Objective:To systematic evaluate the correlation between arsenic and Alzheimer's disease (AD).Methods:Literature search was conducted using China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, PubMed, Science Direct, Web of Science, and Cochrane Library to collect relevant literature on the correlation between arsenic and AD published domestically and internationally. The time limit was from the establishment of the database to February 1, 2024. Meta-analysis was conducted using RevMan 5.3 software, heterogeneity test was conducted using I2 statistic and Q-test, and random effects model or fixed effects model were used for comprehensive quantitative analysis based on heterogeneity results. Standard mean difference ( SMD) was used as the effect indicator and subgroup analysis was conducted based on detection markers and disease progression. Results:The final results included 10 articles (including 1 235 AD patients and 1 293 healthy controls), all of which were in English. After heterogeneity testing, significant heterogeneity was found in the results of each study ( I2 = 78%, P < 0.001). A random effects model was used for meta-analysis, and the combined SMD value (95% CI) was 0.58 (0.45, 0.70). The sub group analysis of detection markers showed that compared with the healthy controls the SMD values (95% CI) of urine arsenic, blood arsenic, ventricular fluid arsenic, frontal cortex arsenic, hair arsenic, nail arsenic, groundwater arsenic, and brain arsenic in AD patients were 5.02 (- 2.09, 12.14), 0.40 (- 0.02, 0.83), 5.00 (- 0.35, 10.35), - 14.00 (- 27.92, - 0.08), 0.75 (0.21, 1.29), 1.42 (0.48, 2.35), - 0.10 (- 0.48, 0.28), and 0.57 (0.36, 0.78), respectively. The sub group analysis of disease progression showed that that compared with the healthy controls the SMD values (95% CI) of arsenic content in mild, moderate, and severe AD patients were 0.88 (0.52, 1.24), 0.57 (0.24, 0.91), and 2.13 (0.26, 4.00), respectively. Conclusion:There is a correlation between arsenic and AD, and hair arsenic and nail arsenic can serve as potential important indicators for evaluating the correlation between arsenic and AD.

Objective:To systematic evaluate the correlation between arsenic and Alzheimer's disease (AD).Methods:Literature search was conducted using China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, PubMed, Science Direct, Web of Science, and Cochrane Library to collect relevant literature on the correlation between arsenic and AD published domestically and internationally. The time limit was from the establishment of the database to February 1, 2024. Meta-analysis was conducted using RevMan 5.3 software, heterogeneity test was conducted using I2 statistic and Q-test, and random effects model or fixed effects model were used for comprehensive quantitative analysis based on heterogeneity results. Standard mean difference ( SMD) was used as the effect indicator and subgroup analysis was conducted based on detection markers and disease progression. Results:The final results included 10 articles (including 1 235 AD patients and 1 293 healthy controls), all of which were in English. After heterogeneity testing, significant heterogeneity was found in the results of each study ( I2 = 78%, P < 0.001). A random effects model was used for meta-analysis, and the combined SMD value (95% CI) was 0.58 (0.45, 0.70). The sub group analysis of detection markers showed that compared with the healthy controls the SMD values (95% CI) of urine arsenic, blood arsenic, ventricular fluid arsenic, frontal cortex arsenic, hair arsenic, nail arsenic, groundwater arsenic, and brain arsenic in AD patients were 5.02 (- 2.09, 12.14), 0.40 (- 0.02, 0.83), 5.00 (- 0.35, 10.35), - 14.00 (- 27.92, - 0.08), 0.75 (0.21, 1.29), 1.42 (0.48, 2.35), - 0.10 (- 0.48, 0.28), and 0.57 (0.36, 0.78), respectively. The sub group analysis of disease progression showed that that compared with the healthy controls the SMD values (95% CI) of arsenic content in mild, moderate, and severe AD patients were 0.88 (0.52, 1.24), 0.57 (0.24, 0.91), and 2.13 (0.26, 4.00), respectively. Conclusion:There is a correlation between arsenic and AD, and hair arsenic and nail arsenic can serve as potential important indicators for evaluating the correlation between arsenic and AD.