To report a case of onychocytic carcinoma in China. A 76-year-old female patient presented with a subnail mass on her left thumb for 3 years. Skin examination showed thickening of the left thumb plate whose surface was partially yellow and black in color, slight curving of the distal plate, obvious telangiectasia under the nail plate, and verrucous hyperplasia under the nail plate and at the lateral edge of the nail plate. Histopathological examination showed that the tumor grew and infiltrated downward in clumps, with obvious keratosis and necrosis in the center of the mass, and many "squamous vortex" structures, atypical cells, and pathological mitotic figures could be seen. Immunohistochemical study revealed that HK31 and HK85 were positively expressed in the squamous vortex region, K6/K16 was positively expressed in the basal part of the tumor, and HK75 was strongly expressed in the whole tumor region. The diagnosis of onychocytic carcinoma was confirmed. The patient received surgical excision combined with 3 sessions of photodynamic therapy, and no recurrence was observed during 18 months of follow-up.

Objective:To explore a method to shorten the time for preparation and delivery of cytotoxic antineoplastic drugs in pharmacy intravenous admixture services (PIVAS), so that patients can use drugs in time according to the drug labels.Methods:The circumstances of prolonged preparation and delivery time of cytotoxic antineoplastic drugs prepared in PIVAS in Beijing Tiantan Hospital from October 8 to December 31, 2018 were investigated by the project team, the causes were analyzed, and the improvement strategies were made. The drug preparation and delivery time after the improvement strategies was counted and compared with that before improvement to evaluate the improvement effect.Results:From 8 October to 31 December 2018, a total of 4 156 bags of cytotoxic antineoplastic drugs were prepared and delivered in PIVAS in our hospital and the delivery time of 951 bags need to be paid attention to. Though the recording time was not accurate, it could be determined that the delivery time of at least 4.7% (45/951) of those bags had been extended. After taking the improvement measures of priority review for prescription of cytotoxic antineoplastic drugs, priority preparation, and delivery by special person from 20 January 2020, the delivery time of drugs was shortened from 2.5-4.5 hours to 0.5-4.0 hours, and the incidence of delivery time prolongation decreased to 0.9% (12/1 281).Conclusions:In hospital PIVAS, there was a phenomenon of delivery time prolongation of cytotoxic antineoplastic drugs when the drugs were delivered, which might lead to the storage time of the liquid exceeding the requirements of the drug labels. Priority prescription review and delivery of cytotoxic antineoplastic drugs could effectively shorten the delivery time.

Objective:To explore a method to shorten the time for preparation and delivery of cytotoxic antineoplastic drugs in pharmacy intravenous admixture services (PIVAS), so that patients can use drugs in time according to the drug labels.Methods:The circumstances of prolonged preparation and delivery time of cytotoxic antineoplastic drugs prepared in PIVAS in Beijing Tiantan Hospital from October 8 to December 31, 2018 were investigated by the project team, the causes were analyzed, and the improvement strategies were made. The drug preparation and delivery time after the improvement strategies was counted and compared with that before improvement to evaluate the improvement effect.Results:From 8 October to 31 December 2018, a total of 4 156 bags of cytotoxic antineoplastic drugs were prepared and delivered in PIVAS in our hospital and the delivery time of 951 bags need to be paid attention to. Though the recording time was not accurate, it could be determined that the delivery time of at least 4.7% (45/951) of those bags had been extended. After taking the improvement measures of priority review for prescription of cytotoxic antineoplastic drugs, priority preparation, and delivery by special person from 20 January 2020, the delivery time of drugs was shortened from 2.5-4.5 hours to 0.5-4.0 hours, and the incidence of delivery time prolongation decreased to 0.9% (12/1 281).Conclusions:In hospital PIVAS, there was a phenomenon of delivery time prolongation of cytotoxic antineoplastic drugs when the drugs were delivered, which might lead to the storage time of the liquid exceeding the requirements of the drug labels. Priority prescription review and delivery of cytotoxic antineoplastic drugs could effectively shorten the delivery time.