1.Observation on brain development of 0-6 years healthy children based on structural MRI
Wei YU ; Feng YANG ; Kang YANG ; Zhangzhi FENG ; Ming YANG
Chinese Journal of Medical Imaging Technology 2025;41(2):234-238
Objective To observe brain development of 0-6 years healthy children based on 3D-structural MRI(sMRI).Methods Brain 3D-sMRI T1WI of 228 healthy children aged 0-6 years were retrospectively analyzed.The absolute volume of total brain volume(TBV),white matter volume(WMV),total gray matter volume(tGMV),cortical gray matter volume(GMV)and subcortical gray matter volume(sGMV),as well as standardized values of the above indexes except for TBV were obtained,and the cortical surface area and thickness were measured.The changes of above parameters in different ages were analyzed.Results During 0-5 years,TBV and the absolute volume of WMV,tGMV,GMV and sGMV increased(all P＜0.05)with gradually slowed down speed,while during 5-6 years,no significant increase of the above parameters was noticed(all P＞0.05).During 0-1 year,standardized WMV and sGMV decreased,then the former gradually increased during 1-4 years(all P＜0.05),while the latter did not change significantly(all P＞0.05),and no significant change of standardized WMV nor sGMV were found during 4-6 years(all P＞0.05).During 0-1 year,both standardized tGMV and GMV increased,while during 1-6 years,except for significant decrease in standardized tGMV during 3-4 years(P＜0.05),other parameters remained relatively stable(all P＞0.05).Cerebral cortex surface area increased during 0-5 years(all P＜0.05),especially during 0-3 years,which did not obviously enlarge during 5-6 years old(P＞0.05).Cerebral cortex thickness increased rapidly during 0-1 year and reached peak at about 1.5 years,then presented slow fluctuations without significant changes(all P＞0.05).Conclusion Brain development of 0-6 years healthy children had certain characteristics.
2.Observation on brain development of 0-6 years healthy children based on structural MRI
Wei YU ; Feng YANG ; Kang YANG ; Zhangzhi FENG ; Ming YANG
Chinese Journal of Medical Imaging Technology 2025;41(2):234-238
Objective To observe brain development of 0-6 years healthy children based on 3D-structural MRI(sMRI).Methods Brain 3D-sMRI T1WI of 228 healthy children aged 0-6 years were retrospectively analyzed.The absolute volume of total brain volume(TBV),white matter volume(WMV),total gray matter volume(tGMV),cortical gray matter volume(GMV)and subcortical gray matter volume(sGMV),as well as standardized values of the above indexes except for TBV were obtained,and the cortical surface area and thickness were measured.The changes of above parameters in different ages were analyzed.Results During 0-5 years,TBV and the absolute volume of WMV,tGMV,GMV and sGMV increased(all P＜0.05)with gradually slowed down speed,while during 5-6 years,no significant increase of the above parameters was noticed(all P＞0.05).During 0-1 year,standardized WMV and sGMV decreased,then the former gradually increased during 1-4 years(all P＜0.05),while the latter did not change significantly(all P＞0.05),and no significant change of standardized WMV nor sGMV were found during 4-6 years(all P＞0.05).During 0-1 year,both standardized tGMV and GMV increased,while during 1-6 years,except for significant decrease in standardized tGMV during 3-4 years(P＜0.05),other parameters remained relatively stable(all P＞0.05).Cerebral cortex surface area increased during 0-5 years(all P＜0.05),especially during 0-3 years,which did not obviously enlarge during 5-6 years old(P＞0.05).Cerebral cortex thickness increased rapidly during 0-1 year and reached peak at about 1.5 years,then presented slow fluctuations without significant changes(all P＞0.05).Conclusion Brain development of 0-6 years healthy children had certain characteristics.
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