Objective To explore the correlation between plasma T cell subsets,serum interleukin-6(IL-6)levels and CT imaging characteristics in children with mycoplasma pneumoniae pneumonia(MPP),as well as its predictive value for clinical prognosis.Methods A total of 98 children with MPP were selected as the research subjects and divided into the good prognosis group(n=62)and the poor prognosis group(n=36)according to the clinical prognosis.The correlations between plasma T cell subsets,IL-6 levels,CT imaging characteristics and prognosis were analyzed.The predictive efficacy of plasma T cell subsets and IL-6 levels for poor progno-sis was analyzed.Results The levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),IL-6,CD8+and CD19+in the poor prognosis group were significantly higher than those in the good prognosis group,while the levels of CD3+,CD4+,CD4+/CD8+and CD16+/CD56+were significantly lower than those in the good prognosis group(P＜0.05).The statistical conditions of CT ima-ging characteristics such as pulmonary consolidation,ground-glass change,involvement of lung lobes ≥ 2,patchy consolidation shad-ows,grid nodular shadows,bronchial wall thickening,hilar lymph node enlargement,pleural effusion,and atelectasis in the poor prognosis group were significantly higher than those in the good prognosis group(P＜0.05).CD3+,CD4+,CD8+,CD4+/CD8+,CD19+,CD16+/CD56+and IL-6 had independent correlations with the above CT imaging characteristics.IL-6,CD8+and CD19+were positively correlated with the risk of poor prognosis,while CD3+,CD4+,CD4+/CD8+and CD16+/CD56+were negatively correlated with the risk of poor prognosis(P＜0.05).Individual detection of CD3+,CD4+,CD8+,CD4+/CD8+,CD19+,CD16+/CD56+,IL-6 and the combined detection of the seven indicators had certain predictive value for the occurrence of poor prognosis in patients[area under the curve(AUC)＞0.7].Conclusion Plasma T cell subsets and serum IL-6 levels are important factors influencing the prognosis of children with MPP and are independently related to the CT imaging characteristics.

Objective To explore the correlation between plasma T cell subsets,serum interleukin-6(IL-6)levels and CT imaging characteristics in children with mycoplasma pneumoniae pneumonia(MPP),as well as its predictive value for clinical prognosis.Methods A total of 98 children with MPP were selected as the research subjects and divided into the good prognosis group(n=62)and the poor prognosis group(n=36)according to the clinical prognosis.The correlations between plasma T cell subsets,IL-6 levels,CT imaging characteristics and prognosis were analyzed.The predictive efficacy of plasma T cell subsets and IL-6 levels for poor progno-sis was analyzed.Results The levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),IL-6,CD8+and CD19+in the poor prognosis group were significantly higher than those in the good prognosis group,while the levels of CD3+,CD4+,CD4+/CD8+and CD16+/CD56+were significantly lower than those in the good prognosis group(P＜0.05).The statistical conditions of CT ima-ging characteristics such as pulmonary consolidation,ground-glass change,involvement of lung lobes ≥ 2,patchy consolidation shad-ows,grid nodular shadows,bronchial wall thickening,hilar lymph node enlargement,pleural effusion,and atelectasis in the poor prognosis group were significantly higher than those in the good prognosis group(P＜0.05).CD3+,CD4+,CD8+,CD4+/CD8+,CD19+,CD16+/CD56+and IL-6 had independent correlations with the above CT imaging characteristics.IL-6,CD8+and CD19+were positively correlated with the risk of poor prognosis,while CD3+,CD4+,CD4+/CD8+and CD16+/CD56+were negatively correlated with the risk of poor prognosis(P＜0.05).Individual detection of CD3+,CD4+,CD8+,CD4+/CD8+,CD19+,CD16+/CD56+,IL-6 and the combined detection of the seven indicators had certain predictive value for the occurrence of poor prognosis in patients[area under the curve(AUC)＞0.7].Conclusion Plasma T cell subsets and serum IL-6 levels are important factors influencing the prognosis of children with MPP and are independently related to the CT imaging characteristics.

Purpose:To study the expression and functional way of EGF and bFGF in human prostatic tissue.Method:To detect the expression of EGF and bFGF in 6 cases of human normal prostate (NP) and 27 cases of benign prostatic hyperplasia (BPH) specimens using mRNA dot blot, in situ hybridization and immunohistochemistry.Results:There was no expression of EGF mRNA in any of the prostate exmined,weakly immunohistochemical staining of EGF was observed in 2 cases of 6 NP and 5 of 27 BPH sepcimens,there was no statistic difference between NP and BPH (P＞0.05).The total amount of bFGF mRNA in BPH tissue is much than that in NP tissue,aboundant bFGF mRNA was revealed in epithelial cells of 6 cases of NP tissues,but no bFGF;low amount of bFGF was expressed,according with the level of its mRNA both in basal and stromal cells of NP tissues;No signal for bFGF mRNA was found in epithelial cells of BPH tissues but bFGF protein was found on surface of local proliferating epithelial cells.Markedly increased expression of bFGF mRNA and its protein were present in basal and stromal cells of BPH tissues,especially in the region of local proliferating stromal cells.Conclusion:There are no EGF secretory cells in human normal or hyperplastic prostate; overexpression of bFGF in basal and stromal cells of human prostate caused irregular hyperplasia both of stromal elements and glandular epithelium via autocrine and paracrine pathways.