1.The historical responsibility of Chinese medical ethics in the process of promoting a community with a shared future for mankind
Chinese Medical Ethics 2025;38(1):95-102
Reflecting on the historical responsibility of Chinese medical ethics at present, it is necessary to place oneself in the grand context of promoting the process of building a community with a shared future for mankind. Safety, development, and civilization constitute the three important ethical dimensions of a community with a shared future for mankind, which are not only ethical orientations, but also ethical appeals. These provide an important direction for Chinese medical ethics to deeply consider its role in the process of a community with a shared future for mankind. The historical responsibilities of Chinese medical ethics in the process of promoting a community with a shared future for mankind mainly include: confronting moral and interest issues, adhering to the patient-centered approach, and ensuring patients’ life safety; playing the role of ethical regulation, achieving the practical effects of medical ethics, and maintaining social security and stability; implementing the responsibility of medical ethics education, shaping medical professionalism, and promoting the development of healthy China; inheriting the excellent traditional culture, pursuing medical excellence and justice, and promoting the development of social morality; pursuing common health values, building a community with a shared future between doctors and patients, and promoting the progress of human. A global community of health for all provides the most direct practical platform for Chinese medical ethics to fulfill its historical responsibility in the process of building a community with a shared future for mankind. It directly promotes Chinese medical ethics to the world, and Chinese ethics facing the world will play an increasingly important influence in self-renewal.
2.Erratum: Author correction to "SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade" Acta Pharm Sin B 9 (2019) 304-315.
Mingxia ZHAO ; Wenjie GUO ; Yuanyuan WU ; Chenxi YANG ; Liang ZHONG ; Guoliang DENG ; Yuyu ZHU ; Wen LIU ; Yanhong GU ; Yin LU ; Lingdong KONG ; Xiangbao MENG ; Qiang XU ; Yang SUN
Acta Pharmaceutica Sinica B 2025;15(5):2810-2812
[This corrects the article DOI: 10.1016/j.apsb.2018.08.009.].
3.The impact of lens capsule diameter and capsular tension ring fit on the rota-tional stability of Toric IOLs in high myopia patients
Yanhui XU ; Keqing MENG ; Xiaojing LIU ; Yumeng CHEN ; Yuyu GUO ; Jiayu LI ; Zhimin CHEN
Recent Advances in Ophthalmology 2025;45(9):725-730
Objective To evaluate the impact of lens capsule diameter and capsular tension ring(CTR)fit on the ro-tational stability and visual function of Toric intraocular lenses(IOLs)in patients with high myopia cataract after surgery,and to explore the main influencing factors.Methods A prospective study included 100 eyes of patients with high myopia(axial length≥26 mm)who underwent phacoemulsification cataract extraction combined with Toric IOL implantation at the Cataract Department of Hebei Eye Hospital from September 2023 to March 2024.Based on the ratio of the capsule equivalent diameter measured by anterior segment OCT(CASIA2)to the standard diameter of CTR,the eyes were divided into the matched group(ratio of 0.8-1.2)and the unmatched group.Follow-up was conducted at 1 week,1 month,3 months,6 months,and 12 months postoperatively to observe the rotation angle of Toric IOL,residual astigmatism,uncor-rected visual acuity,and other indicators.Safety was assessed based on intraoperative and postoperative complications.Correlation analysis and multiple linear regression were used to explore the impact of capsule-CTR fit,corneal astigmatism,axial length,and other factors on Toric IOL rotation and postoperative refractive status.Results The mean IOL rotation angle at each postoperative time point in the matched group was significantly smaller than that in the unmatched group,with statistically significant differences between groups at different time points(all P<0.05).The matched group showed better stability in IOL decentration distance and tilt angle.At 12 months postoperatively,the residual astigmatism in the matched group was(0.53±0.29)D,which was better than that in the unmatched group(0.71±0.34)D(P=0.08).The matched group also had more significant improvement in uncorrected visual acuity and higher subjective visual quality scores.Multiple linear regression analysis showed that capsule-CTR fit and preoperative corneal astigmatism were the main independent factors affecting the rotation angle of Toric IOL(R2=0.52)and residual astigmatism(R2=0.46).Conclu-sion For patients with high myopia cataract,precise capsule-CTR matching based on CASIA2 measurement helps improve the rotational stability of Toric IOLs,reduce residual astigmatism,and enhance postoperative visual quality.Personalized CTR model selection is worth promoting and applying.
