ObjectiveTo develop a patient-reported traditional Chinese medicine kidney deficiency pattern (TCM-KDP) scale for colorectal cancer (CRC) patients and evaluate its reliability and validity.MethodsWe administered the TCM-KDP questionnaire to postoperative patients with stage II and III CRC as part of a multicenter randomized controlled trial (RCT) conducted in China from December 2018 to September 2021. The TCM-KDP scale consists of eight items on patient-reported symptoms and is scored on a five-point Likert scale. The scale’s reliability was assessed using Cronbach’s α and test-retest reliability, while content validity was evaluated with the content validity index. We compared the differences in serum cytokine levels and other clinical factors between patients with higher and lower KDP scores.ResultsOf the 378 patients analyzed in the original RCT, 352 (93.2%) completed the TCM-KDP questionnaire. The Cronbach’s α of the eight-item TCM-KDP scale was 0.734, and the test-retest reliability was 0.745. Our exploratory factor analysis yielded eight factors that explained the variance of 50.34%. The mean TCM-KDP score was 2.80 ± 0.92. Compared with patients with stage II CRC, those with stage III CRC had significantly higher TCM-KDP scores (2.25 vs. 2.50, P = .026). We categorized all patients into high- or low-KDP score groups (the cut-off score was 2.8). Patients with lower TCM-KDP scores had significantly higher serum interleukin-1β expression levels (P = .04).ConclusionThe patient-reported TCM-KDP scale demonstrated relatively good feasibility, internal consistency, and test-retest reliability among patients with CRC. Future studies could apply this scale to other cancer types and diseases.

Colorectal cancer is a common malignant tumor in the gastrointestinal tract,belonging to the categories of traditional Chinese medicine such as"intestinal obstruction","anal locking hemorrhoids",and"intestinal addiction".Professor Yang Yufei created a"two-stage trilogy"therapy based on the occurrence of different side effects during chemotherapy,and is skilled in syndrome differentiation and treatment to strengthen the role of conventional Western medicine treatment and reduce its side effects.Professor Yang Yufei's traditional Chinese medicine for the treatment of chemotherapy side effects in colorectal cancer provides a new approach to clinical medication,with reasonable drug addition and reduction,precise dosage,and significant therapeutic effect.

Objective This study was aimed to explore the characteristic distribution of Post-COVID Conditions in cancer patients and observe the occurrence of Post-COVID Conditions after the intervention of Yinsang granules.Methods This study was a retrospective clinical observation,and a total of 1026 patients in Yang Yufei's outpatient department from January to February 2023 were screened,including 444 malignant tumor patients infected with COVID-19,among which 265 patients received intervention with Yinsang granules.The main observation indicator was the characteristic distribution of Post-COVID Conditions in malignant tumor patients,and the secondary observation indicator was the incidence of Post-COVID Conditions after intervention with Yinsang granules.Results A total of 444 patients with malignant tumors were included in this study,including 198 males(44.6％)and 246 females(55.4％).Average age 59.95±12.45;The five symptoms with the highest frequency of Post-COVID Conditions were fatigue,cough,dyspnea,insomnia and palpitation.The incidence of Post-COVID Conditions was higher in females than in males,and the difference was statistically significant(P＜0.05).The average age of Post-COVID Conditions is higher than that of non-Post-COVID Conditions(62 vs 58),and the age difference between the two groups was statistically significant(P＜0.05).The risk of developing Post-COVID Conditions in breast cancer patients was 2.9 times higher than that in colon cancer patients(P＜0.05).Yinsang granule,female and gastric cancer were the protective factors for the Post-COVID Conditions(P＜0.05).The incidence of Post-COVID Conditions was lower in the group taking Yinsang granule than in the group not taking it,and the difference was statistically significant between the two groups(P＜0.05).Conclusion Yinsang Granule intervention can reduce the incidence of Post-COVID Conditions in tumor patients.

Colorectal cancer is a common malignant tumor in the gastrointestinal tract,belonging to the categories of traditional Chinese medicine such as"intestinal obstruction","anal locking hemorrhoids",and"intestinal addiction".Professor Yang Yufei created a"two-stage trilogy"therapy based on the occurrence of different side effects during chemotherapy,and is skilled in syndrome differentiation and treatment to strengthen the role of conventional Western medicine treatment and reduce its side effects.Professor Yang Yufei's traditional Chinese medicine for the treatment of chemotherapy side effects in colorectal cancer provides a new approach to clinical medication,with reasonable drug addition and reduction,precise dosage,and significant therapeutic effect.

Objective This study was aimed to explore the characteristic distribution of Post-COVID Conditions in cancer patients and observe the occurrence of Post-COVID Conditions after the intervention of Yinsang granules.Methods This study was a retrospective clinical observation,and a total of 1026 patients in Yang Yufei's outpatient department from January to February 2023 were screened,including 444 malignant tumor patients infected with COVID-19,among which 265 patients received intervention with Yinsang granules.The main observation indicator was the characteristic distribution of Post-COVID Conditions in malignant tumor patients,and the secondary observation indicator was the incidence of Post-COVID Conditions after intervention with Yinsang granules.Results A total of 444 patients with malignant tumors were included in this study,including 198 males(44.6％)and 246 females(55.4％).Average age 59.95±12.45;The five symptoms with the highest frequency of Post-COVID Conditions were fatigue,cough,dyspnea,insomnia and palpitation.The incidence of Post-COVID Conditions was higher in females than in males,and the difference was statistically significant(P＜0.05).The average age of Post-COVID Conditions is higher than that of non-Post-COVID Conditions(62 vs 58),and the age difference between the two groups was statistically significant(P＜0.05).The risk of developing Post-COVID Conditions in breast cancer patients was 2.9 times higher than that in colon cancer patients(P＜0.05).Yinsang granule,female and gastric cancer were the protective factors for the Post-COVID Conditions(P＜0.05).The incidence of Post-COVID Conditions was lower in the group taking Yinsang granule than in the group not taking it,and the difference was statistically significant between the two groups(P＜0.05).Conclusion Yinsang Granule intervention can reduce the incidence of Post-COVID Conditions in tumor patients.

Objective:To explore the potential target and signaling pathway of Sijunzi Decoction in treating Colorectal Cancer (CRC) with network pharmacology.Methods:The Traditional Chinese Medicine System Platform (TCMSP) and Swiss Target Prediction database were adopted to establish the database of Sijunzi Decoction effective ingredients and targets. Therapeutic Target Database (TTD), Online Mendelian Inheritance in Man, Drugbank and GeneCards were used to build the CRC target database. The common gene names of target proteins were checked in Uniprot database. The STRING database was applied to analyze the interactions between the targets and the DAVID was used for the enrichment analysis on gene ontology (GO) biological process and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway. The network topology results were analyzed by Cytoscape 3.7.1 software.Results:134 active compounds of Sijunzi Decoction were gained, and PPI includes 125 targets protein (TP53,AKT1,IL-6,et al.). The 516 cellular biological processes, 53 cellular component and 98 molecular function were obtained through GO biological process enrichment analysis. The result of KEGG pathway enrichment showed that PI3K-Akt signaling pathway, TNF signaling pathway and FoxO signaling pathway were the main pathways.Conclusion:Sijunzi Decoction is mainly used to treat CRC by regulating key proteins such as TP53,AKT1, IL-6 and interfering with signal pathways such as PI3K-Akt, TNF and FoxO, reflecting the characteristics of Sijunzi Decoction in the treatment of CRC with multi-component,multi-target and multi-pathway characters.