The Expert Consensus on Clinical Application of Qinbaohong Zhike Oral Liquid in Treatment of Acute Bronchitis and Acute Attack of Chronic Bronchitis （GS/CACM 337-2023） was released by the China Association of Chinese Medicine on December 13^th， 2023. This expert consensus was developed by experts in methodology， pharmacy， and Chinese medicine in strict accordance with the development requirements of the China Association of Chinese Medicine （CACM） and based on the latest medical evidence and the clinical medication experience of well-known experts in the fields of respiratory medicine （pulmonary diseases） and pediatrics. This expert consensus defines the application of Qinbaohong Zhike oral liquid in the treatment of cough and excessive sputum caused by phlegm-heat obstructing lung， acute bronchitis， and acute attack of chronic bronchitis from the aspects of applicable populations， efficacy evaluation， usage， dosage， drug combination， and safety. It is expected to guide the rational drug use in medical and health institutions， give full play to the unique value of Qinbaohong Zhike oral liquid， and vigorously promote the inheritance and innovation of Chinese patent medicines.

By combining the origin and research progress of the combination of disease and syndrome, the core pathogenesis, this article explored the research ideas and methods of the core pathogenesis of TCM. It is found that modern TCM is mostly guided by the idea of classification-staging-syndrome differentiation, the main prescription of the main disease, the special prescription of the special disease, and the idea of "dynamic-fixed sequential". The tongue image syndrome differentiation method, clustering analysis method, drug test syndrome method, compound pathogenesis method, "evidence-based pathogenesis-syndrome treatment system" research model, and the integration of traditional Chinese and Western medicine theory were used to explore the core pathogenesis of TCM under the condition of disease. Combined with the advantages of modern medical disease differentiation and TCM syndrome differentiation, the individualized diagnosis and treatment methods of integrated traditional Chinese and Western medicine have been continuously improved, in order to solve the stage contradictions of different clinical stages, effectively delay the progression of the disease and improve the prognosis of the disease.

This study aims to introduce the hotspots of frontier academic achievements into the teaching of undergraduate courses in biomedical engineering. To tackle the existing teaching problems and with the goal of solving engineering problems, we propose the idea of emphasizing innovation, strengthening practice, and highlighting the central position of learners, forming a hybrid teaching model that combines online and offline teaching methods and promotes in-class and out-of-class activities. The reform has shown effectiveness for mobilizing students' enthusiasm for independent learning and enhancing students' comprehensive practical ability and innovative thinking, which provides a reference for cultivating biomedical engineering professionals who meet the new needs of national strategic development.

Objective Corruption is the most common cadaver phenomenon in forensic practice and an important basis for inferring time of death(PMI),but the definition of corruption degree and the construction of model inference models have always been difficult in the practice of forensic science.Methods In this study,the late postmortem phenomena were observed.Meanwhile,the microbial flora structure of gut and gravesoil and the nature of gravesoil were detected,for analyzing the changes before and after the key moment of abdominal rupture which naturally happened during the cadaver decay.Results The results found that from the macroscopic and microscopic levels,there were significant differences in cadaver decay,including microbial flora structure and gravesoil properties before and after the key moment of the natural abdominal rupture during cadaver decay.The phenomena are highly observable and can be accurately judged by forensic examinations,as well as related means in the field of biology and physiochemistry.In this study,this critical event was called Rupture Point.Conclusion The Rupture Point can be used as an important node for the assessment of cadaver decay degree in the practice of forensic medicine.It can be utilized for a cut-off point as well when constructing PMI inference models based on microbial flora structure changes.The accuracy of PMI inference models can be improved when the models were constructed in segments.