4.Latent class analysis and influencing factors of intrinsic capacity in hospitalized older adults
Yuyu WANG ; Jie ZHANG ; Aimin GUO
Chinese Journal of Modern Nursing 2025;31(13):1760-1767
Objective:To explore the latent classes of intrinsic capacity and their influencing factors among hospitalized older adults, providing a basis for developing targeted intervention strategies.Methods:A convenience sampling method was used to recruit 371 hospitalized older adults from Beijing Hospital between April 2022 and July 2023. The integrated care for older people comprehensive assessment tool was used to assess the intrinsic capacity of hospitalizd older adults, along with grip strength tests. Latent class analysis (LCA) was employed to classify the intrinsic capacity of hospitalizd older adults, and multinomial Logistic regression analysis was conducted to explore the influencing factors of different latent classes.Results:Among the 371 older adults, 78.98% (293/371) exhibited declines in various dimensions of intrinsic capacity, with impairment detection rates of 36.39% (135/371) in cognition, 34.23% (127/371) in mobility, 21.02% (78/371) in vitality, 33.69% (125/371) in psychological well-being, and 47.98% (178/371) in sensory function. The LCA results identified three latent classes of intrinsic capacity: high mobility-moderate sensory group (39.08%, 145/371) , low cognition-high mobility group (26.68%, 99/371) , and low mobility group (34.23%, 127/371) . Multinomial Logistic regression analysis revealed that age, gender, monthly family income, polypharmacy, and grip strength were influencing factors of the latent classes of intrinsic capacity ( P<0.05) . Conclusions:The intrinsic capacity of hospitalized older adults is heterogeneous. It is essential to promptly identify the characteristics of intrinsic capacity in different groups, with particular attention to older adults in the low cognition-high mobility group and low mobility group, and implement targeted interventions to prevent and improve adverse outcomes.
5.Research progress on integrated care for older people in the context of healthy aging
Aimin GUO ; Yuyu WANG ; Qian DONG
Chinese Journal of Modern Nursing 2025;31(22):2941-2946
Population aging has become a major global challenge. The World Health Organization (WHO) proposed the concept of healthy aging and issued the integrated care for older people (ICOPE) guidelines, aiming to mitigate or reverse the decline in intrinsic capacity among older adults through person-centered integrated care pathways, thereby maintaining optimal functional ability. Many countries have initiated ICOPE implementation tailored to their national contexts and have achieved encouraging outcomes. These include improvements in older adults' functional status through multidimensional assessment and early intervention, reduced healthcare utilization, and enhanced self-management abilities. This review summarizes the theoretical foundations and current research progress of integrated care for older people, providing a reference for the implementation of healthy aging strategies in China.
