Tumor immunotherapy has attracted worldwide attention in cancer treatment because of its obvious advantages such as strong specificity and long curative effect.It is found that activation of STING signaling pathway in cells is one of directions to effec-tively realize tumor immunotherapy.However,due to low response rate of related drugs,difficult degradation,certain toxic and side effects,its clinical application has been seriously hindered.Nano-drug delivery system can achieve targeted drug delivery,improve drug stability,delivery rate,osmotic effect and long-term retention effect,reduce drug side effects,and show significant advantages in tumor immunotherapy.In this paper,research progress of nano-drug delivery system activating STING pathway in tumor immunother-apy in recent years is reviewed,and many nano-drug delivery systems that can activate STING signal pathway and their application ex-amples after loading drugs are listed,including nucleotide-based drug delivery system,non-nucleotide-based drug delivery system and metal-based drug delivery system,providing reference for application of nano-drugs in tumor immunotherapy.

Tumor immunotherapy has attracted worldwide attention in cancer treatment because of its obvious advantages such as strong specificity and long curative effect.It is found that activation of STING signaling pathway in cells is one of directions to effec-tively realize tumor immunotherapy.However,due to low response rate of related drugs,difficult degradation,certain toxic and side effects,its clinical application has been seriously hindered.Nano-drug delivery system can achieve targeted drug delivery,improve drug stability,delivery rate,osmotic effect and long-term retention effect,reduce drug side effects,and show significant advantages in tumor immunotherapy.In this paper,research progress of nano-drug delivery system activating STING pathway in tumor immunother-apy in recent years is reviewed,and many nano-drug delivery systems that can activate STING signal pathway and their application ex-amples after loading drugs are listed,including nucleotide-based drug delivery system,non-nucleotide-based drug delivery system and metal-based drug delivery system,providing reference for application of nano-drugs in tumor immunotherapy.

The selection of suturing techniques and suture materials is a common problem in general surgery. In 2008,the Chinse Society of Surgery of Chinese Medical Association draw up the first edition of The Chinese Consensus Statement on General surgical suture technique and suture material. In the last ten years, it has appeared antibacterial sutures, drug elution lines, barbed lines, anti-leakage needles, stabresistant needles, bio-3D staplers in suture materials, which promoted the development of general surgery. At the same time, with the advancement of surgical techniques and the application of laparoscopic and robotic surgery, suture techniques such as triangular anastomosis and nondisconnected Roux-en-Y anastomosis have appeared. This article reviews the progress of new suture materials, introduces the achievements of suturing technique in general surgery, and discusses the significance of the 2018 edition of The Chinese Consensus Statement on General Surgical Suture Technique and Suture Material.