Objective This study was aimed to explore the characteristic distribution of Post-COVID Conditions in cancer patients and observe the occurrence of Post-COVID Conditions after the intervention of Yinsang granules.Methods This study was a retrospective clinical observation,and a total of 1026 patients in Yang Yufei's outpatient department from January to February 2023 were screened,including 444 malignant tumor patients infected with COVID-19,among which 265 patients received intervention with Yinsang granules.The main observation indicator was the characteristic distribution of Post-COVID Conditions in malignant tumor patients,and the secondary observation indicator was the incidence of Post-COVID Conditions after intervention with Yinsang granules.Results A total of 444 patients with malignant tumors were included in this study,including 198 males(44.6％)and 246 females(55.4％).Average age 59.95±12.45;The five symptoms with the highest frequency of Post-COVID Conditions were fatigue,cough,dyspnea,insomnia and palpitation.The incidence of Post-COVID Conditions was higher in females than in males,and the difference was statistically significant(P＜0.05).The average age of Post-COVID Conditions is higher than that of non-Post-COVID Conditions(62 vs 58),and the age difference between the two groups was statistically significant(P＜0.05).The risk of developing Post-COVID Conditions in breast cancer patients was 2.9 times higher than that in colon cancer patients(P＜0.05).Yinsang granule,female and gastric cancer were the protective factors for the Post-COVID Conditions(P＜0.05).The incidence of Post-COVID Conditions was lower in the group taking Yinsang granule than in the group not taking it,and the difference was statistically significant between the two groups(P＜0.05).Conclusion Yinsang Granule intervention can reduce the incidence of Post-COVID Conditions in tumor patients.

Objective This study was aimed to explore the characteristic distribution of Post-COVID Conditions in cancer patients and observe the occurrence of Post-COVID Conditions after the intervention of Yinsang granules.Methods This study was a retrospective clinical observation,and a total of 1026 patients in Yang Yufei's outpatient department from January to February 2023 were screened,including 444 malignant tumor patients infected with COVID-19,among which 265 patients received intervention with Yinsang granules.The main observation indicator was the characteristic distribution of Post-COVID Conditions in malignant tumor patients,and the secondary observation indicator was the incidence of Post-COVID Conditions after intervention with Yinsang granules.Results A total of 444 patients with malignant tumors were included in this study,including 198 males(44.6％)and 246 females(55.4％).Average age 59.95±12.45;The five symptoms with the highest frequency of Post-COVID Conditions were fatigue,cough,dyspnea,insomnia and palpitation.The incidence of Post-COVID Conditions was higher in females than in males,and the difference was statistically significant(P＜0.05).The average age of Post-COVID Conditions is higher than that of non-Post-COVID Conditions(62 vs 58),and the age difference between the two groups was statistically significant(P＜0.05).The risk of developing Post-COVID Conditions in breast cancer patients was 2.9 times higher than that in colon cancer patients(P＜0.05).Yinsang granule,female and gastric cancer were the protective factors for the Post-COVID Conditions(P＜0.05).The incidence of Post-COVID Conditions was lower in the group taking Yinsang granule than in the group not taking it,and the difference was statistically significant between the two groups(P＜0.05).Conclusion Yinsang Granule intervention can reduce the incidence of Post-COVID Conditions in tumor patients.

Objective:To explore and evaluate the effect of clinical toxicity nursing on the therapeutic effect of paclitaxel combined with cisplatin in the treatment of recurrent cervical cancer.Methods:Sixty patients with recurrent cervical cancer treated in the Second Hospital of Tianjin Medical University from May 2017 to May 2019 were randomly divided into two groups. The control group was given paclitaxel chemotherapy and routine nursing, and the study group was given paclitaxel combined with cisplatin and clinical toxicity nursing.Results:In the study group, the total effective rate of 93.3% was significantly higher than that of 73.3% in the control group ( P<0.05), and the levels of inflammatory indexes, including C-reactive protein (CRP), interleukin-6 (IL-6), white blood cell (WBC) and erythrocyte sedimentation rate (ESR) in the study group were lower than those in the control group ( P<0.05). The incidence of toxicity in the study group was 10.0% lower than that in the control group(36.7%, P<0.05). Conclusions:The use of paclitaxel combined with cisplatin chemotherapy for recurrent cervical cancer and clinical toxic reaction nursing can improve the effectiveness rate of treatment, reduce the levels of various inflammatory indicators, and reduce the incidence of toxic reactions with high safety, thus prolonging the survival time of patients, making it worthy of clinical application.