6.The impact of lens capsule diameter and capsular tension ring fit on the rota-tional stability of Toric IOLs in high myopia patients
Yanhui XU ; Keqing MENG ; Xiaojing LIU ; Yumeng CHEN ; Yuyu GUO ; Jiayu LI ; Zhimin CHEN
Recent Advances in Ophthalmology 2025;45(9):725-730
Objective To evaluate the impact of lens capsule diameter and capsular tension ring(CTR)fit on the ro-tational stability and visual function of Toric intraocular lenses(IOLs)in patients with high myopia cataract after surgery,and to explore the main influencing factors.Methods A prospective study included 100 eyes of patients with high myopia(axial length≥26 mm)who underwent phacoemulsification cataract extraction combined with Toric IOL implantation at the Cataract Department of Hebei Eye Hospital from September 2023 to March 2024.Based on the ratio of the capsule equivalent diameter measured by anterior segment OCT(CASIA2)to the standard diameter of CTR,the eyes were divided into the matched group(ratio of 0.8-1.2)and the unmatched group.Follow-up was conducted at 1 week,1 month,3 months,6 months,and 12 months postoperatively to observe the rotation angle of Toric IOL,residual astigmatism,uncor-rected visual acuity,and other indicators.Safety was assessed based on intraoperative and postoperative complications.Correlation analysis and multiple linear regression were used to explore the impact of capsule-CTR fit,corneal astigmatism,axial length,and other factors on Toric IOL rotation and postoperative refractive status.Results The mean IOL rotation angle at each postoperative time point in the matched group was significantly smaller than that in the unmatched group,with statistically significant differences between groups at different time points(all P<0.05).The matched group showed better stability in IOL decentration distance and tilt angle.At 12 months postoperatively,the residual astigmatism in the matched group was(0.53±0.29)D,which was better than that in the unmatched group(0.71±0.34)D(P=0.08).The matched group also had more significant improvement in uncorrected visual acuity and higher subjective visual quality scores.Multiple linear regression analysis showed that capsule-CTR fit and preoperative corneal astigmatism were the main independent factors affecting the rotation angle of Toric IOL(R2=0.52)and residual astigmatism(R2=0.46).Conclu-sion For patients with high myopia cataract,precise capsule-CTR matching based on CASIA2 measurement helps improve the rotational stability of Toric IOLs,reduce residual astigmatism,and enhance postoperative visual quality.Personalized CTR model selection is worth promoting and applying.
7.Latent class analysis and influencing factors of intrinsic capacity in hospitalized older adults
Yuyu WANG ; Jie ZHANG ; Aimin GUO
Chinese Journal of Modern Nursing 2025;31(13):1760-1767
Objective:To explore the latent classes of intrinsic capacity and their influencing factors among hospitalized older adults, providing a basis for developing targeted intervention strategies.Methods:A convenience sampling method was used to recruit 371 hospitalized older adults from Beijing Hospital between April 2022 and July 2023. The integrated care for older people comprehensive assessment tool was used to assess the intrinsic capacity of hospitalizd older adults, along with grip strength tests. Latent class analysis (LCA) was employed to classify the intrinsic capacity of hospitalizd older adults, and multinomial Logistic regression analysis was conducted to explore the influencing factors of different latent classes.Results:Among the 371 older adults, 78.98% (293/371) exhibited declines in various dimensions of intrinsic capacity, with impairment detection rates of 36.39% (135/371) in cognition, 34.23% (127/371) in mobility, 21.02% (78/371) in vitality, 33.69% (125/371) in psychological well-being, and 47.98% (178/371) in sensory function. The LCA results identified three latent classes of intrinsic capacity: high mobility-moderate sensory group (39.08%, 145/371) , low cognition-high mobility group (26.68%, 99/371) , and low mobility group (34.23%, 127/371) . Multinomial Logistic regression analysis revealed that age, gender, monthly family income, polypharmacy, and grip strength were influencing factors of the latent classes of intrinsic capacity ( P<0.05) . Conclusions:The intrinsic capacity of hospitalized older adults is heterogeneous. It is essential to promptly identify the characteristics of intrinsic capacity in different groups, with particular attention to older adults in the low cognition-high mobility group and low mobility group, and implement targeted interventions to prevent and improve adverse outcomes.
8.Research progress on integrated care for older people in the context of healthy aging
Aimin GUO ; Yuyu WANG ; Qian DONG
Chinese Journal of Modern Nursing 2025;31(22):2941-2946
Population aging has become a major global challenge. The World Health Organization (WHO) proposed the concept of healthy aging and issued the integrated care for older people (ICOPE) guidelines, aiming to mitigate or reverse the decline in intrinsic capacity among older adults through person-centered integrated care pathways, thereby maintaining optimal functional ability. Many countries have initiated ICOPE implementation tailored to their national contexts and have achieved encouraging outcomes. These include improvements in older adults' functional status through multidimensional assessment and early intervention, reduced healthcare utilization, and enhanced self-management abilities. This review summarizes the theoretical foundations and current research progress of integrated care for older people, providing a reference for the implementation of healthy aging strategies in China.
