Abstract Close contacts of rifampicin-resistant or multidrug-resistant tuberculosis (RR/MDR-TB) patients are at high risk of latent tuberculosis infection (LTBI) and active TB. Preventive treatment for this group is a key strategy to block the spread of drug-resistant TB. Levofloxacin is a core fluoroquinolone anti-TB drug. It has good antibacterial activity, pharmacokinetic properties, and safety. It can significantly reduce the risk of progression to active TB in close contacts of RR/MDR-TB patients. Therefore, it is an important candidate drug for preventive treatment. Based on evidence from the TB-CHAMP and V-QUIN trials, the World Health Organization (WHO) recommended a 6-month levofloxacin regimen in 2024 for preventive treatment in close contacts of RR/MDR-TB patients. This paper searched for literature from 2000 to 2026. It reviews the clinical efficacy, dose optimization in adults and children, and safety of levofloxacin in preventive treatment for close contacts of drug-resistant TB patients. The aim is to provide evidence for optimizing drug-resistant TB control.

OBJECTIVETo increase local blood supply of bone graft, a novel posterior lumbar spine fusion method with orthotopic paraspinal muscle-pediculated bone flaps was constructed, and the fusion rate and clinical effect.were observed.

METHODSFrom June 2007 to December 2010, 117 patients of lumbar spinal stenosis or lumbar destabilization treated with the novel posterior lumbar fusion method were studied, 49 males and 68 females, aged from 40 to 77 years, average 61.5 years. Clinical effect was evaluated by JOA and VAS score preoperatively and postoperatively, and the fusion result was evaluated by three-dimensional CT reconstruction postoperatively.

RESULTSSeventeen cases lost of follow up, the rest were followed up from 7 to 38 months, average 19 months. There was significant difference between pre- and postoperative JOA and VAS score (P < 0.01), the preoperative JOA score was 10.3 ± 1.9, and 25.4 ± 4.2 at the latest follow-up, the improvement rate was 81.0% ; the preoperative VAS score was 8.5 ± 0.8, and 2.3 ± 0.4 at the latest follow-up. The three-dimensional CT reconstruction showed that 126 of the 133 segments formed solid fusion in 100 patients who completed the follow-up, the fusion rate was 94.7%.

CONCLUSIONThe novel posterior lumbar fusion method make the bone graft position more precise, stable and increases the fusion rate, which can effectively reduce pseudarthrosis and have a promising clinical effect.

Adult ; Aged ; Bone Transplantation ; Female ; Follow-Up Studies ; Humans ; Lumbar Vertebrae ; Male ; Middle Aged ; Spinal Fusion ; methods ; Spinal Stenosis ; surgery ; Treatment Outcome