Objective:To evaluate the clinical efficacy and influence factors of direct pulp capping using a bioactive ceramic in mature permanent teeth with carious pulp exposure, in order to explore the feasibility and indications of vital pulp therapy for such teeth.Methods:From January 2016 to September 2017, 57 patients (57 teeth) with carious pulp exposure in mature permanent teeth were selected from the Department of Cariology and Endodontology, Peking University School and Hospital of Stomatology. All the teeth were preoperatively diagnosed as deep caries with normal pulp or reversible pulpitis. After rubber dam isolation, all the carious dentin was removed and the exposed pulp tissue was observed under microscope. Hemostasis should be achieved within 3 min by using 2.5% sodium hypochlorite cotton pellets with a gently press. A resin composite restoration was performed immediately or 2 weeks later after direct pulp capping by using a bioceramic material (iRoot BP Plus). The patients were re-examined 12 to 50 months after operation (average 30 months) and the outcomes were evaluated by symptoms, clinical examination and X-ray. Kaplan-Meier survival analysis was used to calculate the success rate and influence factors were analyzed by Log-Rank test.Results:Totally 50 patients [age (32±13) years old (13-68 years old), 12 males and 38 females] received the follow-up examination more than one year. The overall success rate was 90% (45/50) and the success rates at 1 year, 2 years, 3 years and more were 98%, 89% and 81%, respectively. Age, gender, symptom, tooth and cavity type, pulpal exposure size and coronal restoration material had no significant correlations with the treatment outcome ( P>0.05). Conclusions:Direct pulp capping of mature permanent teeth with carious pulp exposure by using iRoot BP Plus might have high success rate. There′s no significant correlations between the major clinical factors and the treatment outcome.

OBJECTIVE： To systematically evaluate the efficacy and safety of Tapentadol immediate-release preparation （Tap IR） for relieving severe acute pain after brachiocephalic arteritis， and to provide evidence-based reference for rational drug use. METHODS： Retrieved from PubMed， Medline， Cochrane library， CNKI， VIP， Wanfang database and American clinical trial database， randomized controlled trials （RCTs） about Tap IR （trial group） versus Oxycodone immediate-release preparation or placebo for relieving severe acute pain after brachiocephalic arteritis were collected. After literature screening， data extraction and literature quality evaluation with modified Jadad scale， Meta-analysis was conducted by using RevMan 5.3 software. RESULTS： A total of 6 RCTs were included， involving 2 378 patients. Results of Meta-analysis showed that 48 h total pain relief value （TOTPAR48） of trial group was significantly higher than control group [MD＝35.60，95％CI（27.31， 43.88）， P＜0.000 01]. Results of sub-group analysis showed that TOTPAR48 of trial group using Tap IR 50 mg [MD＝28.68， 95％CI （18.18， 39.17），P＜0.00 001]， 75 mg [MD＝39.97， 95％CI （34.21， 45.73）， P＜0.000 01] and 100 mg[MD＝38.50， 95％CI（1.46， 75.54），P＝0.04] were significantly higher than control group； TOTPAR48 of patients who received Tap IR 75 mg were significantly higher than patients who received Tap IR 50 mg [MD＝9.04，95％ CI（4.31， 13.77），P＝0.000 2]. There was no statistical significance in the utilization rate of rescue medicine （URM） between 2 groups [RR＝1.23，95％ CI（0.84， 1.80），P＝0.29]. Subgroup analysis showed that URM in patients who received Tap IR 75 mg was significantly lower than those receiving Tap IR 50 mg [RR＝0.62，95％CI（0.41， 0.94），P＝0.02]. The total difference of 48 h pain intensity （SPID48） in trial group was significantly lower than control group [MD＝－18.96，95％CI（－37.28，－0.64），P＝0.04]. Subgroup analysis showed that SPID48 in patients who received Tap IR 75 mg was significantly higher than those receiving Tap IR 50 mg [MD＝21.66，95％CI（8.93， 34.39），P＝0.000 9]. There was no statistical significance in the total change of pain impression （PGIC） between 2 groups [RR＝0.95，95％CI（0.88， 1.03），P＝0.23]. Subgroup analysis showed that PGIC in patients who received Tap IR 75 mg was significantly higher than those receiving Tap IR 50 mg [RR＝1.07，95％CI（1.01， 1.13），P＝0.02] but significantly lower than those receiving Tap IR 100 mg [RR＝0.86，95％CI（0.77， 0.97），P＝0.01]. The incidence of nausea， vomiting， constipation， dizziness and headache in trial group were significantly lower than control group （P＜0.05）. CONCLUSIONS： Tap IR shows good therapeutic efficacy and safety for severe acute pain after brachiocephalic arteritis， and the efficacy of Tap IR might be better when the dose of Tap IR is 75 mg.

