Neuropathic pain (NP) is a common complication following spinal cord injury, with an incidence rate ranging from 38% to 70%. NP typically presents as sensation of burning, electric shocks, tingling or squeezing pain resulting from somatosensory nerve damage, which exerts a negative impact on patients′ physical and psychological well-being. After spinal cord injury, glial cells are activated to induce inflammatory cascade. Accordingly, various inflammatory mediators that may disrupt the neuronal function are released to promote abnormally increased neuronal excitability and pain signal transduction. Additionally, spinal cord injury can disrupt the release of neurotransmitters and neurotrophic factors, alter ion channel activity, and thereby impair the normal pain regulatory mechanisms and further increase pain perception. The interaction of these mechanisms contributes to the occurrence and persistence of NP after spinal cord injury. However, the precise pathogenesis of NP remains incompletely elucidated, making its therapeutic efficacy uncertain and clinical management difficult. It is of great significance to thoroughly understand the underlying pathophysiological mechanisms of NP following spinal cord injury for its treatment. For this reason, the authors reviewed the research progress on the characteristics and pathophysiological mechanisms of NP following spinal cord injury, aiming to serve as a reference for further research and development of more effective targeted therapies and management strategies.

Non-exosomal non-coding RNAs (non-exo-ncRNAs) and exosomal ncRNAs (exo-ncRNAs) have been associated with the pathological development of myocardial infarction (MI). Accordingly, this analytical review provides an overview of current MI studies on the role of plasma non-exo/exo-ncRNAs. We summarize the features and crucial roles of ncRNAs and reveal their novel biological correlations via bioinformatics analysis. The following contributions are made: (1) we comprehensively describe the expression profile, competing endogenous RNA (ceRNA) network, and "pre-necrotic" biomarkers of non-exo/exo-ncRNAs for MI; (2) functional enrichment analysis indicates that the target genes of ncRNAs are enriched in the regulation of apoptotic signaling pathway and cellular response to chemical stress, etc.; (3) we propose an updated and comprehensive view on the mechanisms, pathophysiology, and biomarker roles of non-exo/exo-ncRNAs in MI, thereby providing a theoretical basis for the clinical management of MI.
Humans ; RNA, Untranslated/genetics* ; RNA ; Myocardial Infarction/genetics* ; Biomarkers ; Computational Biology ; MicroRNAs/genetics*

OBJECTIVE To explore the pharmaceutical service model in multidisciplinary diagnosis and treatment （MDT） of rare diseases in children. METHODS Clinical pharmacists of West China Second University Hospital （hereinafter referred to as “our hospital”） participated in the process of MDT of children’s rare diseases. Clinical pharmacists took part in the entire diagnosis and treatment process of children and established the MDT pharmaceutical service model of children’s rare diseases by formulating drug treatment plans based on evidence-based practice， improving the accessibility of drugs， pharmaceutical monitoring and drug treatment management. RESULTS From January 2021 to April 2022， clinical pharmacists of our hospital had participated in a total of 39 cases of rare diseases MDT in children， including 21 hospitalized children with rare diseases and 18 outpatient com children with rare diseases， involving a total of 23 rare diseases. Clinical pharmacists completed 45 pharmaceutical zhanglingli@scu.edu.cn rounds and 26 pharmaceutical consultations for rare diseases inpatients， 25 outpatients’ MDT and 5 pharmaceutical outpatient service for outpatients with rare diseases， 38 medication educations for inpatients and outpatients with rare diseases and 25 follow-up services for out-of-hospital patients. There were 24 cases （61.54%） of off-label drug use， involving 13 rare diseases and 16 therapeutic drugs， among which off-label drug use registration of 11 drugs had been completed or was in progress. The temporary purchase evaluations of 3 drugs had been completed； 268 cases of medical insurance drug and high-value drug prescription had been reviewed. CONCLUSIONS Our hospital have primarily established a loop pharmaceutical service model of MDT for children with rare diseases， which covers inpatients and outpatients. The model improves the availability and standardization of clinical application of therapeutic drugs， and diagnosis and treatment level for children with rare diseases in our hospital.

Female genital plastic surgery usually includes labiaplasty, labia majora augmentation, and vaginoplasty. There are two possible reasons for patients to seek such operations: functional and aesthetic. This article summarizes and comments on these operations and points out that plastic surgeons need to select appropriate surgical indications, prevent and treat possible complications. At the same time, the wishes of patients should be respected.

