Objective To analyze the cunent situation and latent profiles of nurses'perceived organizational support,and explore the influencing factors of different types.Methods Through convenience sampling,a total of 1,860 nurses from the Pearl River Delta,Northern Guangdong,Eastern Guangdong and Western Guangdong regions of Guangdong Province were selected for the survey between October and December 2023.The demographic questionnaire,the Perceived Organizational Support Scale,and the Psychological Resilience Scale were used for investigation.The latent profiles of the nurses'perceived organizational support,the influencing factors of latent profiles were identified by single-factor analysis and multivariate Logistic regression.Results The score of the items of the perceived organizational support in l,819 nurses is(3.47±0.88)scores.Nurses perceived organizational support is divided into 3 latent classes,namely"poor group"(10.1％),"balanced group"(44.4％),and"rich group"(45.5％).The influencing factors include recruitment type,hospital level,and psychological resilience(all P＜0.05).Conclusion The perceived organizational support among nurses is moderately high and heterogeneous,which could be divided into 3 latent profiles.Nursing managers should focus on nurses from the poor group and balanced group and intervene with nurses according to the influencing factors of the different latent profiles to improve the level of nurses perceived organizational support.

Objective To analyze the cunent situation and latent profiles of nurses'perceived organizational support,and explore the influencing factors of different types.Methods Through convenience sampling,a total of 1,860 nurses from the Pearl River Delta,Northern Guangdong,Eastern Guangdong and Western Guangdong regions of Guangdong Province were selected for the survey between October and December 2023.The demographic questionnaire,the Perceived Organizational Support Scale,and the Psychological Resilience Scale were used for investigation.The latent profiles of the nurses'perceived organizational support,the influencing factors of latent profiles were identified by single-factor analysis and multivariate Logistic regression.Results The score of the items of the perceived organizational support in l,819 nurses is(3.47±0.88)scores.Nurses perceived organizational support is divided into 3 latent classes,namely"poor group"(10.1％),"balanced group"(44.4％),and"rich group"(45.5％).The influencing factors include recruitment type,hospital level,and psychological resilience(all P＜0.05).Conclusion The perceived organizational support among nurses is moderately high and heterogeneous,which could be divided into 3 latent profiles.Nursing managers should focus on nurses from the poor group and balanced group and intervene with nurses according to the influencing factors of the different latent profiles to improve the level of nurses perceived organizational support.

Senescence of activated hepatic stellate cells (aHSCs) is a stable growth arrest that is implicated in liver fibrosis regression. Senescent cells often accompanied by a multi-faceted senescence-associated secretory phenotype (SASP). But little is known about how alanine-serine-cysteine transporter type-2 (ASCT2), a high affinity glutamine transporter, affects HSC senescence and SASP during liver fibrosis. Here, we identified ASCT2 is mainly elevated in aHSCs and positively correlated with liver fibrosis in human and mouse fibrotic livers. We first discovered ASCT2 inhibition induced HSCs to senescence in vitro and in vivo. The proinflammatory SASP were restricted by ASCT2 inhibition at senescence initiation to prevent paracrine migration. Mechanically, ASCT2 was a direct target of glutaminolysis-dependent proinflammatory SASP, interfering IL-1α/NF-κB feedback loop via interacting with precursor IL-1α at Lys82. From a translational perspective, atractylenolide III is identified as ASCT2 inhibitor through directly bound to Asn230 of ASCT2. The presence of -OH group in atractylenolide III is suggested to be favorable for the inhibition of ASCT2. Importantly, atractylenolide III could be utilized to treat liver fibrosis mice. Taken together, ASCT2 controlled HSC senescence while modifying the proinflammatory SASP. Targeting ASCT2 by atractylenolide III could be a therapeutic candidate for liver fibrosis.