Objective To investigate the features of negative automatic thinking among military personnel stationed on the island and also to analyze related influencial factors.Methods Assessment was performed among the military personnel stationed on the island and ashore by using automatic thinking scale,perceived social support scale and social stress scale,then,the relationship between negative automatic thinking and perceived social support and psychological stress was analyzed in the study.Results The detection rates of automatic thinking,perceived social support and psychological stress among the military personnel stationed on the island were all obviously higher than those of the military personnel working ashore.(P ＜ 0.05 or P ＜ 0.01).The total scores of automatic thinking and stress in the military personnel working on the island were all higher than those of the people working ashore (P ＜ 0.05).There were significant differences in total scores of various scales,when comparisons were made between commissioned officers of the 2 groups (P ＜ 0.05).Differences could only be seen in external family support and stress scores among commissioned officers.Total scores of internal family support and perceived social support of commissioned officers were all lower than those of the non-commissioned officers,but the scores of automatic thinking were higher than those of the non-commissioned officers (P ＜ 0.05).Pearson analysis showed that negative automatic thinking was positively correlated with psychological stress (r =0.292,P ＜ 0.05),however the scores of perceived social support were negatively correlated with the scores of various dimensions (r =-0.540 -0.672,P ＜ 0.05).Stepwise regression analysis indicated that perceived social support partially mediated the relationship between psychological stress and negative automatic thinking,and the mediating effect accounted for 30.9％ of the total effect.Conclusion Negative automatic thinking among the military personnel stationed on the island was on the whole not optimistic,and its influential factors included psychological stress and low social support.Psychological stress could affect negative automatic thinking of the military personnel stationed on the island directly or indirectly by mediating effect.Active and effective family and social support,rational psychological counseling and training were beneficial to the alleviation of negative thinking and the improvement of the physical and mental health of the military personnel stationed on the island.

Objective To investigate the features of negative automatic thinking among military personnel stationed on the island and also to analyze related influencial factors.Methods Assessment was performed among the military personnel stationed on the island and ashore by using automatic thinking scale,perceived social support scale and social stress scale,then,the relationship between negative automatic thinking and perceived social support and psychological stress was analyzed in the study.Results The detection rates of automatic thinking,perceived social support and psychological stress among the military personnel stationed on the island were all obviously higher than those of the military personnel working ashore.(P ＜ 0.05 or P ＜ 0.01).The total scores of automatic thinking and stress in the military personnel working on the island were all higher than those of the people working ashore (P ＜ 0.05).There were significant differences in total scores of various scales,when comparisons were made between commissioned officers of the 2 groups (P ＜ 0.05).Differences could only be seen in external family support and stress scores among commissioned officers.Total scores of internal family support and perceived social support of commissioned officers were all lower than those of the non-commissioned officers,but the scores of automatic thinking were higher than those of the non-commissioned officers (P ＜ 0.05).Pearson analysis showed that negative automatic thinking was positively correlated with psychological stress (r =0.292,P ＜ 0.05),however the scores of perceived social support were negatively correlated with the scores of various dimensions (r =-0.540 -0.672,P ＜ 0.05).Stepwise regression analysis indicated that perceived social support partially mediated the relationship between psychological stress and negative automatic thinking,and the mediating effect accounted for 30.9％ of the total effect.Conclusion Negative automatic thinking among the military personnel stationed on the island was on the whole not optimistic,and its influential factors included psychological stress and low social support.Psychological stress could affect negative automatic thinking of the military personnel stationed on the island directly or indirectly by mediating effect.Active and effective family and social support,rational psychological counseling and training were beneficial to the alleviation of negative thinking and the improvement of the physical and mental health of the military personnel stationed on the island.

Objective To explore the effects of C/EBPα knockout in podocyte on diabetic nephropathy and its mechanisms.Methods C/EBPαloxp/loxp mice were crossed with podocin-cre mice to obtain F1 hybrids and then propagated until homozygous mice (C/EBPαf/f) were obtained.Diabetic nephropathy (DN) models were established by low-dose streptozotocin (STZ,100 mg/kg) administration after 25 weeks of normal diet or 45％ high-fat diet treatment,and biochemical indicators of blood and urea were measured.The morphological characteristics and the proteins regulating oxidative stress and mitochondrial function were detected.Results The type 2 DN models were successfully constructed based on transgenic mice.The kidneys of 8-month-old C/EBPαf/f mice did not show obvious morphological changes,but after constructing DN models,they showed obvious renal impairment,inflammation and oxidative stress.Compared with wild-type DN mice,the protein levels of nephrin and E-cadherin in DN C/EBPαf/f mice with DN were significantly decreased (P ＜ 0.01);fibronectin and Nrf2 protein levels were all increased (all P ＜ 0.05).Keap1,phospho-AMPK and mitochondrial function related genes Pgc-1α protein levels were all decreased (all P ＜ 0.05).Conclusion Podocyte C/EBPα knockout exacerbates diabetic nephropathy by promoting fibrosis and inhibiting Pgc-1α-mediated mitochondrial antioxidant function.