Based on the theory of "sweet-flavored medicinals retaining and restoring body fluid"， this paper proposed that the core pathogenesis of hypercoagulable state in malignant tumors is qi deficiency and fluid consumption， blood stasis and vessels stagnation， which evolves dynamically according to the pattern "qi deficiency → fluid consumption → blood stasis". Accordingly， a staged treatment system is established with the general principle of "fortifying the middle jiao， restoring fluid and activating blood circulation". In the initial stage， invigorating the spleen and boosting qi to generate body fluid， targeting the onset of middle jiao deficiency and body fluid consumption； in the middle stage， nourishing yin and unblocking collaterals to facilitate body fluid circulation， addressing the disorder of body fluid transportation and collateral injury caused by internal dryness； in the late stage， consolidating yin and resolving blood stasis to retain body fluid， resolving yin impairment， fluid exhaustion， and binding of stasis and toxin. By regulating body fluid metabolism to improve the hypercoagulable state， this system is intended to provide insights for the prevention and treatment of hypercoagulable state in malignant tumors with traditional Chinese medicine.

Tumor is a complex disease,and tumor immune microenvironment(TIME)destabilization is an important factor in tumor occurrence and progression.Based on the Yin Fire theory of traditional Chinese medicine,there is a potential correlation between the imbalance of"Yuan Qi-Yin Fire"and time destabilization and the transformation of tumor immune typing.Injury to the spleen and stomach and insufficient Yuan Qi lead to the endogenous Yin Fire,which is the initiating factor of TIME destabilization;abnormal spleen and stomach transportation and dysfunction of ascending and descending are the core pathogenesis that promotes Yin Fire to rush upward,aggravating the disorder of TIME components;Yin Fire and its pathological products ultimately mediate the transformation of tumor immune typing.The treatment strategies of"performing from the beginning","inheriting and controlling"and"generating and transforming"are proposed,providing a new perspective for tumor-related theoretical research and clinical practice.

Tumor is a complex disease,and tumor immune microenvironment(TIME)destabilization is an important factor in tumor occurrence and progression.Based on the Yin Fire theory of traditional Chinese medicine,there is a potential correlation between the imbalance of"Yuan Qi-Yin Fire"and time destabilization and the transformation of tumor immune typing.Injury to the spleen and stomach and insufficient Yuan Qi lead to the endogenous Yin Fire,which is the initiating factor of TIME destabilization;abnormal spleen and stomach transportation and dysfunction of ascending and descending are the core pathogenesis that promotes Yin Fire to rush upward,aggravating the disorder of TIME components;Yin Fire and its pathological products ultimately mediate the transformation of tumor immune typing.The treatment strategies of"performing from the beginning","inheriting and controlling"and"generating and transforming"are proposed,providing a new perspective for tumor-related theoretical research and clinical practice.