Objective To analyze the research progress of acupuncture and moxibustion in the treatment of simple obesity,thus to provide reference for further research in this field.Methods The relevant literature in China National Knowledge Infrastructure(CNKI)and Wanfang Data Knowledge Service Platform in the past 24 years were retrieved,and analysis of authors,institutions,and keywords were carried out by CiteSpace 6.2.R6 software,and visualization maps were drawn.Results A total of 889 valid articles were included,and the number of annual publications tended to be stable;the authors in this field were Zhou Zhongyu and Chen Xia as the core author team;the most involved research institution in the institutional cooperation map was the Nanjing University of Chinese Medicine;the high-frequency keywords mainly concentrated on"acupuncture therapy","acupuncture and muxibustion therapy","simple obesity","acupoint catgut embedding therapy",etc.;the keyword clusters covered a total of 13 items,namely"electroacupuncture","acupuncture","acupuncture and moxibustion","acupoint catgut embedding",etc.Conclusion There are many studies on acupuncture and moxibustion in the treatment of simple obesity,and the hot spots of the study are focused on small-sample clinical observation,literature research,and research on the mechanism of action.In the future,researchers can conduct further high-quality studies as well as research on the application and mechanism of action of specific acupuncture therapies,with the aim of developing the preferable therapeutic approaches of acupuncture for the treatment of simple obesity.

Based on the theory of"body fluid and blood sharing the same origin",this paper reveals that the core pathogenesis of atopic dermatitis(AD)lies in the abnormal distribution and transformation of body fluid and blood,which is closely related to dysfunction of the lung,spleen,and kidney.Integrating modern medical research on immune regulation and skin barrier function,we propose that in the early stage of AD,due to deficient endowment,acquired loss of nutrition,insufficiency of the spleen and kidney,and failure of the lung-defense system to protect,external pathogens stagnate in the fleshy exterior.This leads to dysfunction of the lung's governance over the skin,impaired distribution of body fluid,obstruction of qi and blood circulation,and stagnation in the skin,resulting in exudative dampness.The dampness stagnates and transforms into heat.Acupuncture should primarily focus on clearing the lung,dispersing stagnation,distributing body fluid,and unblocking collaterals.In the middle and late stages,as lung disease affects the spleen and kidney,acupuncture should emphasize supplementing and tonifying the spleen and kidney,nourishing blood,and moistening dryness,while simultaneously addressing both the root and the branch.For intractable pruritus,fire needling or pricking-collateral cupping can be employed to control itching and reduce recurrence.

Objective:To investigate the effectiveness and safety of endovascular therapy for acute progressive stroke caused by large vessel occlusion (LVO).Methods:Patients with progressive stroke caused by LVO admitted to the Department of Neurology, Yueyang Central Hospital from January 2019 to February 2022 were retrospective included. Patients with an Alberta Stroke Program Early CT Score (ASPECTS) or posterior circulation ASPECTS (pc-ASPECTS) ≥6 after progression were selected for endovascular therapy, including mechanical thromboectomy, thrombus aspiration, balloon angioplasty, stenting, or a combination of the above methods. Patients in the time window (anterior circulation within 12 h and posterior circulation within 24 h) and outside the time window (anterior circulation >12 h, posterior circulation >24 h) as well as those in the anterior and posterior circulation were compared.Results:A total of 20 patients with progressive stroke caused by LVO received endovascular treatment were included. There were 17 males and 3 females, aged 59.45±12.06 years. Three patients (15%) developed asymptomatic intracranial hemorrhage, and 12 (60%) had a good outcome 3 months after procedure. There were no statistically significant differences in the rate of successful vascular recanalization, incidence of intracranial hemorrhage, and the rate of poor outcomes between patients within and outside the time window and between the patients with anterior and posterior circulation.Conclusion:Endovascular therapy may be safe and effective for patients with progressive stroke caused by LVO with ASPECTS or pc-ASPECTS scores ≥6.

