Arthroplasty, Replacement, Knee ; Humans ; Knee Joint/surgery* ; Leg ; Lower Extremity/diagnostic imaging* ; Osteoarthritis, Knee/surgery* ; Rotation ; Tibia/surgery*

Objective To investigate effect of basal blood glucose level on 18F-FDG PET/CT image quality and its nursing.Methods Hyperglycemia patients who underwent PET/CT examination were screened and were randomly divided into general treatment group (group A) and insulin intensive treatment group (group B),and control group (group C).Hepatic image noise was calculated using the standard uptake (SUV) at different levels of the liver.The relationship between glycosylated serum albumin (GSP) levels and image quality was compared between groups.Results Group A had significantly lower GSP than group B (P ＜ 0.05).There was significant difference in image quality in three groups (P ＜ 0.05).There was no significant difference in noise in group A and group C (P ＞ 0.05).Group B was statistically significant when compared with group C and group A (P ＜ 0.05).Conclusion Intensive insulin therapy can significantly improve the quality of 18F-FDG PET/CT image.

Objective To investigate effect of basal blood glucose level on 18F-FDG PET/CT image quality and its nursing.Methods Hyperglycemia patients who underwent PET/CT examination were screened and were randomly divided into general treatment group (group A) and insulin intensive treatment group (group B),and control group (group C).Hepatic image noise was calculated using the standard uptake (SUV) at different levels of the liver.The relationship between glycosylated serum albumin (GSP) levels and image quality was compared between groups.Results Group A had significantly lower GSP than group B (P ＜ 0.05).There was significant difference in image quality in three groups (P ＜ 0.05).There was no significant difference in noise in group A and group C (P ＞ 0.05).Group B was statistically significant when compared with group C and group A (P ＜ 0.05).Conclusion Intensive insulin therapy can significantly improve the quality of 18F-FDG PET/CT image.

BACKGROUND: Studies have shown that sodium hyaluronate inhibits cartilage damage in osteoarthritis and accelerates regeneration of cartilage cels, to stabilize and repair the articular cartilage.
OBJECTIVE:To investigate the therapeutic effect of sodium-rich plasma combined with platelet-rich plasma (PRP) on rabbit knee osteoarthritis.
METHODS:Forty New Zealand white rabbits were randomly divided into five groups, control group, combined group, sodium hyaluronate group, PRP group and model group, and then an osteoarthritis model of the right knee was made in each rabbit. After modeling, sodium hyaluronate+PRP, sodium hyaluronate, autologous PRP and normal saline were givenviathe knee joint cavity in the latter four groups, respectively, once a week for 5 weeks. The control group received no treatment, as normal controls. At 1 week after treatment, ELISA assay was used to detect serum interleukin-1, interleukin-6, tumor necrosis factor-α levels, and changes of the articular cartilage were observed under a light microscope.
RESULTS AND CONCLUSION:Compared with the control group, the levels of interleukin-1, interleukin-6 and tumor necrosis factor-α were al increased in the other four groups (P < 0.01). Compared with the model group, the levels of interleukin-1, interleukin-6 and tumor necrosis factor-α were lowered significantly in the combined, sodium hyaluronate and PRP groups (P< 0.01 orP< 0.05), and the most significant decline was in the combined group. Articular cartilage damage was severest in the model group and mildest in the combined group. Experimental findings indicate that intra-articular injection of sodium hyaluronate+PRP can reduce inflammation and protect the articular cartilage in knee osteoarthritis, which is better than a single drug injection.

Objective The study is designed to evaluate the difference in identification for depression and clinical effectiveness of its treatment between psychiatrists and non-psychiatric Dhysieians at out-patient departments of general hospitals and to analyze its related factors.Methods Totally,680 patients who visited psychiatric clinics in nine general hospitals of Shanghai at first time were screened by psychiatrists using Composite International Diagnostic Interview(CIDI)for depression and the screening resuhs were compared to the diagnosis made by non-psychiatric physicians as goal-keepers there.Altogether 297 patients with depression were recruited and assessed using Hamilton Depression Rating Scale(HAMD)and Hamilton Anxiety Rating Scale(HAMA).A self-made questionnaire for basic information was used to assess the ability for identification of depression in non-psychiatric physicians of general hospitals.Results Psychiatrists identified depression correctly in 337 of 680 patients who visited psychiatric clinics in general hospitals at their first visit,but non-psychiatric physicians only identified 216 patients,with statistically significant difference(χ2=30.73,P=0.000).A consistent agreement on depression diagnosis between the findings by psychiatrists and by CIDI was reached with Kappa of 0.774,but Kappa for that between the findings by non-psychiatric physicians and CIDI was 0.439.Effectiveness of treatment for depression by psychiatrists was better than that by non-psychiatric physicians,with higher total score and scores for each item of HAMD four,eight and 12 weeks after treatment,respectively(P＜0.05 or P＜0.01).Length of professional work of non-psychiatric physicians and annual time for professional training in management of mental disorders associated with their ability of identification for depression(P＜0.05).Conclusion Ability of non-psychiatric physicians to identify alQd cope with depression in the psychiatric department of general hospitals was insufficient,suggesting that more importance should be attached to the management of service quality at psychiatric department of general hospitals.