea and muscle tremors, as well as coagulation abnormality, myocardial injury, and liver function abnormality, all of which are important for clinical consideration.

Objective:To analyze the clinical characteristics and features of patients infected with severe fever with thrombocytopenia syndrome virus (SFTSV).Methods:A retrospective analysis was conducted on the clinical data of 151 patients infected with SFTSV who were admitted to Zhoushan Hospital from January 2012 to January 2024. The patients were divided into two groups based on disease severity: 120 patients in the mild group and 31 patients in the severe group. Data collected included patient demographics (gender and age) and clinical features (such as fever, nausea and vomiting, muscle tremors, abdominal pain and diarrhea, hematemesis, and respiratory failure), as well as length of hospital stay. Laboratory tests included routine blood tests, coagulation indicators, liver and kidney function, and cardiac enzyme levels.Results:There were no statistically significant differences between the mild and severe groups in terms of gender, age, abdominal pain and diarrhea, hematemesis, and respiratory failure symptoms (all P > 0.05). However, the incidences of nausea and vomiting [54.84% (17/31)] and muscle tremors [51.61% (16/31)] were higher in the severe group compared with the mild group [30.83% (37/120) and 21.43% (34/120), χ2 = 6.18, 6.03, both P < 0.05]. The length of hospital stay was longer in the severe group [(16.87 ± 4.76) days] than in the mild group [(9.79 ± 2.54) days, t = 11.27, P < 0.05]. The activated partial thromboplastin time in the severe group [(43.42 ± 34.21) seconds] was longer than that in the mild group [(34.21 ± 5.65) seconds, t = 7.42, P < 0.05]. Additionally, the levels of aspartate aminotransferase [(453.19 ± 43.21) U/L] and alanine aminotransferase [(167.32 ± 35.49) U/L] in the severe group were higher than those in the mild group [(368.81 ± 32.25) U/L, (120.93 ± 28.31) U/L, t = 12.06, 7.70, both P < 0.05]. Furthermore, creatine kinase [(418.34 ± 37.17) U/L] and creatine kinase-MB [(32.51 ± 5.57) U/L] levels were also higher in the severe group compared with the mild group [(345.19 ± 32.06) U/L, (26.38 ± 4.61) U/L, t = 10.95, 6.31, both P < 0.05]. Conclusions:The clinical features of patients with severe SFTSV infection are characterized by a high incidence of nausea and muscle tremors, as well as coagulation abnormality, myocardial injury, and liver function abnormality, all of which are important for clinical consideration.

Objective: To execute a hierarchical cluster of clinical laboratory indicators in patients with bunyavirus infection. Methods: From July 2015 to July 2017, 14 patients with bunyavirus infection in Zhoushan Hospital were selected.The blood routine, coagulation function and biochemical indicators were detected.Cluster analysis and grouping were carried out by hierarchical clustering method. Results: Hierarchical clustering classification was eventually divided into 2 cases of A category[with TT high and BNP high as the main characteristics(TThighBNPhigh)] and 12 cases of B category[with TT low and BNP low as the main characteristics (TTlowBNPlow)]. The days of hormone drugs and dosage of hormone drugs in A category were (7.43±3.53)d, (489.19±173.02)mg, respectively, which were higher than those in B category[(5.20±1.03)d and (115.11±46.58)mg], the differences were statistically significant(t=2.76, 55.56, all P<0.05). Conclusion It needs probably to pay more days and dose of hormonal drugs for patients with TThighBNPhigh.

Objective: To investigate the clinical value of biochemical indicator and hepatic fibrosis in differential diagnosis of patients with cirrhosis and chronic liver failure. Methods: From December 2015 to December 2018, 30 patients with cirrhosis and 30 patients with chronic liver failure in Zhoushan Hospital were selected.The serum levels of ALT, AST, TBil, hyaluronic acid (HA), laminin (LN), PC-Ⅲ, collagen type Ⅳ(Ⅳ-C) were detected. Results: The serum levels of ALT, AST and TBil in patients with cirrhosis were significantly lower than those in patients with chronic liver failure[(258.17±88.19)U/L vs.(818.37±375.83)U/L; (256.57±97.21)U/L vs.(738.63±329.68)U/L; (51.37±22.13)μmol/L vs.(157.27±85.60)μmol/L, t=-7.95, -7.68, -6.56, all P<0.01]. The serum levels of HA, LN, PC-Ⅲ and Ⅳ-C in patients with cirrhosis were significantly higher than those in patients with chronic liver failure[(433.10±214.39)μg/L vs.(81.56±27.80)μg/L; (157.67±52.60)μg/L vs.(66.06±24.06)μg/L; (126.63±35.24)μg/L vs.(70.96±19.71)μg/L; (162.26±53.93)μg/L vs.(76.13±27.90)μg/L, t=8.90, 8.67, 7.49, 7.76, all P<0.01]. When patients with chronic liver failure were set as state variable, AUC of ALT(0.973) was the highest in ALT, AST, TBil.When patients with cirrhosis were set as state variable, AUC of HA(0.993) was the highest in HA, LN, PC-Ⅲ and Ⅳ-C. Conclusion ALT and HA are suitable for differential diagnosis of patients with cirrhosis and chronic liver failure.