OBJECTIVE: To explore the genetic basis for a case of Lamb-Shaffer syndrome. METHODS: Genomic DNA was extracted from peripheral blood samples and subjected to whole exome sequencing(WES). Suspected variant was verified by Sanger sequencing. RESULTS: The patients was found to harbor a heterozygous c.1495delA(p.Thr499Glnfs*5) frameshift variant of the SOX5 gene by WES. Sanger sequencing confirmed that the same variant was a de novo variant. Based on the American College of Medical Genetics and Genomics guidelines, c.1495delA(p.Thr499Glnfs*5) variant of the SOX5 gene was predicted to be pathogenic (PVS1+PS2+PM2). CONCLUSION The c.1495delA(p.Thr499Glnfs*5) variant of the SOX5 gene probably underlies the Lamb-Shaffer syndrome in this patient.
Animals ; Genomics ; Heterozygote ; Humans ; Mutation ; SOXD Transcription Factors/genetics* ; Sheep ; Whole Exome Sequencing

Objective: To explore an effective long non-coding RNA (lncRNA) signature in predicting the prognosis of hepatocellular carcinoma through the analysis on RNA sequencing data of hepatocellular carcinoma patients and peritumoral tissues in the Cancer Genome Atlas (TCGA) database. Methods: The clinical characteristics and RNA sequencing data of 377 hepatocellular carcinoma patients were obtained from TCGA database by the end of February 2018. Then, differentially expressed lncRNAs between 50 pairs of tumor and peritumoral tissues were explored using student’s t-test. Next, a lncRNA signature was established through LASSO Cox regression analysis. All the patients were divided into four groups (<P₂₅, P₂₅-, P₅₀-, ≥P₇₅) based on the cut-off quartiles signature. Finally, compared with the control group (<P₂₅), the hazard ratios (HRs) of three groups (P₂₅-, P₅₀-, ≥P₇₅) were calculated by using Cox regression. The survival outcomes of patients in the four groups were compared to evaluate the capacity of the lncRNA signature model. Results: A total of 951 differentially expressed lncRNAs were identified between tumor and peritumoral tissues. A three-lncRNA signature, including LNCSRLR, MKLN1-AS and ZFPM2-AS1, was established to predict the prognosis of hepatocellular carcinoma patients. The outcome suggested that the death risk of the ≥P₇₅ group was 1.57 times larger than that of the <P₂₅ group (95%CI: 1.06-2.31, P<0.05). Conclusion The three-lncRNA signature, which established by LNCSRLR, MKLN1-AS and ZFPM2-AS1, was significantly associated with the prognosis of hepatocellular carcinoma patients based on TCGA database data.

OBJECTIVETo analyze the risk factors of liver metastasis in patients after radical resection of pancreatic cancer.

METHODSOne hundred and twenty-four patients with non-metastatic, resectable pancreatic cancer treated in our department between 2006 and 2012 were included in this study. All of these patients underwent resection of the primary tumor combined with extensive lymph node dissection. The development of postoperative liver metastases was carefully followed up, and the clinicopathological factors and molecular characteristics were evaluated by univariate analysis and multivariate logistic regression using SPSS 16.0 software.

RESULTSForty-eight cases of liver metastases were found among the 124 cases of pancreatic cancer after radical surgery (38.7%). The rate of liver metastasis of pancreatic cancer after radical surgery in the age groups < 40, 40-60, and > 60 were 68.8%, 33.3% and 35.1%, respectively. The rate of liver metastasis in the body mass index (BMI) group < 20 kg/m2, 20-25 kg/m2, and > 25 kg/m2 were 21.6%, 44.1% and 52.6%, and the rate of liver metastasis in the time between the onset and diagnosis groups ≥ 3 months and < 3 months were 59.4% and 31.5%, respectively. The rate of liver metastasis in patients with preoperative fatty liver was 14.3% and it was 43.7% in patients without preoperative fatty liver. The rate of liver metastasis in patients of histological high, medium and low grade was 10.0%, 35.4% and 49.0%, respectively. The rate of liver metastasis in patients with venous tumor thrombus was 68.8% and it was 34.3% in patients without venous tumor embolus. The rate of liver metastasis in patients with postoperative chemotherapy was 31.2% and it was 51.1% in patients without postoperative chemotherapy. All those differences had statistical significance (P < 0.05). Univariate analysis revealed that age, body mass index (BMI), time between the onset and diagnosis, preoperative fatty liver, histological grading, tumor invasion depth, venous tumor embolus, and postoperative chemotherapy were significantly related to postoperative liver metastasis. Multivariate analysis revealed five statistically independent risk factors for postoperative liver metastasis: BMI, time between onset and diagnosis, preoperative fatty liver, histological grading, and venous tumor embolus.

