Neurofibromatosis type 1 (NF1) presents with a diverse range of symptoms that can affect the skin, bones, eyes, central nervous system, and other organs. This article reports the diagnosis and treatment process of a patient with NF1 complicated by bilateral severe-to-profound sensorineural hearing loss. Genetic testing revealed a heterozygous variant of NF1 NM_ 000267.3: c.4054_ 4058del(p.Ser1352LeufsTer20, supporting the diagnosis of NF1. After thorough evaluation, a right cochlear implantation was performed, yielding satisfactory postoperative results. This case suggests that NF1 patients may exhibit phenotypic heterogeneity and atypicality, providing a reference for clinicians in the diagnosis and treatment of such patients.

To conduct a systematic analysis of a clinical surgery theoretical examination based on knowledge points, thereby providing a reference for establishing a scientific and comprehensive test paper analysis system.

In recent years, the number of patients with vaginal relaxation has increased year by year, and the minimally invasive vaginal contraction has been carried out more and more widely in clinical practice, but the treatment normalization and safety have not been thoroughly studied. We summarized six cases of characteristics and treatment measures for patients with various complications after minimally invasive vaginal contraction surgery from September 2021 to December 2023 at Department of Plastic and Aesthetic Surgery, Peking Union Medical College Hospital. The patients' age ranged from 26 to 44 years. Two cases accepted vaginal contraction with embedded vaginal thread, and four accepted vaginal contraction with acellular allogenic dermis. One patient showed vaginal hyper-tightness, one patient showed subcutaneous suture nodules, two patients showed explosion of acellular allogenic dermis, and three patients showed vaginal infection symptoms such as yellow leucorrhea and peculiar smell. All patients had sexual pain and discomfort. One patient underwent vaginal orifice dilation, one patient underwent suture extraction and secondary vaginal contraction, one patient underwent acellular allogenic dermis extraction and immediate vaginal contraction, two patients underwent acellular allogenic dermis extraction and secondary vaginal contraction, and one patient underwent secondary vaginal contraction. The symptoms of all six patients were relieved after treatment. Despite the short operation time and fast postoperative recovery of minimally invasive vaginal contraction, there are still complications after surgery, causing physical and mental damage to patients. Plastic surgeons, therefore, should be cautious in the treatment process to avoid collateral damage, so that patients get the best treatment effect.

In recent years, the number of patients with vaginal relaxation has increased year by year, and the minimally invasive vaginal contraction has been carried out more and more widely in clinical practice, but the treatment normalization and safety have not been thoroughly studied. We summarized six cases of characteristics and treatment measures for patients with various complications after minimally invasive vaginal contraction surgery from September 2021 to December 2023 at Department of Plastic and Aesthetic Surgery, Peking Union Medical College Hospital. The patients' age ranged from 26 to 44 years. Two cases accepted vaginal contraction with embedded vaginal thread, and four accepted vaginal contraction with acellular allogenic dermis. One patient showed vaginal hyper-tightness, one patient showed subcutaneous suture nodules, two patients showed explosion of acellular allogenic dermis, and three patients showed vaginal infection symptoms such as yellow leucorrhea and peculiar smell. All patients had sexual pain and discomfort. One patient underwent vaginal orifice dilation, one patient underwent suture extraction and secondary vaginal contraction, one patient underwent acellular allogenic dermis extraction and immediate vaginal contraction, two patients underwent acellular allogenic dermis extraction and secondary vaginal contraction, and one patient underwent secondary vaginal contraction. The symptoms of all six patients were relieved after treatment. Despite the short operation time and fast postoperative recovery of minimally invasive vaginal contraction, there are still complications after surgery, causing physical and mental damage to patients. Plastic surgeons, therefore, should be cautious in the treatment process to avoid collateral damage, so that patients get the best treatment effect.

