A 44-year-old male patient received sodium valproate tablets 0.2 g and carbamazepine 0.1 g twice daily orally for a long time due to epilepsy, rabeprazole sodium enteric-coated tablets 10 mg once daily orally for a long time due to duodenal ulcer. Due to poor efficacy, the antiepileptic drug was adjusted to sodium valproate sustained-release tablets 0.5 g orally twice daily in combination with levetiracetam 0.25 g orally twice daily, and paroxetine 20 mg orally once daily because of depression was given at the same time. After about 3 months of treatments, the patient repeatedly suffered from limb convulsions, and the laboratory test showed serum sodium 128 mmol/L. Oral and intravenous sodium supplementation were given for 16 days, but his blood sodium level was still less than 130 mmol/L. It was considered that the hyponatremia of the patient might be caused by drugs. After stopping paroxetine, the patient′s blood sodium concentration returned to 140 mmol/L 2 days later.

A 44-year-old male patient received sodium valproate tablets 0.2 g and carbamazepine 0.1 g twice daily orally for a long time due to epilepsy, rabeprazole sodium enteric-coated tablets 10 mg once daily orally for a long time due to duodenal ulcer. Due to poor efficacy, the antiepileptic drug was adjusted to sodium valproate sustained-release tablets 0.5 g orally twice daily in combination with levetiracetam 0.25 g orally twice daily, and paroxetine 20 mg orally once daily because of depression was given at the same time. After about 3 months of treatments, the patient repeatedly suffered from limb convulsions, and the laboratory test showed serum sodium 128 mmol/L. Oral and intravenous sodium supplementation were given for 16 days, but his blood sodium level was still less than 130 mmol/L. It was considered that the hyponatremia of the patient might be caused by drugs. After stopping paroxetine, the patient′s blood sodium concentration returned to 140 mmol/L 2 days later.

Objective To study the correlation between lactate/albumin ratio level and incidence of multiple organ dysfunction syndrome (MODS) as well as mortality in patients with severe sepsis or septic shock.Methods In January 2012-September 2013, 54 patients who were admitted to the intensive care unit(ICU) of a hospital developed severe sepsis and septic shock on the first day of admission, clinical data of patients were analyzed.Results On the first and second days of admission, 30(55.56%)and 26(53.06%)patients developed MODS;lactate/albumin ratio between MODS group and non-MODS group on the first and second days of admission were both significantly different (both P<0.05).Multivariate logistic regression analysis showed that lactate/albumin ratio, oxygenation index (PaO2/FiO2), as well as acute physiology and chronic health evaluation (APACHE Ⅱ) were independent risk factors for predicting MODS in patients with severe sepsis.Lactate/albumin ratios between MODS group and non-MODS group, death group and non-death group were both significantly different (both P<0.05);lactate/albumin ratio was correlated with APACHE Ⅱand PaO2/FiO2, the higher the APACHE Ⅱ score and the lower the PaO2/FiO2, the higher of lactate/albumin ratio.The area under the receiver operating curve (ROC curve) analysis showed that incidence and mortality of MODS on the first day of admission predicted by lactate /albumin ratio were 0.85 and 0.84 respectively;sensitivity, specificity, positive predictive value, and negative predictive value of occurrence of MODS predicted by lactate /albumin ratio>1.735 were 80.00%, 79.17%, 82.67%, and 75.92% respectively, sensitivity, specificity, positive predictive value, and negative predictive value of mortality were 100.00%, 51.02%, 17.23%, and 100.00% respectively.Conclusion Lactate/albumin ratio level is closely correlated with incidence and mortality of MODS in patients with severe sepsis or septic shock.

OBJECTIVE: To explore the correlation between snoring and carotid artery plaques in the elderly population. METHOD: Sixty-seven patients with snoring and 61 healthy volunteers accepted questionnaire on sleep apnea were analyzed in the survey. Multivariate Logistic regression analysis was used to analyze the factors affecting carotid artery plaques. RESULT: Among the non-snorers (n = 61), mild snorer (n = 18), moderate snorers (n = 24) and severe snorers (n = 25) groups, the prevalence of carotid artery plaques in four groups were 19.7%, 44.4%, 62.5%, 84.0% respectively. There was statistically significant differences between groups. After multivariable adjustment, the moderate and severe snorers were still risk factors affecting carotid artery plaques, the OR (95% CI) values were 4.378 (1.181-16.225), and 19.572 (3.316-115.528) respectively. CONCLUSION The moderate and severe snoring in the elderly population were relevant to the increased prevalence of carotid artery plaques, and was a risk factor on carotid artery plaques.
Aged ; Carotid Stenosis ; epidemiology ; Female ; Humans ; Logistic Models ; Male ; Prevalence ; Risk Factors ; Snoring ; epidemiology