Objective To discuss and analyze the clinical effects and value of systemic nursing intervention on constipation in senile patients with multiple fracture of extremities .Methods Retrospective analysis was made on the 360 cases of constipation in se-nile patients with multiple fracture of extremities admitted into hospital for treatment from January 2007 to December 2013.One hundred and eighty patients admitted into hospital from January 2007 to December 2010 were assigned as the control group , while another 180 patients admitted into hospital from January 2011 to December 2013 were assigned as the observation group .The control group was given routine nursing , while the observation group received systemic nursing intervention in addition to routine nursing .Comparison and anal-ysis were made in total satisfaction of nursing on the part of the family dependants , the time of constipation symptom relief , the time of signs relief , the scores of life function and overall life quality , as well as psychological state , were compared between the 2 groups after treatment and nursing .Results Results indicated that total satisfaction of the observation group on the part of family dependents were higher than that of the control group , and statistical significance could be seen , when comparisons were made between the 2 groups ( P<0.05).The time of constipation symptom relief and the time of signs relief of the observation group were shorter , as compared with those of the control group, and there was significant difference, when comparisons were made between the 2 groups (P<0.05).The life function and overall quality of life scores and psychological state as well in the patients of the observation group were significantly su -perior to those of the control group , and significant differences could be noted , when comparisons were made between the 2 groups ( P<0.05).Conclusion Systemic nursing intervention on senile patients with multiple fracture of extremities could effectively increase the clinical efficacy and satisfaction of nursing on the part of family dependents , improve their life quality and psychological state of se-nile patients and relieve symptoms of constipation .With this reason , it was worth further clinical extension .