Objective:To identify a new type of hypertrophy of the clitoral hood-labia minora complex(CLC), to propose a classification system for the hypertrophy, and to evaluate surgical techniques and clinical outcomes for fused lateral clitoral hood and labia minora.Methods:A retrospective analysis was conducted on clinical data from patients who underwent labiaplasty surgery at the Department of Plastic and Aesthetic Surgery, Peking Union Medical College Hospital from January 2013 to October 2023. CLC hypertrophy was classified into three types based on whether the CLC was hypertrophic and their free edges fused. Type Ⅰ: isolated labia minora hypertrophy; Type Ⅱ: independent lateral clitoral hood and labia minora hypertrophy; Type Ⅲ: fused type of lateral clitoral hood and labia minora hypertrophy. Type Ⅲ patients were divided into a wedge excision group and a four-step excision group. A satisfaction survey was conducted three months postoperatively using the Goodman female genital aesthetic surgery questionnaire, distributed online to evaluate the surgical outcomes based on vulvar appearance improvement rate, preoperative discomfort improvement rate, postoperative discomfort rate, sexual quality improvement rate, partner satisfaction, and overall satisfaction. Statistical analysis was performed using SPSS 26.0 software, with normal distribution data presented as Mean±SD, intergroup comparisons conducted using t-test, and count data expressed as frequency and(or) percentage with chi-square tests. A P-value < 0.05 was considered statistically significant. Results:A total of 651 female patients (1 243 sides) with CLC hypertrophic deformities were enrolled, aged 18-55 years, with a mean age of 30.7 years. Type Ⅰ consisted of 198 patients with 301 sides(24.22%), Type Ⅱ consisted of 420 patients with 743 sides(59.77%), and Type Ⅲ consisted of 116 patients with 199 sides(16.01%). Some patients had different classifications of CLC on the left and right sides. Among the Type Ⅲ patients, 22 cases were in the wedge resection group and 94 cases in the four-step resection group. Three months postoperatively, 112 patients (195 sides) out of 116 Type Ⅲ patients (199 sides) completed the satisfaction survey. The wedge resection group had 22 patients (44 sides), with an age of (31.6±5.2) years, and the four-step resection group had 90 patients (151 sides), with an age of (32.6±5.5) years. There was no statistically significant difference in age between the two groups ( P>0.05). The four-step resection group had significantly higher vulvar appearance improvement rate [61.11%(55/90) vs. 22.73%(5/22)], preoperative discomfort improvement rate[92.68%(76/82) vs. 58.82%(10/17)], and overall satisfaction [90.00% (81/90) vs. 68.18% (15/22)] compared to the wedge resection group ( P<0.05 for all). The four-step resection group had a sexual quality improvement rate of 21.05%(16/76) and partner satisfaction of 91.14% (72/79), which were not statistically different from the wedge resection group [12.50%(2/16) and 75.00% (12/16)]( P>0.05 for both). The proportion of patients with postoperative discomfort in the four-step resection group was 8.89% (8/90), significantly lower than the 31.82% (7/22) in the wedge resection group ( P< 0.05). There was no statistically significant difference in complication rate between the four-step resection group [2.65% (4/151)] and the wedge resection group [4.55% (2/44)]. Conclusion:CLC hypertrophy can be classified based on clitoral hood and labia minora hypertrophy and fusion type, including isolated labia minora hypertrophy, independent lateral clitoral hood and labia minora hypertrophy, and fused type of lateral clitoral hood and labia minora hypertrophy. The four-step excision method for correcting fused type of lateral clitoral hood and labia minora hypertrophy yields excellent surgical outcomes, low complication rates, and high patient satisfaction.