9.Differences of clinical characteristics between temporal lobe epilepsy with bilateral hippocampal sclerosis and temporal lobe epilepsy with unilateral hippocampal sclerosis
Qi TAO ; Chenmin HE ; Jingjing QIU ; Yuyu YANG ; Sha XU ; Yi GUO ; Hong LI ; Yao DING ; Meiping DING ; Shuang WANG
Chinese Journal of Neuromedicine 2024;23(5):450-457
Objective:To compare the differences of clinical characteristics of temporal lobe epilepsy with bilateral hippocampal sclerosis (TLE-bHS) with those of temporal lobe epilepsy with unilateral hippocampal sclerosis (TLE-uHS).Methods:A retrospective analysis was performed. Forty-eight patients with confirmed TLE-bHS enrolled in Epilepsy Center, Department of Neurology, Second Affiliated Hospital, Medical School of Zhejiang University from January 2013 to January 2022 were chosen, and 101 patients with confirmed TLE-uHS admitted to our hospital at the same time period were selected as controls. Clinical data such as onset age, disease course, past medical history, seizure frequency, anti-seizure medications, video EEG and neuropsychological test results, and outcomes were analyzed.Results:Compared with the TLE-uHS group, the TLE-bHS group had higher male proportion, elder onset age, shorter disease course, higher seizure frequency, more types of past and currently used anti-seizure medications, lower proportion of autonomic nerve with aura, higher proportion of no aura at onset, higher proportion of slow head background movement in video EEG, and lower memory quotient, verbal memory scores and non-verbal memory scores, with significant differences ( P<0.05); the differences in ratio of past medical history and ratio of distributions of regions with interictal epileptiform abnormalities between the 2 groups were statistically significant ( P<0.05): the TLE-bHS group had significantly higher proportion of previous intracranial infection/encephalitis and higher ratio of bilateral temporal epileptiform abnormalities than the TLE-uHS group, while the TLE-uHS group had significantly higher proportion of patients with febrile convulsion history and higher ratio of unilateral temporal epileptiform abnormalities ( P<0.05). Only 10 patients (20.8%) in the TLE-bHS group received non-drug therapy, including anterior temporal lobectomy in 3 patients (Engel grading I in postoperative follow-up for 2 years), neuroregulatory therapy in 4, and ketogenic diet in 4; of the 55 patients (54.5%) in the TLE-uHS group who underwent anterior temporal lobectomy, 48 patients (87.3%) had Engel grading I, 1 patient (1.8%) had grading II, 4 (7.3%) had grading III, and 2 (3.6%) had grading IV after 2 years of follow-up. Conclusion:Differences in onset age, disease course, past medical history, seizure frequency, anti-seizure medications, and video EEG and neuropsychological test results can help to discriminate patients with TLE-bHS or with TLE-uHS.
10.Guidelines for Ideological and Political Teaching of the Doctor-patient Communication Courses
Jinfan WANG ; Mei YIN ; Huan LIU ; Aiming ZHENG ; Yue ZHANG ; Yuyu GUO ; Yuanyuan GUAN
Chinese Medical Ethics 2023;36(6):703-708
To promote the ideological and political construction of the doctor-patient communication course, the research group discussed the subject characteristics and proposed the goals, principles, elements, and paths of the ideological and political construction of the doctor-patient communication course combined with practical teaching and relevant policy documents. Besides, this paper put forward the top-level framework design for the implementation, curriculum assessment, and evaluation indicators of the ideological and political construction, and developed the Guidelines for Ideological and Political Teaching of the Doctor-patient Communication Course and related teaching evaluation indicators, with a view to providing reference evaluation standards for the ideological and political construction of the doctor-patient communication course in China.

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