Objectives:To analyze the correlation between the the body shape index(ABSI)and all-cause mortality(ACM)as well as cardiovascular mortality(CVM)in patients with acute heart failure.Methods:This study analyzed data from the National Registration Study of Major Chronic Diseases,a prospective cohort on heart failure.A total of 4 907 patients with acute heart failure were enrolled from multiple centers nationwide,of which 4 375 were eligible for this study.The relationships of between body mass index(BMI),waist circumference,and ABSI with ACM and CVM were assessed using multivariable cox proportional hazards models.Results:The mean age of the patients was(65.0±13.4)years,62.3%was male.The median follow-up time was 4.6(4.59,4.65)years,there were 1 972(45.1%)ACM and 1 400(32.0%)CVM.Multivariable cox regression analysis showed that higher ABSI was associated with an increased risk of mortality.Compared to the second quartile of ABSI,the hazard ratio(HR)for the highest(fourth)quartile were 1.29(95%CI:1.14-1.46,P<0.05)for ACM and 1.23(95%CI:1.06-1.43,P<0.05)for CVM.In contrast,BMI and waist circumference were inversely associated with risks of both ACM and CVM.Conclusions:ABSI can more intuitively reflect the correlation between obesity and death in patients with heart failure than BMI and waist circumference,which has important clinical significance.

Objectives:To analyze the correlation between the the body shape index(ABSI)and all-cause mortality(ACM)as well as cardiovascular mortality(CVM)in patients with acute heart failure.Methods:This study analyzed data from the National Registration Study of Major Chronic Diseases,a prospective cohort on heart failure.A total of 4 907 patients with acute heart failure were enrolled from multiple centers nationwide,of which 4 375 were eligible for this study.The relationships of between body mass index(BMI),waist circumference,and ABSI with ACM and CVM were assessed using multivariable cox proportional hazards models.Results:The mean age of the patients was(65.0±13.4)years,62.3%was male.The median follow-up time was 4.6(4.59,4.65)years,there were 1 972(45.1%)ACM and 1 400(32.0%)CVM.Multivariable cox regression analysis showed that higher ABSI was associated with an increased risk of mortality.Compared to the second quartile of ABSI,the hazard ratio(HR)for the highest(fourth)quartile were 1.29(95%CI:1.14-1.46,P<0.05)for ACM and 1.23(95%CI:1.06-1.43,P<0.05)for CVM.In contrast,BMI and waist circumference were inversely associated with risks of both ACM and CVM.Conclusions:ABSI can more intuitively reflect the correlation between obesity and death in patients with heart failure than BMI and waist circumference,which has important clinical significance.

AIM: To find the evidence of electrophysi ol ogic mechanisms associated with average spectrum of electrophysiological cochleo neural activity (ASECA), a measure of spontaneous auditory nerve activity altera tions. METHODS: The long-term salicylate treatment was used to establis h the available animal model of tinnitus, the ASECA was monitored, and the effec ts of various presented ipsilateral acoustic were investigated. RESULTS: (1) In the first treatment, ASECA decreased acutely dur ing several hours after salicylate administration. After several days (1 week an d 2 weeks) this decrease was reduced. (2) Over weeks of salicylate administratio n, the level of ASECA increased progressively, but at the end of treatment, acou stic tuning of ASECA showed a partially decreased sensitivity. (3) In control an imals, delivery of an ipsilateral noise reproduced the increase in the level of ASECA that was similar to the result observed in long-term salicylate-treated an imals. The noise (the white noise was 55-60 dB SPL) was of moderate level and it slightly elevated CAP thresholds at higher frequencies. CONCLUSION: In the long-term salicylate-treated animals, the ASE CA-1 kHz increased reflects strongly increased synchronized activity in the audi tory nerve.