Female genital plastic surgery usually includes labiaplasty, labia majora augmentation, and vaginoplasty. There are two possible reasons for patients to seek such operations: functional and aesthetic. This article summarizes and comments on these operations and points out that plastic surgeons need to select appropriate surgical indications, prevent and treat possible complications. At the same time, the wishes of patients should be respected.

Objective:To compare the pros and cons of harvesting ear cartilage through anterior and posterior auricular approaches during rhinoplasty.Methods:From January 2017 to December 2018, 63 patients with otochondral rhinoplasty in our hospital were enrolled in this study, 60 were female and 3 were male; the average age was 31.6 years (range, 18 to 43) . They were randomly divided into anterior auricular approach group with 32 cases (64 sides) and posterior auricular approach group with 31 cases (62 sides). Surgical duration, complications and postoperative scar of the two methods were analyzed.Results:The average time for harvesting the ear cartilage through posterior auricular approach and anterior auricular approach was (20.8±1.7) min and (12.6±1.1) min, respectively ( P<0.01). The overall complication rate was 15.6% for posterior auricular approach group and 4.8% for anterior auricular approach group. The wound healed well in both groups, and there was no significant difference in postoperative scar between the two groups during an average 13 months follow-up period. Conclusions:While both the anterior and the posterior auricular approaches present with similar inconspicuous scarring, the use of anterior auricular approach alone to harvest ear cartilage during rhinoplasty provides both the surgeons and the patients with easier access, shorter surgical duration, and fewer complications. Hence, we believe that the anterior auricular approach possesses greater advantages than the posterior auricular approach.

Female genital plastic surgery usually includes labiaplasty, labia majora augmentation, and vaginoplasty. There are two possible reasons for patients to seek such operations: functional and aesthetic. This article summarizes and comments on these operations and points out that plastic surgeons need to select appropriate surgical indications, prevent and treat possible complications. At the same time, the wishes of patients should be respected.

Female genital plastic surgery usually includes labiaplasty, labia majora augmentation, and vaginoplasty. There are two possible reasons for patients to seek such operations: functional and aesthetic. This article summarizes and comments on these operations and points out that plastic surgeons need to select appropriate surgical indications, prevent and treat possible complications. At the same time, the wishes of patients should be respected.

Objective:To investigate the therapeutic effects of tendon acupuncture combined with hyperbaric oxygen (HBO) in treating rotator cuff injury.Methods:A total of 68 patients with rotator cuff injury treated in Qingdao Recuperation Center for PLA Naval Specialized Services from June 2019 to June 2020 were divided into observation group ( n=34) and control group ( n=34) by the random number table method. The control group was given conventional tendon acupuncture, while the observation group was given both tendon acupuncture and HBO treatment. Both groups received four weeks of treatment. The visual analogue score (VAS) was used to assess the pain severity in the control group and the observation group before and after treatment; the wireless joint mobility tester was used to measure the shoulder mobility and assess the change of the range of motion (ROM) before and after treatment. After treatment, the VAS in the observation group was lower than those in the control group, and the difference was statistically significant ( P<0.05). Results:After treatment, the mobilities of internal rotation, external rotation, abduction, posterior extension, and forward flexion of the shoulder joint in the observation group were significantly higher than those in the control group, and the differences were statistically significant ( P<0.05). Conclusion:Tendon acupuncture combined with HBO therapy is effective in treating shoulder joint injury and is worth wide application in clinical practice.

Objective:To investigate the therapeutic effects of tendon acupuncture combined with hyperbaric oxygen (HBO) in treating rotator cuff injury.Methods:A total of 68 patients with rotator cuff injury treated in Qingdao Recuperation Center for PLA Naval Specialized Services from June 2019 to June 2020 were divided into observation group ( n=34) and control group ( n=34) by the random number table method. The control group was given conventional tendon acupuncture, while the observation group was given both tendon acupuncture and HBO treatment. Both groups received four weeks of treatment. The visual analogue score (VAS) was used to assess the pain severity in the control group and the observation group before and after treatment; the wireless joint mobility tester was used to measure the shoulder mobility and assess the change of the range of motion (ROM) before and after treatment. After treatment, the VAS in the observation group was lower than those in the control group, and the difference was statistically significant ( P<0.05). Results:After treatment, the mobilities of internal rotation, external rotation, abduction, posterior extension, and forward flexion of the shoulder joint in the observation group were significantly higher than those in the control group, and the differences were statistically significant ( P<0.05). Conclusion:Tendon acupuncture combined with HBO therapy is effective in treating shoulder joint injury and is worth wide application in clinical practice.