Objective:To explore the predictive value of neutrophil-to-lymphocyte ratio (NLR) combined with platelet-to-lymphocyte ratio (PLR) in early stage of systemic inflammatory response syndrome (SIRS) in children.Methods:A total of 136 children with SIRS (SIRS group) and 120 healthy children (control group) diagnosed and treated in the Eighth People′s Hospital of Hefei from January 2021 to February 2023 were retrospectively selected as the study objects. Inflammatory response indicators and peripheral blood NLR and PLR levels were compared between the two groups. Pearson test was used to analyze the correlation between NLR and PLR and other inflammatory response indicators in children with SIRS. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of NLR and PLR alone and combined detection for SIRS.Results:The levels of serum procalcitonin (PCT), C-reactive protein (CRP) and interleukin-6 (IL-6) in the SIRS group were higher than those in the control group: (1.56 ± 0.41) μg/L vs. (0.57 ± 0.15) μg/L, (56.04 ± 17.71) mg/L vs. (4.50 ± 1.38) mg/L, (8.54 ± 1.95) ng/L vs. (0.95 ± 0.21) ng/L, there were statistical differences ( P<0.05). The levels of NLR and PLR of peripheral blood in the SIRS group were higher than those in the control group: 4.08 ± 1.32 vs. 2.01 ± 0.58, 269.15 ± 80.09 vs. 194.01 ± 62.41, there were statistical differences ( P<0.05). The results of Pearson test showed that the levels of NLR and PLR of peripheral blood were positively correlated with the levels of serum PCT, CRP and IL-6 ( r = 0.245, 0.540, 0.492, 0.282, 0.365, 0.721, P<0.05). The ROC curve analysis results showed that the area under the curve of the combined NLR and PLR detection to predict SIRS was 0.747(95% CI 0.650 -0.828), which was higher than the single index. Conclusions:The levels of NLR and PLR of peripheral blood are related to the incidence of SIRS in children. The combined prediction of the two index can further improve the accuracy of early prediction.

Objective:To explore the predictive value of neutrophil-to-lymphocyte ratio (NLR) combined with platelet-to-lymphocyte ratio (PLR) in early stage of systemic inflammatory response syndrome (SIRS) in children.Methods:A total of 136 children with SIRS (SIRS group) and 120 healthy children (control group) diagnosed and treated in the Eighth People′s Hospital of Hefei from January 2021 to February 2023 were retrospectively selected as the study objects. Inflammatory response indicators and peripheral blood NLR and PLR levels were compared between the two groups. Pearson test was used to analyze the correlation between NLR and PLR and other inflammatory response indicators in children with SIRS. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of NLR and PLR alone and combined detection for SIRS.Results:The levels of serum procalcitonin (PCT), C-reactive protein (CRP) and interleukin-6 (IL-6) in the SIRS group were higher than those in the control group: (1.56 ± 0.41) μg/L vs. (0.57 ± 0.15) μg/L, (56.04 ± 17.71) mg/L vs. (4.50 ± 1.38) mg/L, (8.54 ± 1.95) ng/L vs. (0.95 ± 0.21) ng/L, there were statistical differences ( P<0.05). The levels of NLR and PLR of peripheral blood in the SIRS group were higher than those in the control group: 4.08 ± 1.32 vs. 2.01 ± 0.58, 269.15 ± 80.09 vs. 194.01 ± 62.41, there were statistical differences ( P<0.05). The results of Pearson test showed that the levels of NLR and PLR of peripheral blood were positively correlated with the levels of serum PCT, CRP and IL-6 ( r = 0.245, 0.540, 0.492, 0.282, 0.365, 0.721, P<0.05). The ROC curve analysis results showed that the area under the curve of the combined NLR and PLR detection to predict SIRS was 0.747(95% CI 0.650 -0.828), which was higher than the single index. Conclusions:The levels of NLR and PLR of peripheral blood are related to the incidence of SIRS in children. The combined prediction of the two index can further improve the accuracy of early prediction.