1.Hepatic lesion caused by oxycodone-acetaminophen tablet in two patients
Yang SHI ; Lishan XU ; Zhaogang ZENG ; Wei ZHANG ; Haixia ZHOU ; Dengfeng FAN
Adverse Drug Reactions Journal 2017;19(5):395-396
Two female patients(patient 1:41 years old,patient 2:61 years old)received oxycodone-acetaminophen tablets orally at a dose of 330 mg every 6 hours daily for postoperative analgesia. Their hepatic functions were normal before the drug administration. Their liver enzymes levels were increased 2 days and 1 day after drug administration(case 1:ALT 471 U/L,AST 710 U/L,ALP 114 U/L,γ-GT 222 U/L,case 2:ALT 154 U/L,AST 96 U/L,ALP 164 U/L,γ-GT 210 U/L). In addition,case 1 developed the symptoms of dizziness,headache,nausea and vomiting. The two patients stopped the drug on day 2 and 4 after the appearance of hepatic lesion,respectively. They received liver protection therapy which included IV infusion of vitamin C and vitamin B6,polyene phosphatidyl choline capsules,glucuronolactone tablets and silibinin capsules by oral administration. The results of reexamination 20 days after drug withdrawal in patient 1 showed ALT 14 U/L,AST 17 U/L,ALP 32 U/L,and γ-GT 30 U/L. The results of reexamination 21 days after drug withdrawal in patient 2 showed ALT 23 U/L,AST 26 U/L,ALP 87 U/L,and γ-GT 55 U/L.
2.Hepatic lesion caused by oxycodone-acetaminophen tablet in two patients
Yang SHI ; Lishan XU ; Zhaogang ZENG ; Wei ZHANG ; Haixia ZHOU ; Dengfeng FAN
Adverse Drug Reactions Journal 2017;19(5):395-396
Two female patients(patient 1:41 years old,patient 2:61 years old)received oxycodone-acetaminophen tablets orally at a dose of 330 mg every 6 hours daily for postoperative analgesia. Their hepatic functions were normal before the drug administration. Their liver enzymes levels were increased 2 days and 1 day after drug administration(case 1:ALT 471 U/L,AST 710 U/L,ALP 114 U/L,γ-GT 222 U/L,case 2:ALT 154 U/L,AST 96 U/L,ALP 164 U/L,γ-GT 210 U/L). In addition,case 1 developed the symptoms of dizziness,headache,nausea and vomiting. The two patients stopped the drug on day 2 and 4 after the appearance of hepatic lesion,respectively. They received liver protection therapy which included IV infusion of vitamin C and vitamin B6,polyene phosphatidyl choline capsules,glucuronolactone tablets and silibinin capsules by oral administration. The results of reexamination 20 days after drug withdrawal in patient 1 showed ALT 14 U/L,AST 17 U/L,ALP 32 U/L,and γ-GT 30 U/L. The results of reexamination 21 days after drug withdrawal in patient 2 showed ALT 23 U/L,AST 26 U/L,ALP 87 U/L,and γ-GT 55 U/L.
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