A 62-year-old male patient was hospitalized with bullous pemphigoid.He received prednisone 15 mg thrice daily,loratadine 10 mg once daily,and cefradine 0.5 g thrice daily by mouth as well as symptomatic and supportive therapy.Three days later,occasional agitation appeared in the patient.However,he did not receive any treatment.Seven days later,the dose of prednisone was increased to 60 mg/d for poor control of rash.Eight days later,he experienced anxiety,dysphoria,agitation,persecutory delusion,abnormal behavior,memory loss,and occasional failure to recognise location.The dose of prednisone was then decreased to 45 mg/d.Loratadine was discontinued.He was switched to oral cyproheptadine 2 mg thrice daily,and other therapy was the same as before.One week later,the patient's psychiatric symptoms gradually relieved and he was discharged.The dose of prednisone was gradually reduced and then stopped 45 days after discharge.The patient had no recurrence of similar psychiatric symptoms at a 3-month follow-up.

A 62-year-old male patient was hospitalized with bullous pemphigoid.He received prednisone 15 mg thrice daily,loratadine 10 mg once daily,and cefradine 0.5 g thrice daily by mouth as well as symptomatic and supportive therapy.Three days later,occasional agitation appeared in the patient.However,he did not receive any treatment.Seven days later,the dose of prednisone was increased to 60 mg/d for poor control of rash.Eight days later,he experienced anxiety,dysphoria,agitation,persecutory delusion,abnormal behavior,memory loss,and occasional failure to recognise location.The dose of prednisone was then decreased to 45 mg/d.Loratadine was discontinued.He was switched to oral cyproheptadine 2 mg thrice daily,and other therapy was the same as before.One week later,the patient's psychiatric symptoms gradually relieved and he was discharged.The dose of prednisone was gradually reduced and then stopped 45 days after discharge.The patient had no recurrence of similar psychiatric symptoms at a 3-month follow-up.