The problem of single educational origin structure generally existed in affiliated hospitals of universities, which could not only affect the academic vitality and scientific research innovation ability of the hospital, but also may lead to restricted discipline development. Through measures such as reforming the hospital-retention policy, expanding recruitment channels, strengthening talent cultivation and formulating supporting policies, Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology has successfully increased the proportion of doctors graduated from other hospitals, promoted the diversification of educational origin structure. The author suggested that affiliated hospitals of universities should establish a diversified human resources allocation system during the recruitment stage, give support policies to employees graduated from other hospitals, pay attention to the balanced development of sub-specialties, and expand the educational origin of existing employees, so as to promote the healthy development of clinical disciplines.

Objective:To investigate the status quo of mobile phone addiction, social anxiety, sleep quality, safe behavior and the influence of mobile phone addiction on safe behavior of nursing students in practice, so as to provide evidence for improving the safety behavior of nursing students in practice.Methods:A total of 700 nursing students from The First Affiliated Hospital of Zhengzhou University from March 1 to 20, 2023 were selected by cluster sampling method. A cross-sectional investigation was conducted using the general data questionnaire, the Smartphone Addiction Scale-Short Version, the Nurse Safety Behavior Scale, the Social Anxiety Scale and the Pittsburgh Sleep Quality Index.Results:A total of 678 valid questionnaires were collected, with an effective recovery rate of 96.9%. Among the 678 nursing students in practice, 87 were male and 591 were female, aged (21.25±1.16) years old. The scores of safety behavior, mobile phone addiction, social anxiety and sleep quality of 678 nursing students were (52.33±7.31), (28.21±9.86), (41.92±7.64) and (4.56±2.79) respectively. Mobile phone addiction had a statistically significant effect on the prediction of safety behavior ( β = - 0.178, P<0.01). Social anxiety had an intermediate effect between mobile phone addiction and safety behavior, and the indirect effect accounted for 25.5%. Sleep quality could buffer the influence of social anxiety on safety behavior ( β = 0.022, P<0.05). Conclusions:The safety behaviors of student nurses are good, and there are phenomena of mobile phone addiction and social anxiety. Nursing managers and educators can effectively manage the mobile phones of nursing studentsin practice, reduce their social anxiety and improve their sleep quality, so as to improve the safety behaviors of nursing students in practice and ensure the safety of patients.

OBJECTIVE To explore the protective effect of marein against alcoholic fatty liver （AFL） and its potential mechanisms. METHODS AFL mice model was established with strong wine by gavage. The mice were randomly divided into normal control group （n＝9， 0.5% sodium carboxymethyl cellulose solution）， model group （n＝10， 0.5% sodium carboxymethyl cellulose solution） and marein 75 and 150 mg/kg groups （n＝9）. Mice were given relevant medicine intragastrically， once a day， for consecutive 30 days. After the last medication， the levels of triglyceride （TG）， malondialdehyde （MDA）， and superoxide dismutase （SOD） in liver tissue were determined， and hepatic histopathological changes of liver tissue were observed； the protein expression levels of peroxisome proliferator-activated receptor α （PPARα）， carnitine palmitoyltransferase-1 （CPT-1）， and diacylglycerol acyltransferase （DGAT） were determined in liver tissue. BRL hepatocytes injury model was induced by ethanol combined with ferrous sulfate and oleic acid； after treatment with 3， 6 and 12 μmol/L of marein for 24 h， the distribution of lipid droplets， the levels of TG， MDA and SOD and protein expressions of PPARα， CPT-1 and DGAT in hepatocytes were examined. After pretreatment with MK886 （PPARα inhibitor， 10 μmol/L），modeled hepatocytes were treated with 12 μmol/L of marein for 24 h， and the protein expressions of PPARα， CPT-1 and DGAT were determined. RESULTS As the results showed in vivo， compared with the model group， after treatment with 75 and 150 mg/kg of marein， the degree of steatosis was significantly reduced， and the levels of TG and MDA and protein expression of DGAT were significantly decreased（P＜0.05 or P＜0.01）； the levels of SOD， protein expressions of PPARα and CPT-1 were significantly increased（P＜0.05 or P＜0.01）. As the results showed in vitro， after treatment with 3， 6 and 12 μmol/L of marein， the lipid accumulation of hepatocytes was significantly inhibited， and the levels of TG and MDA， protein expression of DGAT were significantly decreased（P＜0.05 or P＜0.01）， while the levels of SOD， protein expressions of PPARα and CPT-1 were significantly increased（P＜0.05 or P＜0.01）. After MK886 pretreatment， the effects of marein on the above protein expressions were abolished. CONCLUSIONS Marein might exert a protective effect against AFL. The mechanisms might be related to inhibiting oxidative stress-mediated injury and improving PPARα-mediated lipid metabolism signaling pathway.

The problem of single educational origin structure generally existed in affiliated hospitals of universities, which could not only affect the academic vitality and scientific research innovation ability of the hospital, but also may lead to restricted discipline development. Through measures such as reforming the hospital-retention policy, expanding recruitment channels, strengthening talent cultivation and formulating supporting policies, Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology has successfully increased the proportion of doctors graduated from other hospitals, promoted the diversification of educational origin structure. The author suggested that affiliated hospitals of universities should establish a diversified human resources allocation system during the recruitment stage, give support policies to employees graduated from other hospitals, pay attention to the balanced development of sub-specialties, and expand the educational origin of existing employees, so as to promote the healthy development of clinical disciplines.

Objective:To explore and analyze the application effects of multi-site Mini-clinical Evaluation Exercise (Mini-CEX) method in teaching of orthopedic nursing interns.Methods:From September 2019 to December 2019, a total of 97 nursing students who took an internship in 4 Orthopedic Wards of the First Affiliated Hospital of Zhengzhou University were selected as research objects. Among them, 45 nursing students who took an internship in the First Ward and the Second Ward of Orthopedics were set as the control group and other 52 nursing students who took an internship in the Third Ward and the Sixth Ward of Orthopedics were set as the observation group. The control group was given routine nursing instruction, while the observation group was given multi-site Mini-CEX method on the basis of the control group. Scores of all dimensions of Mini-CEX and scores of departmental rotation examination after the completion of teaching and the scores of teaching efficacy of teachers before and after the implementation of multi-site Mini-CEX method were compared between the two groups.Results:Scores of all dimensions and the total score of Mini-CEX of nursing interns in the observation group were higher than those in the control group, and the differences were statistically significant ( P<0.05) . The scores of theoretical assessment and practical operation of departmental rotation examination of nursing students in the observation group were higher than those of the control group, and the differences were statistically significant ( P<0.05) . After the implementation of multi-site Mini-CEX teaching program, the general teacher efficacy, personal teaching efficacy and total scores of nursing teachers were higher than those before the implementation, and the differences were statistically significant ( P<0.05) . Conclusions:Application of multi-site Mini-CEX method in surgical nursing practice teaching can improve clinical skills, comprehensive ability and learning interest of nursing students, and also help to improve the teaching efficacy of teachers, which is worthy of promotion and application.

To investigate the effects of oxymatrine injection (OI) combined with low-dose paclitaxel on expressions of mRNAs and proteins of vascular endothelial growth factor (VEGF) and CXC chemokine receptor 4 (CXCR4) in human gastric carcinoma SGC-7901 cells.