BACKGROUND:Platelet-rich fibrin(PRF)is a second generation platelet concentrate with the advantages of simple operation,no anticoagulant,and high bioactivity,which has been applied in the fields of trauma repair,bone defect repair,and tendon soft tissue repair,and has been proved to have a certain tissue repair-promoting effect. OBJECTIVE:To study the repair effect of PRF on articular cartilage tissue in rats with knee osteoarthritis. METHODS:Thirty-six Sprague-Dawley rats were randomly divided into normal group,model group,and PRF group,with 12 rats in each group.Rats in the normal group did not undergo any treatment.In the model group,animal models of knee osteoarthritis were prepared and rat models were then given physiological saline into the joint cavity once a week after surgery.Rat models of knee osteoarthritis were also prepared in the PRF group,and autologous PRF was injected into the joint cavity once a week after surgery.After 5 weeks of continuous treatment,tissue samples were taken.Hematoxylin-eosin staining was used to observe the morphology of cartilage tissue.Tunel staining was used to detect chondrocyte apoptosis,ELISA was used to detect inflammatory factor levels.Western blot and RT-PCR were used to detect Bcl-2,Bax,and Caspase-3 expression in protein and mRNA levels,respectively. RESULTS AND CONCLUSION:The model group had severe cartilage tissue damage,while the PRF group had significantly improved cartilage tissue morphology compared with the model group.The model group had more apoptotic chondrocytes.Compared with the model group,the mean absorbance of Tunel positive staining in the PRF group significantly decreased(P<0.01).The levels of interleukin-1β,interleukin-6 and tumor necrosis factor-α were significantly increased in the model group and PRF group compared with the normal group(P<0.01)and were significantly decreased in the PRF group compared with the model group(P<0.01).The relative expressions of Bax and Caspase-3 at protein and mRNA levels were significantly increased in the model group and PRF group compared with the normal group(P<0.01),while the relative expressions of Bcl-2 at protein and mRNA were significantly decreased(P<0.01).Compared with the model group,the relative expression of Bax and Caspase-3 at protein and mRNA levels were significantly decreased in the PRF group(P<0.01),while the relative expressions of Bcl-2 at protein and mRNA levels were significantly increased(P<0.01).To conclude,PRF can inhibit chondrocyte apoptosis by inhibiting the expression of pro-inflammatory factors,thereby promoting cartilage tissue repair in knee osteoarthritis rats.

At present, there is still a big gap between China and developed countries in the field of high-end medical devices, and the ability of independent innovation needs to be improved. In order to comprehensively cultivate innovative talents in the field of medical devices and promote the development of the field of medical devices, the biomedical engineering major of Chongqing Medical University has put forward a "Trinity" innovative talent training system in the field of medical devices, including the teaching of theoretical knowledge, the improvement of practical skills and the guarantee of the innovation system, and established a four stage curriculum system framework of "Perception-Understanding-Enlightenment-Challenge" to form a characteristic course with ultrasonic treatment equipment as the main line. After three years of practice, the results of this training mode show that the innovative ability, professional connotation construction quality and employment postgraduate entrance examination rate of our college students have been steadily improved. The exploration of this talent training mode has reference significance for the cultivation of innovative talents in the field of medical devices in higher medical colleges and universities in China.

In the practical teaching of large-scale medical equipment courses in medical colleges and universities. There are some problems such as less opportunities for students to operate the equipment which is possessed by teaching hospitals, the large-scale medical equipment in teaching hospitals are in a pathogenic environment, and some equipment such as CT, DR have radiation hazards, which lead to difficulties in practical teaching. These problems restrict the cultivation of students' practical ability, cause disconnections between theoretical teaching and practical teaching, and are not conducive to training "new engineering" and "new medical science" talents. So, this paper puts forward an idea which introduces virtual simulation teaching instruments of large-scale medical equipment into the teaching of medical equipment in medical colleges and universities, uses the physical structures, control systems and functional software of virtual simulation teaching instruments to implement the teaching of "integration of theory and practice", and also sets up validation experiments, comprehensive experiments, designing experiments and research explorative experiments in the teaching process. This kind of teaching can not only realize the high integration of theoretical teaching and practical teaching, but also consolidate students' basic theoretical knowledge, improve their abilities to solve complex engineering problems, and cultivate "new engineering" and "new medical" talents in line with the needs of the new era.