CONCLUSIONSOur data suggest that patient's BMI, time between onset and diagnosis, histological grade, and venous tumor embolus are significantly correlated with postoperative liver metastases in patients with pancreatic cancer. Pancreatic cancer patients with preoperative fatty liver have less postoperative liver metastasis.

Adult ; Aged ; Body Mass Index ; Humans ; Liver Neoplasms ; secondary ; Lymph Node Excision ; Middle Aged ; Pancreatic Neoplasms ; pathology ; surgery ; Regression Analysis ; Risk Factors

Objective To analyse tratment strategies and to evaluate the relation between different therapies and survival rate of patients of with asynchronous liver metastases after pancreatic cancer surgery (PCLM).Methods From January 2006 to January 2012,48 patients with PCLM were included in this study,and their medical records were retrospectively analyzed.Results Among the 48 patients,27 cases of liver metastases were found within six months after surgery,and the survival rate for 1,3 and 5 years was 22.2％,3.7％ and 0％,respectively,with the median survival of 6 months,and 21 cases of liver metastases were found after six months,and the survival rate for 1,3 and 5 years was 85.7％,30.6％ and 9.2％,with the median survival of 15 months,and the difference between the two groups was statistically significant (P ＜ 0.01).After pancreatic cancer surgery and adjuvant gemcitabine chemotherapy,the probability of liver metastases was 33.3％ (8/24) within six months,the median disease-free survival time was 8 months and the disease-free survival rate for 1,3 and 5 years was 20.8％,4.3％ and 0％.For patients without adjuvant gemcitabine chemotherapy,the probability of liver metastases was 79.2％ (19/24),the median disease-free survival time was 3 months and the disease-free survival rate for 1,3 and 5 years was 4.2％,0％ and 0％,and the difference between the two groups was statistically significant (P ＜ 0.01).The overall survival for patients undergoing resection of liver metastases combined with gemcitabine treatment was better than the other groups (P ＜ 0.01).And the overall survival for patients undergoing transhepatic arterial embolization (TACE) combined with gemcitabine treatment was better than TACE group,gemcitabine group or the observation group (P ＜0.05).There were no difference in overall survival between TACE group,gemcitabine group and observation group.Conclusions Pancreatic cancer patients who develop liver metastasis within six months after surgery have poor prognosis,but postoperative chemotherapy can delay the development of liver metastasis.For patients with resectable lesion,resection of asynchronous liver metastasis is the treatment of choice,and TACE combined with gemcitabine has better efficacy than that of single treatment.