Objective:To improve and optimize the modified surgical strategies for patents with Simon Ⅰ and Simon Ⅱ type of gynecomastia, based on their magnetic resonance imaging (MRI) features.Methods:Clinical data of 190 patients aged 12 to 56 years (mean age 26.7±8.6) with gynecomastia who underwent modified surgeries in the Department of Plastic Surgery of Peking Union Medical College Hospital from January 2017 to January 2023 were retrospectively analyzed. The study measured breast MRI images of 44 male patients to calculate the area ratio of the glands on the transverse plane via nipple. This provided insight into the physiological structure and the tissue distribution of gynecomastia for improving the modified surgical strategies. All 190 patients were treated with enhanced liposuction and " Pull-Through and Bottom-Up" techniques. The duration of operation, amount of liposuction and amount of glandular resection, postoperative complications were recorded, and postoperative satisfaction was investigated by questionnaire surveys.Results:MRI images of the 87-side male breast showed that the average area ratio of the glands on the transverse plane via nipple was (10.9±12.5) %. The most prevalent subtype of gynecomastia was branch pattern, accounting for 46.0%. The median surgical duration of 190 patients was 95 (65-210) minutes, the median liposuction volume was 300 (50-1 400) ml, and the median glandular removal was 19.9 (1.5-157.0) g. Eighty-eight patients (46.3%) went through followed up for more than 6 months post-posterative with an overall satisfaction score of 4.68±0.53. Postoperative complications occurred in 19 sides (5.1%), and the reoperation rate was 1.3%.Conclusions:The MRI imaging of gynecomastia shows that the component of patients′ breasts are mainly fat, with a small amount of glandular tissue and the dominant subtype is branch pattern. Enhanced liposuction combined with " Pull-Through and Bottom-Up" stab incision technique can be an effective treatment for Simon grades Ⅰ and Ⅱ gynecomastia. The method results in high patient satisfaction with fewer postoperative complications.

Objective:To evaluate the differences and aesthetic meaning of stable vitiligo treatment in the face and neck region using suction blister transplantation or noncultured autologous suspension of epidermal cells.Methods:Sixty-four stable vitiligo patients (25 males and 39 females with age ranges from 10 to 46 years, average 25 years) in the face and neck region were randomly divided into two groups (32 patients in each group): one group received suction blister transplantation, while other group received noncultured autologous suspension of epidermal cells. Patients′treatment effectiveness, pigmentation and piecing deformity were evaluated in postoperative 3 months and 6 months.Results:In the postoperative 3 months and 6 months, the effectiveness of suction blister transplantation group was 68.75% (22/32) and 90.63% (29/32), respectively, while the effectiveness of noncultured autologous suspension of epidermal cells group was 59.37% (19/32) and 87.50% (28/32), respectively, in which no significant differences were found between two groups ( P>0.05). No obvious pigmentation and piecing deformity were found in noncultured autologous suspension of epidermal cells group, which were much better than the suction blister transplantation group in postoperative 3 months and 6 months. Conclusions:Both suction blister transplantation and noncultured autologous suspension of epidermal cells could bring good treatment effectiveness for patients of stable vitiligo in the face and neck region. Compared with suction blister transplantation, noncultured autologous suspension of epidermal cells could offer better aesthetic appearance.

Objective:To summarize the clinical diagnosis and treatment process of breast implant associated-anaplastic large cell lymphoma (BIA-ALCL) in symptomatic patients with textured breast implants in Peking Union Medical College Hospital in order to provide reference for the management of such patients in China.Methods:From January 2019 to September 2021, 23 symptomatic patients with textured breast implants were admitted to the Peking Union Medical College Hospital, aged 29-52 years, with an average of 36.2 years. All patients agreed to remove the prosthesis by surgery, and accepted cytology, flow cytometry, and immunohistochemical examination of the fluid around the implants and capsule tissue before or during the operation to complete the BIA-ALCL screening process.Results:All 23 patients presented with unilateral periprosthetic fluid accumulation, with fluid volume ranging from 20 to 130 ml, of which 7 cases were combined with periprosthetic contracture. No tumor cells were found in the pathological findings of effusion and the capsule tissue, and the BIA-ALCL pathologic screening results (CD 30 and ALK) were all negative. No bleeding, infection, wound dehiscence and other complications occurred after the operation.Conclusions:A personalized clinical process should be developed for symptomatic patients with textured breast implants. Attention should be paid to imaging and pathological examinations.