Objective To explore the effects of accessory hyperbaric oxygen ( HBO) therapy on pain, serum 5 serotonin (5-HT) and P substance (PS) in the patients with calcaneal fractures. Methods Fifty-four patients with Sanders II, III and IV calcaneal fractures hospitalized from May 2016 to May 2018 were enrolled for the study, and they were randomly divided into the control group and the observation group, each consisting of 27 patients. The control group received routine treatment in accordance with the practice during perioperative period after calcaneal fracture, while the observation group was given HBO treatment in addition to the treatment received by the control group. Visual analogue scores ( VAS) at different time points before and after surgery, serum 5-HT and PS levels, rate of complication during perioperative period and SF-36 scores 3 and 6 months after surgery and AOFAS were compared between the patients of the 2 groups. Results The visual analogue scores after surgery were significantly higher than those before surgery for the patients of the 2 groups, however, the scores 5 and 7 days after surgery obviously decreased, and those of the observation group were lower than those of the control group. Statistical significance could be noted when comparisons were made between the 2 groups (P<0. 05). The serum 5-HT and PS levels 3 days after surgery all elevated significantly in the patients of the 2 groups, and the serum 5-HT and PS levels 5 and 7 days after surgery in the observation group were obviously lower than those of the control group(P<0. 05). AOFAS However, the scores of the above indicators 6 months after surgery in the observation group were significantly higher than those of the control group, with statistical significance(P<0. 05). The rate of complications in the observation group (11. 1％)was obviously lower than that of the control group(40. 7％), also with statistical significance(P <0. 01). Conclusion Accessory HBO therapy could effectively reduce serum 5-ht and PS levels in the patients with calcaneal fractures, alleviate postoperative pain and lower the rate of complications after surgery.

Objective To explore the effects of accessory hyperbaric oxygen ( HBO) therapy on pain, serum 5 serotonin (5-HT) and P substance (PS) in the patients with calcaneal fractures. Methods Fifty-four patients with Sanders II, III and IV calcaneal fractures hospitalized from May 2016 to May 2018 were enrolled for the study, and they were randomly divided into the control group and the observation group, each consisting of 27 patients. The control group received routine treatment in accordance with the practice during perioperative period after calcaneal fracture, while the observation group was given HBO treatment in addition to the treatment received by the control group. Visual analogue scores ( VAS) at different time points before and after surgery, serum 5-HT and PS levels, rate of complication during perioperative period and SF-36 scores 3 and 6 months after surgery and AOFAS were compared between the patients of the 2 groups. Results The visual analogue scores after surgery were significantly higher than those before surgery for the patients of the 2 groups, however, the scores 5 and 7 days after surgery obviously decreased, and those of the observation group were lower than those of the control group. Statistical significance could be noted when comparisons were made between the 2 groups (P<0. 05). The serum 5-HT and PS levels 3 days after surgery all elevated significantly in the patients of the 2 groups, and the serum 5-HT and PS levels 5 and 7 days after surgery in the observation group were obviously lower than those of the control group(P<0. 05). AOFAS However, the scores of the above indicators 6 months after surgery in the observation group were significantly higher than those of the control group, with statistical significance(P<0. 05). The rate of complications in the observation group (11. 1％)was obviously lower than that of the control group(40. 7％), also with statistical significance(P <0. 01). Conclusion Accessory HBO therapy could effectively reduce serum 5-ht and PS levels in the patients with calcaneal fractures, alleviate postoperative pain and lower the rate of complications after surgery.

Cervical spondylosis is due to degenerative cervical disc and its stimulation or oppression of the adjacent nerves, spinal cord, spinal artery and other tissue caused by clinical symptoms. The cervical spine is an anatomical structure with activity, while the pillow has a certain plastic fixation effect on the cervical spine anatomy. Therefore, the pillow not only plays a health role in the cervical spine, but also plays an important role in restoring the normal physiological curvature of the cervical spine. Based on this, a multi-functional cervical vertebra treatment pillow is designed, which not only has the functions of traction, maintaining different positions of the cervical spine, correcting the cervical curvature and equipment exercises, but also has the functions of voice broadcast and network data terminal.