Objective To analyze the risk factors of liver metastasis in patients after radical resection of pancreatic cancer.Methods One hundred and twenty-four patients with nonm-etastatic , resectable pancreatic cancer treated in our department between 2006 and 2012 were included in this study. All of these patients underwent resection of the primary tumor combined with extensive lymph node dissection.The development of postoperative liver metastases was carefully followed up, and the clinicopathological factors and molecular characteristics were evaluated by univariate analysis and multivariate logistic regression using SPSS 16.0 software.Results Forty-eight cases of liver metastases were found among the 124 cases of pancreatic cancer after radical surgery ( 38.7%) .The rate of liver metastasis of pancreatic cancer after radical surgery in the age groups <40, 40-60, and >60 were 68.8%, 33.3%and 35.1%, respectively.The rate of liver metastasis in the body mass index ( BMI) group <20 kg/m2 , 20-25 kg/m2 , and >25 kg/m2 were 21.6%, 44.1%and 52.6%, and the rate of liver metastasis in the time between the onset and diagnosis groups ≥3 months and <3 months were 59.4%and 31.5%, respectively. The rate of liver metastasis in patients with preoperative fatty liver was 14.3%and it was 43.7%in patients without preoperative fatty liver.The rate of liver metastasis in patients of histological high, medium and low grade was 10.0%, 35.4%and 49.0%, respectively.The rate of liver metastasis in patients with venous tumor thrombus was 68.8%and it was 34.3%in patients without venous tumor embolus.The rate of liver metastasis in patients with postoperative chemotherapy was 31.2%and it was 51.1%in patients without postoperative chemotherapy.All those differences had statistical significance ( P<0.05) .Univariate analysis revealed that age, body mass index ( BMI) , time between the onset and diagnosis, preoperative fatty liver, histological grading, tumor invasion depth, venous tumor embolus, and postoperative chemotherapy were significantly related to postoperative liver metastasis.Multivariate analysis revealed five statistically independent risk factors for postoperative liver metastasis: BMI, time between onset and diagnosis, preoperative fatty liver, histological grading, and venous tumor embolus.Conclusions Our data suggest that patient′s BMI, time between onset and diagnosis, histological grade, and venous tumor embolus are significantly correlated with postoperative liver metastases in patients with pancreatic cancer.Pancreatic cancer patients with preoperative fatty liver have less postoperative liver metastasis.

Objective To analyze the risk factors of liver metastasis in patients after radical resection of pancreatic cancer.Methods One hundred and twenty-four patients with nonm-etastatic , resectable pancreatic cancer treated in our department between 2006 and 2012 were included in this study. All of these patients underwent resection of the primary tumor combined with extensive lymph node dissection.The development of postoperative liver metastases was carefully followed up, and the clinicopathological factors and molecular characteristics were evaluated by univariate analysis and multivariate logistic regression using SPSS 16.0 software.Results Forty-eight cases of liver metastases were found among the 124 cases of pancreatic cancer after radical surgery ( 38.7%) .The rate of liver metastasis of pancreatic cancer after radical surgery in the age groups <40, 40-60, and >60 were 68.8%, 33.3%and 35.1%, respectively.The rate of liver metastasis in the body mass index ( BMI) group <20 kg/m2 , 20-25 kg/m2 , and >25 kg/m2 were 21.6%, 44.1%and 52.6%, and the rate of liver metastasis in the time between the onset and diagnosis groups ≥3 months and <3 months were 59.4%and 31.5%, respectively. The rate of liver metastasis in patients with preoperative fatty liver was 14.3%and it was 43.7%in patients without preoperative fatty liver.The rate of liver metastasis in patients of histological high, medium and low grade was 10.0%, 35.4%and 49.0%, respectively.The rate of liver metastasis in patients with venous tumor thrombus was 68.8%and it was 34.3%in patients without venous tumor embolus.The rate of liver metastasis in patients with postoperative chemotherapy was 31.2%and it was 51.1%in patients without postoperative chemotherapy.All those differences had statistical significance ( P<0.05) .Univariate analysis revealed that age, body mass index ( BMI) , time between the onset and diagnosis, preoperative fatty liver, histological grading, tumor invasion depth, venous tumor embolus, and postoperative chemotherapy were significantly related to postoperative liver metastasis.Multivariate analysis revealed five statistically independent risk factors for postoperative liver metastasis: BMI, time between onset and diagnosis, preoperative fatty liver, histological grading, and venous tumor embolus.Conclusions Our data suggest that patient′s BMI, time between onset and diagnosis, histological grade, and venous tumor embolus are significantly correlated with postoperative liver metastases in patients with pancreatic cancer.Pancreatic cancer patients with preoperative fatty liver have less postoperative liver metastasis.