BACKGROUND AND OBJECTIVES: Dysregulation of histone deacetylase expression and enzymatic activity is associated with a number of diseases. It has been reported that protein levels of histone deacetylase (HDAC)1 and HDAC5 increase during human pulmonary hypertension, and that the enzymatic activity of HDAC6 is induced in a chronic hypertensive animal model. This study investigated the protein expression profiles of class I and II a/b HDACs in three systemic hypertension models. SUBJECTS AND METHODS: We used three different hypertensive animal models: (i) Wistar-Kyoto rats (n=8) and spontaneously hypertensive rats (SHR; n=8), (ii) mice infused with saline or angiotensin II to induce hypertension, via osmotic mini-pump for 2 weeks, and (iii) mice that were allowed to drink L-N(G)-nitro-L-arginine methyl ester (L-NAME) to induce hypertension. RESULTS: SHR showed high systolic, diastolic, and mean blood pressures. Similar increases in systolic blood pressure were observed in angiotensin II or L-NAME-induced hypertensive mice. In SHR, class IIa HDAC (HDAC4, 5, and 7) and class IIb HDAC (HDAC6 and 10) protein expression were significantly increased. In addition, a HDAC3 protein expression was induced in SHR. However, in L-NAME mice, class IIa HDAC protein levels (HDAC4, 5, 7, and 9) were significantly reduced. HDAC8 protein levels were significantly reduced both in angiotensin II mice and in SHR. CONCLUSION: These results indicate that dysregulation of class I and class II HDAC protein is closely associated with chronic hypertension.
Angiotensin II ; Animals* ; Blood Pressure ; Histone Deacetylases* ; Histones* ; Humans ; Hypertension ; Hypertension, Pulmonary ; Mice ; Models, Animal* ; NG-Nitroarginine Methyl Ester ; Rats ; Rats, Inbred SHR

To investigate the prevalence of severe fever with thrombocytopenia syndrome virus (SFTSV) in quest and fed ticks in Yanbian area,Jilin province,we collected ticks from 8 counties (cities) from Yanbian area and submitted to test through real time RT-PCR targeting M segment of SFTSV after morphological identification.Bi-directional sequencing were also performed on the amplicons to conduct phylogenetic analysis.As the results,from April to September 2016,a total of 3 446 ticks,including 763 Dermacentor silvarum,222 Haemaphysalis concinna,639 Hae.japonica,515 Hae.longicornis,1 014 Ixodes persulcatus,were harvested.Among 1 605 ticks tested,the minimal infection rate was 8.65% for Hae.concinna,4.53% for Hae.japonica,1.59% for Hae.longicornis,and 3.2% for Haemaphysalis spp.respectively.Sequence analysis from 1 pool of Hae.longicornis showed that M segment of the SFTS viruses shares highly homologous (99%) with those isolated from patients in other provinces of China.Phylogenetic analyze showed that the SFTSV belongs to the same branch with those isolated from patients in Zhejiang Province (2012),and from Hae.longicornis infested on patients in Korea (2013) The SFTS virus obtained from Hae.longicornis in Yanbian area,Jilin,was proposed as YBHC-tick1-Jilin/China.

Coronary artery fistula (CAF) with giant aneurysm and accompanied by coronary artery stenosis is a very rare disease. Herein, we report a case of a 76-year-old woman having a complex coronary-to-pulmonary artery fistula associated with a giant aneurysm and accompanied by coronary artery stenosis. The patient was successfully treated using transcatheter coil embolization and coronary stent implantation. Eight years later, we performed a follow-up coronary angiogram, which revealed the CAF and the aneurysm were completely occluded and previous stent patency.
Aged ; Aneurysm* ; Arteries ; Arteriovenous Fistula ; Coronary Aneurysm ; Coronary Stenosis* ; Coronary Vessels* ; Embolization, Therapeutic ; Female ; Fistula* ; Follow-Up Studies ; Humans ; Rare Diseases ; Stents*

Acute myocardial infarction is a rare but potentially lethal complication of systemic lupus erythematosus. There are several proposed mechanisms for acute myocardial infarction in lupus patients: atherosclerosis and endothelial injury leading to plaque rupture, coronary vasculitis and inflammation of the vessel wall causing aneurismal dilatation or spasm, and acute thrombosis and embolism. We report a-37-year-old man with systemic lupus erythematosus who developed myocardial infarction twice. Potential mechanisms for acute myocardial infarction for this patient are discussed in this report.
Atherosclerosis ; Dilatation ; Embolism and Thrombosis ; Humans ; Inflammation ; Lupus Erythematosus, Systemic* ; Male* ; Myocardial Infarction* ; Percutaneous Coronary Intervention* ; Rupture ; Spasm ; Vasculitis

Transplantation of engineering cartilage is a better choice for the treatment of articular cartilage lesions.Constructing engineering cartilage needs seeded cells and scaffold materials.The property of scaffold materials has a great influence on the biomechanical features of engineering cartilage.A variety of materials can be used for constructing engineering cartilaginous framework.Exploring the research development of scaffold materials and comparing the effects of their clinical applications is of great significance for further improvement of biomechanical characteristics of the engineering cartilage.