Objective:To analyze the factors influencing prognosis of intrahepatic cholangiocarcinoma (ICC) after surgical resection.Methods:The clinical data of patients diagnosed with ICC and who underwent surgical resection from December 2015 to December 2019 at the Fifth Medical Center of PLA General Hospital were retrospectively analyzed. Of 39 patients who were included in this study, there were 23 males and 16 females, with age of (54.1±7.2) years old. The body mass index, hepatitis B virus infection status, tumor diameter, degree of differentiation, microvascular tumor thrombus, lymph node metastasis, and serum levels of carbohydrate antigen 19-9 (CA19-9) were analyzed as risk factors affecting postoperative recurrence and survival.Results:The median times to recurrence were significantly better in patients with a tumour length <5 cm (11 vs. 5 months), patients without microvascular tumor thrombus (54 vs. 6 months) and patients without lymph node metastasis (8 vs. 5 months) (all P<0.05). The median survival of patients with CA19-9≥100 U/ml was significantly shorter than that of patients with CA19-9<100 U/ml, (9 vs. 27 months, P<0.05). Tumor diameter>5 cm, microvascular tumor thrombus, lymph node metastasis, and CA19-9 ≥100 U/ml are risk factors affecting the recurrence time after ICC resection, CA19-9 ≥100 U/ml is a risk factor affecting survival time after ICC resection. Conclusion:Tumor diameter, microvascular tumor thrombus, lymph node metastasis and CA19-9 can be used to estimate the risk of ICC recurrence, and CA19-9 level can be used to estimate postoperative survival of ICC patients after resection.

OBJECTIVE: To analyze the clinical characteristics and diagnosis of silicosis with pulmonary tuberculosis and pulmonary aspergillosis. METHODS: The clinical data of a case of silicosis combined with pulmonary tuberculosis and aspergillosis was analyzed retrospectively. RESULTS: The clinical symptoms of this patient were chest tightness, suffocation, cough, expectoration and hemoptysis. The patient was diagnosed as tuberculosis in the local hospital in 2015. Two previous sputum smears of the patient were positive for mycobacterium tuberculosis. Both qualitative analysis of blood tubercle bacilli and sputum smear examination of acid-fast bacilli were negative. Chest computed tomography(CT) showed right lung pneumoconiosis with large shadow, left lower lobe of lung with uneven density and flake shadow, low density necrotic foci, a cavity with smooth wall. Sputum fungal culture: Aspergillus fumigatus(+++); bronchoscopic lung biopsy showed: Aspergillus pneumoniae. CONCLUSION: Low immunity, malnutrition and long-term use of antibiotics and hormones are the high risk factors of pulmonary aspergillosis. It is helpful to combine laboratory examination, patients′ clinical manifestations and chest CT characteristics, and to analyze the condition comprehensively for the early diagnosis of silicosis with pulmonary aspergillosis.

Objective To explore Klotho protein in the pathogenesis of mild cognitive impairment (MCI) in Uygur and Han nationalities in Xinjiang.Methods The stratified,random and multistage cluster sampling way was used in MCI epidemiological survey of the elderly residents aged 60 years or over in Xinjiang area,and 161 ones with MCI (Uygur nationality 90 cases,Han nationality 71 cases) and 161 healthy people matched with ethnic,gender and blood pressure were selected (Uygur nationality 88 people,Han nationality 73 people).ELISA was used to detect Klotho protein concentrations in serum.Results The concentration of Klotho protein in MCI group (2 480.12 ± 1 379.05) ng/L was lower than in control group (3 070.34 ± 1 390.53) ng/L (P ＜ 0.05).The concentration of Klotho protein in Han MCI persons (2 810.35 ± 1 417.74) ng/L was lower than Han control group(3 341.87 ± 1 375.47) ng/L(P ＜0.05).The concentration of Klotho protein in Uygur MCI persons (2 215.37 ± 1 297.67) ng/L was lower than Uygur control group(2 840.36 ± 1 361.65) ng/L(P ＜0.05).The concentration of Klotho protein in Uygur MCI group was lower than Han MCI group (P ＜ 0.05).At the same time,the concentration of Klotho protein of Uygur control group was lower than Han control group (P ＜ 0.05).The concentrations of Klotho protein was related to MMSE score(rs =0.209,P＜0.05) and age(rs =-0.240,P＜0.05).Conclusions The concentration of Klotho protein may be related to the pathogenesis of MCI.

Objective To explore Klotho protein in the pathogenesis of mild cognitive impairment (MCI) in Uygur and Han nationalities in Xinjiang.Methods The stratified,random and multistage cluster sampling way was used in MCI epidemiological survey of the elderly residents aged 60 years or over in Xinjiang area,and 161 ones with MCI (Uygur nationality 90 cases,Han nationality 71 cases) and 161 healthy people matched with ethnic,gender and blood pressure were selected (Uygur nationality 88 people,Han nationality 73 people).ELISA was used to detect Klotho protein concentrations in serum.Results The concentration of Klotho protein in MCI group (2 480.12 ± 1 379.05) ng/L was lower than in control group (3 070.34 ± 1 390.53) ng/L (P ＜ 0.05).The concentration of Klotho protein in Han MCI persons (2 810.35 ± 1 417.74) ng/L was lower than Han control group(3 341.87 ± 1 375.47) ng/L(P ＜0.05).The concentration of Klotho protein in Uygur MCI persons (2 215.37 ± 1 297.67) ng/L was lower than Uygur control group(2 840.36 ± 1 361.65) ng/L(P ＜0.05).The concentration of Klotho protein in Uygur MCI group was lower than Han MCI group (P ＜ 0.05).At the same time,the concentration of Klotho protein of Uygur control group was lower than Han control group (P ＜ 0.05).The concentrations of Klotho protein was related to MMSE score(rs =0.209,P＜0.05) and age(rs =-0.240,P＜0.05).Conclusions The concentration of Klotho protein may be related to the pathogenesis of MCI.

OBJECTIVE:To study the pharmacodynamics of Xiaozhongzhitong capsules.METHODS:The pharmacodynamics of Xiaozhongzhitong capsules was studied through rat mesenteric microcirculation test,mouse pain writhing test and mouse ear swelling test.RESULTS:The Xiaozhongzhitong capsules improved rats' mesenteric microcirculation disturbance, attenuated the pain action of mouse induced by acetate acid,and significantly inhabited the ear swelling of mouse caused by dimethylbenzene.CONCLUSION:Xiaozhongzhitong capsules showed proved efficacy in activating blood,dissolving stasis, eliminating swelling and alleviating pain,and the results serve as an experimental basis for the clinical application of Xiao zhongzhitong capsules.