Objective:To explore the impact of female body mass index (BMI) on clinical outcomes in patients treated with intrauterine insemination (IUI).Methods:This study was a retrospective cohort study. A total of 21 137 patients who visited the Reproductive Medical Center, the First Affiliated Hospital of Zhengzhou University from January 2010 to December 2021 were recruited. The patients underwent the first IUI cycles, including artificial insemination by husband (AIH) and artificial insemination by donor (AID). According to clinical pregnancy or not, it is divided into pregnancy group and non-pregnancy group. The basic parameters between clinical pregnancy group and non-clinical pregnancy group were compared. According to the BMI, patients were divided into 4 groups, group A: BMI≤18.5 kg/m 2, group B: 18.6-23.9 kg/m 2, group C: 24.0-27.9 kg/m 2and group D: BMI≥28.0 kg/m 2. Patients' basic parameters and clinical outcomes were compared among the four groups. Multivariate logistic regression analysis was used to explore the impact of BMI on pregnancy outcomes. Results:In all IUI cycles, BMI was significantly different between pregnant patients and non-pregnant patients [(24.58±3.52) kg/m 2vs. (23.35±4.20) kg/m 2, P<0.001]. In AIH cycles, clinical pregnancy rate [18.21% (877/4 815), 17.12% (222/1 297)] and early spontaneous miscarriage rate [17.10% (150/877), 21.62% (48/222)] were significantly higher in patients of group C and group D than in group A [11.24% (130/1 157), 10.77% (14/130)] and group B [13.40% (1 229/9 174), 15.30% (188/1 229)]. The differences among the 4 groups were statistically significant ( P=0.012, P=0.003). However, BMI was not associated with clinical pregnancy rate in multivariate logistic analysis, but obesity was a predictor for early spontaneous miscarriage ( OR=1.63, 95% CI: 1.25-1.95, P=0.003). In AID cycles, pregnancy outcomes were comparable among the four BMI groups. Obesity significantly increased early spontaneous miscarriage rate ( OR=1.58, 95% CI: 1.14-1.87, P=0.016). Conclusion:Female BMI is not associated with clinical outcomes in IUI cycles. Obesity is a predictor for early spontaneous miscarriage in both AIH and AID cycles.

Objective:To explore the impact of female body mass index (BMI) on clinical outcomes in patients treated with intrauterine insemination (IUI).Methods:This study was a retrospective cohort study. A total of 21 137 patients who visited the Reproductive Medical Center, the First Affiliated Hospital of Zhengzhou University from January 2010 to December 2021 were recruited. The patients underwent the first IUI cycles, including artificial insemination by husband (AIH) and artificial insemination by donor (AID). According to clinical pregnancy or not, it is divided into pregnancy group and non-pregnancy group. The basic parameters between clinical pregnancy group and non-clinical pregnancy group were compared. According to the BMI, patients were divided into 4 groups, group A: BMI≤18.5 kg/m 2, group B: 18.6-23.9 kg/m 2, group C: 24.0-27.9 kg/m 2and group D: BMI≥28.0 kg/m 2. Patients' basic parameters and clinical outcomes were compared among the four groups. Multivariate logistic regression analysis was used to explore the impact of BMI on pregnancy outcomes. Results:In all IUI cycles, BMI was significantly different between pregnant patients and non-pregnant patients [(24.58±3.52) kg/m 2vs. (23.35±4.20) kg/m 2, P<0.001]. In AIH cycles, clinical pregnancy rate [18.21% (877/4 815), 17.12% (222/1 297)] and early spontaneous miscarriage rate [17.10% (150/877), 21.62% (48/222)] were significantly higher in patients of group C and group D than in group A [11.24% (130/1 157), 10.77% (14/130)] and group B [13.40% (1 229/9 174), 15.30% (188/1 229)]. The differences among the 4 groups were statistically significant ( P=0.012, P=0.003). However, BMI was not associated with clinical pregnancy rate in multivariate logistic analysis, but obesity was a predictor for early spontaneous miscarriage ( OR=1.63, 95% CI: 1.25-1.95, P=0.003). In AID cycles, pregnancy outcomes were comparable among the four BMI groups. Obesity significantly increased early spontaneous miscarriage rate ( OR=1.58, 95% CI: 1.14-1.87, P=0.016). Conclusion:Female BMI is not associated with clinical outcomes in IUI cycles. Obesity is a predictor for early spontaneous miscarriage in both AIH and AID cycles.

Objective To evaluate the clinical efficacy and safety of nanoparticle albumin-bound paclitaxel (Nab-P) in the treatment of advanced non-small cell lung cancer (NSCLC). Methods Fifty-six over 65 years old patients with advanced NSCLC treated with Nab-P monotherapy in department of chemotherapy of the People's Hospital of Zhongshan City from January 2014 to January 2017 were analyzed retrospectively. The chemotherapy regimen was Nab-P 260 mg/m2, on d1 or d1 + d8, every 21 day for a cycle, imaging examination was made for efficacy evaluation after every 2 cycles. Results All 56 patients had been evaluated for efficacy, and received a total of 186 cycles of chemotherapy. All patients had been completed 2 cycles or more than 2 cycles of chemotherapy, and the median number of chemotherapy cycles was 3. The treatment response rate (RR) was 25.0 ％ and the disease control rate (DCR) was 76.8 ％. The median progression free survival (PFS) time was 4.7 months. The main adverse reactions were neutropenia, nausea and vomiting, fatigue and peripheral nerve toxicity. However, the vast majorities of adverse reactions were grade 1-2, and can be improved after treatment. Conclusions Nab-P is effective in the treatment of advanced NSCLC in elderly patients. The adverse reactions are mild and tolerant, and it is worthy to be popularized.