Objective:To identify a new type of hypertrophy of the clitoral hood-labia minora complex(CLC), to propose a classification system for the hypertrophy, and to evaluate surgical techniques and clinical outcomes for fused lateral clitoral hood and labia minora.Methods:A retrospective analysis was conducted on clinical data from patients who underwent labiaplasty surgery at the Department of Plastic and Aesthetic Surgery, Peking Union Medical College Hospital from January 2013 to October 2023. CLC hypertrophy was classified into three types based on whether the CLC was hypertrophic and their free edges fused. Type Ⅰ: isolated labia minora hypertrophy; Type Ⅱ: independent lateral clitoral hood and labia minora hypertrophy; Type Ⅲ: fused type of lateral clitoral hood and labia minora hypertrophy. Type Ⅲ patients were divided into a wedge excision group and a four-step excision group. A satisfaction survey was conducted three months postoperatively using the Goodman female genital aesthetic surgery questionnaire, distributed online to evaluate the surgical outcomes based on vulvar appearance improvement rate, preoperative discomfort improvement rate, postoperative discomfort rate, sexual quality improvement rate, partner satisfaction, and overall satisfaction. Statistical analysis was performed using SPSS 26.0 software, with normal distribution data presented as Mean±SD, intergroup comparisons conducted using t-test, and count data expressed as frequency and(or) percentage with chi-square tests. A P-value < 0.05 was considered statistically significant. Results:A total of 651 female patients (1 243 sides) with CLC hypertrophic deformities were enrolled, aged 18-55 years, with a mean age of 30.7 years. Type Ⅰ consisted of 198 patients with 301 sides(24.22%), Type Ⅱ consisted of 420 patients with 743 sides(59.77%), and Type Ⅲ consisted of 116 patients with 199 sides(16.01%). Some patients had different classifications of CLC on the left and right sides. Among the Type Ⅲ patients, 22 cases were in the wedge resection group and 94 cases in the four-step resection group. Three months postoperatively, 112 patients (195 sides) out of 116 Type Ⅲ patients (199 sides) completed the satisfaction survey. The wedge resection group had 22 patients (44 sides), with an age of (31.6±5.2) years, and the four-step resection group had 90 patients (151 sides), with an age of (32.6±5.5) years. There was no statistically significant difference in age between the two groups ( P>0.05). The four-step resection group had significantly higher vulvar appearance improvement rate [61.11%(55/90) vs. 22.73%(5/22)], preoperative discomfort improvement rate[92.68%(76/82) vs. 58.82%(10/17)], and overall satisfaction [90.00% (81/90) vs. 68.18% (15/22)] compared to the wedge resection group ( P<0.05 for all). The four-step resection group had a sexual quality improvement rate of 21.05%(16/76) and partner satisfaction of 91.14% (72/79), which were not statistically different from the wedge resection group [12.50%(2/16) and 75.00% (12/16)]( P>0.05 for both). The proportion of patients with postoperative discomfort in the four-step resection group was 8.89% (8/90), significantly lower than the 31.82% (7/22) in the wedge resection group ( P< 0.05). There was no statistically significant difference in complication rate between the four-step resection group [2.65% (4/151)] and the wedge resection group [4.55% (2/44)]. Conclusion:CLC hypertrophy can be classified based on clitoral hood and labia minora hypertrophy and fusion type, including isolated labia minora hypertrophy, independent lateral clitoral hood and labia minora hypertrophy, and fused type of lateral clitoral hood and labia minora hypertrophy. The four-step excision method for correcting fused type of lateral clitoral hood and labia minora hypertrophy yields excellent surgical outcomes, low complication rates, and high patient satisfaction.

Objective:To compare the pros and cons of harvesting ear cartilage through anterior and posterior auricular approaches during rhinoplasty.Methods:From January 2017 to December 2018, 63 patients with otochondral rhinoplasty in our hospital were enrolled in this study, 60 were female and 3 were male; the average age was 31.6 years (range, 18 to 43) . They were randomly divided into anterior auricular approach group with 32 cases (64 sides) and posterior auricular approach group with 31 cases (62 sides). Surgical duration, complications and postoperative scar of the two methods were analyzed.Results:The average time for harvesting the ear cartilage through posterior auricular approach and anterior auricular approach was (20.8±1.7) min and (12.6±1.1) min, respectively ( P<0.01). The overall complication rate was 15.6% for posterior auricular approach group and 4.8% for anterior auricular approach group. The wound healed well in both groups, and there was no significant difference in postoperative scar between the two groups during an average 13 months follow-up period. Conclusions:While both the anterior and the posterior auricular approaches present with similar inconspicuous scarring, the use of anterior auricular approach alone to harvest ear cartilage during rhinoplasty provides both the surgeons and the patients with easier access, shorter surgical duration, and fewer complications. Hence, we believe that the anterior auricular approach possesses greater advantages than the posterior auricular approach.