OBJECTIVE： To investigate the variety and frequency of oral tablets splitting commonly used in pediatrics of children’s hospital， and to explore the feasible scheme of tablet splitting， so as to provide the basis for clinical precision and individuation of drug use. METHODS： From 1st Jul. 2017 to 30th Nov. 2018， all the prescriptions of tablet varieties used for neonates hospitalized in internal and surgical departments in our hospital were obtained. The frequency of each tablet splitting was analyzed， and the literature reports of the tablets splitting were searched. The solubility， stability and recommended method of oral tablets splitting were analyzed， and the suggestion were made. RESULTS： In this study， there were 16 kinds of oral tablets that often needed to be divided into different doses， with a total frequency of 2 149 times. Vitamin B2， Levothyroxine sodium tablets and Ursodeoxycholic acid tablets ranked the top three in terms of dose splitting frequency， accounting for 80.3％ of the total dosing cases. After consulting the literature， the implementation process of the dosage division scheme was formulated， and the splitting methods of commonly used tablets were summarized. It is suggested that clinical evaluation of tablet and patient characteristics should be taken to determine tablet dosing splitting plan. CONCLUSIONS： Tablet dosing splitting is common in neonatal medication in our hospital. The methods of temporary dispensing tablet into oral liquid drugs summarized in this paper can provide references when necessary to meet the needs of clinical individualized drug use.