Objective To investigate the effects of clopidogrel combined with edaravone on blood coagulation and neurological functions in patients with acute cerebral infarction .Methods One hundred and twenty cases of acute cerebral infarction that were ad-mitted into the hospital from September 2014 to September 2016 were recruited as research subjects and were randomly divided into the study group and the control group , each consisting of 60 cases.The control group was given clopidogrel treatment , while the study group was given clopidogrel combined with edaravone .The therapeutic effects , blood coagulation and neurological functions of the 2 groups were analyzed.Results After treatment, the blood coagulation function of the patients in the two groups were considerably improved , plasma viscosity, whole blood high viscosity, whole blood low viscosity and fibrinogen were all significantly decreased (P<0.05), and those of the study group showed better improvement (P<0.05).After treatment, neurological deficiency of the 2 groups were more sig-nificantly improved (P<0.05), with the improvement of the study group being superior to that of the control group (P<0.05).Fol-lowing treatment, the effective rate of the 60 cases in the study group was 91.67%, which was significantly higher than that of the con-trol group (73.33%) (P<0.05).Conclusion Clopidogrel combined with edaravone could produce definite effects on acute cerebral infarction, and in the meantime could significantly improve the blood coagulation of the patients with acute cerebral infarction and pro -mote recovery of neurological function as well .