BACKGROUND:Collagen is the main component of extracellular matrix.With its stable triple helix structure,good biological characteristics and machinability,collagen is an ideal biomedical material and has been widely used in the field of medical devices.OBJECTIVE:To analyze the main product morphology,technical characteristics,preparation process,and clinical application of solid collagen-based materials.METHODS:The research on solid collagen-based materials in the field of medical devices included in PubMed and CNKI was searched by computer.The English and Chinese search terms were"collagen,collagen sponge,collagen membrane,collagen powder,collagen gel,decellularized extracellular martix,medical device,clinical application."After preliminary screening of all articles according to inclusion and exclusion criteria,92 articles with higher quality and relevance were retained for review.RESULTS AND CONCLUSION:Solid collagen-based materials from animal sources have been used as materials for the preparation of medical devices,and remarkable progress has been made in raw material extraction,preparation technology,and clinical application.Marine biological collagen and recombinant collagen have increased the selectivity of collagen sources.There are various types of solid collagen-based medical devices and various preparation methods,among which crosslinking modification is an important way to improve material properties,which is worthy of further study.In terms of product development ideas,research on solid collagen-based medical device products is developing in the direction of trivialization and biochemistry,and the research on compounding with other biological materials and drugs has also shown great potential.Although many collagen-based medical devices have been used clinically in China,product development in the fields of artificial skin,cartilage repair,and nerve injury repair is still insufficient,and further breakthroughs and innovations in technology and industrialization are needed.

Liposuction abdominoplasty is a prevalent procedure in plastic surgery, with common complications including infection and bleeding. However, cases leading to intestinal rupture accompanied by extensive abdominal wall infection are extremely infrequent. One such case was reported in this article. The patient was a 37-year-old female who developed symptoms of abdominal pain, vomiting, and fever after undergoing liposuction abdominoplasty at another hospital. She was admitted to the First Affiliated Hospital of Wenzhou Medical University on October 27, 2023. CT scan revealed a right lower abdominal wall hernia, intestinal obstruction, and abdominal wall infection. Intra-operative exploration demonstrated that a portion of the ileum had herniated subcutaneously, with multiple small perforations. There was also widespread soft-tissue infection in the subcutaneous area, along with partial skin necrosis. Emergency surgery was performed to repair the ruptured intestine. Biological dressing were used to cover and protect the exposed intestinal wall and the defective abdominal wall. Multiple debridement procedures and vacuum sealing drainage were performed for the extensive subcutaneous soft-tissue infection. Bacterial culture of the drainage fluid indicated Escherichia coli infection, and imipenem-cilastatin was administered for anti-infective treatment. After the infection was controlled, the wound was repaired with local flaps and fascia lata. During the six-month follow-up after discharge, the patient’s general condition remained satisfactory, with normal dietary intake and a well-healed wound. This case report particularly highlights that for patients with a prior history of abdominal surgery should undergo preoperative abdominal CT and other relevant examinations before liposuction to exclude potential risk factors such as incisional hernias and ensure patient safety.

Liposuction abdominoplasty is a prevalent procedure in plastic surgery, with common complications including infection and bleeding. However, cases leading to intestinal rupture accompanied by extensive abdominal wall infection are extremely infrequent. One such case was reported in this article. The patient was a 37-year-old female who developed symptoms of abdominal pain, vomiting, and fever after undergoing liposuction abdominoplasty at another hospital. She was admitted to the First Affiliated Hospital of Wenzhou Medical University on October 27, 2023. CT scan revealed a right lower abdominal wall hernia, intestinal obstruction, and abdominal wall infection. Intra-operative exploration demonstrated that a portion of the ileum had herniated subcutaneously, with multiple small perforations. There was also widespread soft-tissue infection in the subcutaneous area, along with partial skin necrosis. Emergency surgery was performed to repair the ruptured intestine. Biological dressing were used to cover and protect the exposed intestinal wall and the defective abdominal wall. Multiple debridement procedures and vacuum sealing drainage were performed for the extensive subcutaneous soft-tissue infection. Bacterial culture of the drainage fluid indicated Escherichia coli infection, and imipenem-cilastatin was administered for anti-infective treatment. After the infection was controlled, the wound was repaired with local flaps and fascia lata. During the six-month follow-up after discharge, the patient’s general condition remained satisfactory, with normal dietary intake and a well-healed wound. This case report particularly highlights that for patients with a prior history of abdominal surgery should undergo preoperative abdominal CT and other relevant examinations before liposuction to exclude potential risk factors such as incisional hernias and ensure patient safety.

BACKGROUND:Collagen is the main component of extracellular matrix.With its stable triple helix structure,good biological characteristics and machinability,collagen is an ideal biomedical material and has been widely used in the field of medical devices.OBJECTIVE:To analyze the main product morphology,technical characteristics,preparation process,and clinical application of solid collagen-based materials.METHODS:The research on solid collagen-based materials in the field of medical devices included in PubMed and CNKI was searched by computer.The English and Chinese search terms were"collagen,collagen sponge,collagen membrane,collagen powder,collagen gel,decellularized extracellular martix,medical device,clinical application."After preliminary screening of all articles according to inclusion and exclusion criteria,92 articles with higher quality and relevance were retained for review.RESULTS AND CONCLUSION:Solid collagen-based materials from animal sources have been used as materials for the preparation of medical devices,and remarkable progress has been made in raw material extraction,preparation technology,and clinical application.Marine biological collagen and recombinant collagen have increased the selectivity of collagen sources.There are various types of solid collagen-based medical devices and various preparation methods,among which crosslinking modification is an important way to improve material properties,which is worthy of further study.In terms of product development ideas,research on solid collagen-based medical device products is developing in the direction of trivialization and biochemistry,and the research on compounding with other biological materials and drugs has also shown great potential.Although many collagen-based medical devices have been used clinically in China,product development in the fields of artificial skin,cartilage repair,and nerve injury repair is still insufficient,and further breakthroughs and innovations in technology and industrialization are needed.

Objective To observe the influence of ultra-shortwave (USW) irradiation on infarct volume and Ca2+-ATPase (SPCA) secretion after brain ischemia and reperfusion.Methods Eighty Sprague-Dawley rats were randomly divided into a sham operation group (n=8),a model group (n=36) and a USW group (n=36).The animal model of middle cerebral artery ischemia and reperfusion (MCAO/R) was established using the suture method in the rats of the model and USW groups,while the sham operation group was given the same operation but without inserting the thread plug.One day,3 days and 7 days after the intervention,12 rats were sacrificed and the infarct volumes and SPCA1 protein expression were measured using 2,3,5-triphenyltetrazolium chloride staining and western blotting.Results No white infarcted tissue was found in the sham operation group.In the model and USW groups the volume of infarcted tissue decreased with time.Significantly less infarcted volume was observed in the USW group compared to the model group at each time point.The SPCA1 levels in the brain tissue were lower than in the sham operation group after one and 3 days of USW treatment,but they were significantly lower in the model group as well.As time went by,the average SPCA1 level increased significantly in the model and USW groups.A slightly higher SPCA1 level was observed in the USW group compared to the model group after one day of treatment,but with no significance.However,significant differences were found between them after 3 and 7 days of intervention.Conclusion Ultra-shortwave irradiation can protect against MCAO/R injury by decreasing the infarcted volume,which may be related to down-regulation of SPCA1,minimizing nerve cell apoptosis and promoting neural functional recovery,at least in rats.