ObjectiveTo evaluate the short-term effect and side effects of ICE regimen treating the patients with relapsed and refractory non-Hodgkin's lymphoma(NHL). MethodsTwenty-five patients with relapsed and refractory NHL were treated with ICE regimen. Treatment was repeated every 3 weeks. ResultsThe total effective rate was 76.0％ for 25 patients,The response rate(PR) was 60.0％. The main side effects were marrow suppression including of leucopenia and thrombocytopenia,no patients dead for toxic reactions of chemotherapy. ConclusionICE regimen was a safe and effective salvage regimen for the patients with relapsed and refractory NHL.

Objective To probe into the current services and outcomes of township hospitals following their transformation, and their future positioning of functionality. Methods Pinpointing townships A, B and C as samples from a district in Beijing, in which field surveys were made in the township hospitals to learn their services, service provision methods and outcomes. Results Among the current services provided by these three hospitals, those of public health and primary healthcare nature in hospital A account for 50% each; those in hospital B account for 70% and 30% respectively; those in hospital C account for 60% and 40% respectively. Recommendable services provided in these hospitals include universal coverage of medical files, management of infectious diseases, public health emergency management, and immunization. Conclusion Township hospitals as the center of the 3-tier rural health service network, deserve a repositioning of their functionality to fit the health needs of residents at large.

BACKGROUND: There is no accepted treatment for liver fibrosis recently. Bone marrow meaenchymal stern cells (BMSCs) used in the treatment of liver fibrosis has been reported as an effectively treatment, but the mechanism is unclear.OBJECTIVE: To study the regulation of hepatic stellate cells mediated by human BMSCs in vitro.DESIGN, TIME AND SETTING: The cytological in vitro study was performed at the Center for Stem Cells and Tissue Engineering of Sun Yat-sen University and the Central Laboratory of Third Affiliated Hospital of Sun Yat-sen University from June to December 2008.MATERIALS: Human bone marrow masenchymal stem cells were collected from normal youth volunteers; Human hepatic stellate cells and normal liver call line L-O2 were supplied by the Animal Experimental Center of Sun Yat-sen University.METHODS: The purified human BMSCs and hepatic stellate calls were set up in Transwell co-culture system. The incubation density was 2×104cells/well. L-O2 was set up instead of human BMSCs as negative control. Hepatic stellate cells cultured alone served as blank control group. The culture was performed for 72 hours.MAIN OUTCOME MEASURES: Morphology of hepatic stellate cells and results of immunocytochemical staining. Apoptosis of hepatic stellte calls was determined by flow cytometry. Western blot were used to assay the expression of α-actin.RESULTS: Activated hepatic stellate cells presented fiat and thin shape under an inverted microscope. Fat drop was lack in cytoplasm, a -actin located in hepatic stellate calls, with the presence of high tension fibers. Compared with the L-O2 + hepatic stellate cell and hepatic stellate call groups, the apoptotic rate of hepatic stellate cells was significantly increased in the BMSC + hepatic stellate cell group (P < 0.05). α -actin expression was significantly down-regulated.CONCLUSION: Human BMSCs can inhibit activation of hepatic stellate ceils and promote them apoptosis, which may be the anti-hepatic fibrosis mechanism of BMSCs.

Objective To construct the bioartificial liver by bone mesenchymal stem cell (BMSC) and alginate scaffold. Method Alginate scaffold was used as the cell carrier for the cultivation of BMSC and the differentiation from BMSC into hepatic like cells was induced by the cell factors of HGF, EGF and FGF-4 in the scaffold in vitro. The compatibility of the cells and the scaffold was observed by microscopy and the function of the differentiatd cells was tested. The gene of AFP and ALB was detected by RT-PCR. The secretion of ALB and the urea synthesis of the cells were tested by ALB kit and urea kit respectively. The glycogen synthesis and the CK-18 was tested by the glycogen stanning method and the immunofluorescence test. Results BMSC was able to attach, grow and proliferate well in the alginate scaffold, the well compatibility was observed by microscopy. ALB and urea were detected in the cultivating medium, the gene of ALB and AFP was identified by RT-PCR. The glycogen synthesis ability and the expression of CK-18 were induced during the differentiation. Conclusion The three dimensional atginate scaffold exhibited well compatibility with BMSC, BMSC could be differentiated into the hepatic like cell in the scaffold. BMSC and the alginate scaffold could be used to construct the bioartificial liver for the hepatic tissue engineering.

0.05).Conclusion There is no significant difference of short-term effect between the two groups in treating advanced NSCLC,and the method has mild digestive reactions and nephrotoxicity.