Objective To discuss the mediating role of psychological consistency in self-perceived burden and quality of life in patients receiving 125I seed implantation treatment.Methods By using convenient sampling method a questionnaire was conducted in 154 patients,who received 125I seed implantation in Zhejiang Provincial Cancer Hospital between September 2021 and April 2022,were selected as the study subjects,and SPSS 23.0 and AMOS 24.0 were used for data analysis.Results Psychological consistency was negatively correlated with self-perceived burden(r=-0.353,P＜0.01)and was positively correlated with quality of life(r=0.457,P＜0.01).Self-perceived burden was negatively correlated with quality of life(r=-0.604,P＜0.01).Structural equation testing proved that psychological consistency had certain partial mediating effect on self-perceived burden and quality of life,accounting for 20.7％of the total effect.Conclusion Psychological consistency can not only directly affect the quality of life of patients,but also indirectly affect the quality of life of patients as a mediating variable of self-perceived burden.