Objective:To establish and verify a nomogram model for predicting the risk of non-alcoholic fatty liver disease (NAFLD) in helicopter flying personnel.Methods:The helicopter flying personnel who recuperated at Air Force Healthcare Center for Special Services Hangzhou were selected as the study subjects. They were divided into the training group (75%) and the verification group (25%) by using the cluster random sampling method for internal verification. Multivariate Logistic regression analysis was used to analyze the factors influencing NAFLD of helicopter flying personnel, and the nomogram model was constructed by R4.2.1 software and rms package. The H-L goodness-of-fit test and receiver operating characteristic (ROC) curve were used to assess the discrimination and calibration of the prediction model, and decision curve analysis (DCA) was used to evaluate the clinical practicality of the model.Results:A total of 2 195 helicopter flying personnel were included, with 1 648 in the training group and 547 in the verification group. Seven variables, including age, BMI, hyperuricemia, hypertriglyceridemia, abnormal high-density lipoprotein, daily intakes of milk and/or its products and years of smoking were used as the predictors of the nomogram model for the risk prediction of NAFLD in helicopter flying personnel. The H-L goodness-of-fit tests of training group and verification group were χ2=8.54, 11.03, P=0.382, 0.200, respectively, indicating a good predictive accuracy. The area under the ROC curve of the 2 groups was 0.840 and 0.860, respectively, indicating a certain degree of discrimination. The incidence risk probability of DCA curve in 2 groups was about 10%-30%, and the net return rate was above 0, suggesting that it had a certain clinical applicability. Increased age ( OR=1.18, P=0.010), overweight and obesity ( OR=3.67, P<0.001), hyperuricemia ( OR=2.12, P<0.001), hypertriglyceridemia ( OR=2.96, P<0.001), abnormal high-density lipoprotein cholesterol ( OR=1.83, P=0.010), and increased years of smoking ( OR=1.20, P=0.010) were the risk factors for NAFLD in helicopter flying personnel, while increased daily intakes of milk and/or its products ( OR=0.76, P=0.020) were identified as a protective factor. Conclusions:The nomogram model based on the aforementioned factors can effectively evaluate the incidence risk of NAFLD in helicopter flying personnel, and has certain clinical practicality.

Objective:To establish and verify a nomogram model for predicting the risk of non-alcoholic fatty liver disease (NAFLD) in helicopter flying personnel.Methods:The helicopter flying personnel who recuperated at Air Force Healthcare Center for Special Services Hangzhou were selected as the study subjects. They were divided into the training group (75%) and the verification group (25%) by using the cluster random sampling method for internal verification. Multivariate Logistic regression analysis was used to analyze the factors influencing NAFLD of helicopter flying personnel, and the nomogram model was constructed by R4.2.1 software and rms package. The H-L goodness-of-fit test and receiver operating characteristic (ROC) curve were used to assess the discrimination and calibration of the prediction model, and decision curve analysis (DCA) was used to evaluate the clinical practicality of the model.Results:A total of 2 195 helicopter flying personnel were included, with 1 648 in the training group and 547 in the verification group. Seven variables, including age, BMI, hyperuricemia, hypertriglyceridemia, abnormal high-density lipoprotein, daily intakes of milk and/or its products and years of smoking were used as the predictors of the nomogram model for the risk prediction of NAFLD in helicopter flying personnel. The H-L goodness-of-fit tests of training group and verification group were χ2=8.54, 11.03, P=0.382, 0.200, respectively, indicating a good predictive accuracy. The area under the ROC curve of the 2 groups was 0.840 and 0.860, respectively, indicating a certain degree of discrimination. The incidence risk probability of DCA curve in 2 groups was about 10%-30%, and the net return rate was above 0, suggesting that it had a certain clinical applicability. Increased age ( OR=1.18, P=0.010), overweight and obesity ( OR=3.67, P<0.001), hyperuricemia ( OR=2.12, P<0.001), hypertriglyceridemia ( OR=2.96, P<0.001), abnormal high-density lipoprotein cholesterol ( OR=1.83, P=0.010), and increased years of smoking ( OR=1.20, P=0.010) were the risk factors for NAFLD in helicopter flying personnel, while increased daily intakes of milk and/or its products ( OR=0.76, P=0.020) were identified as a protective factor. Conclusions:The nomogram model based on the aforementioned factors can effectively evaluate the incidence risk of NAFLD in helicopter flying personnel, and has certain clinical practicality.

Objective:To comprehensively collect the clinical research evidence of Wuqinxi, and provide reference for the future clinical research.Methods:China National Knowledge Infrastructure (CNKI), WanFang Database, VIP, China Biology Medicine disc (CBM), PubMed, Embase, Cochrane Library, and Web of Science were searched. The retrieval time limit was from the establishment of each database to March 31, 2021. After screening and extracting, SPSS 22.0 was used to analyze the basic characteristics, sample size, control and intervention measures, outcomes.Results:Totally 230 studies were included, of which 58.26% (134/230) were randomized controlled trial. The top 6 diseases were chronic obstructive pulmonary disease, osteoporosis, cervical pain, low back pain, diabetes and knee osteoarthritis. Common outcome included four items of blood lipid tests, blood glucose, immunological indicators and the evaluation of disease-related symptoms, such as pain, sleep and range of motion. The median frequency of Wuqinxi was once a day, 45 minutes each time, 5 days a week and lasted for 3 months. 94.78% (218/230) of the studies reported positive results. The safety and compliance of Wuqinxi intervention were good.Conclusions:The number of clinical studies on Wuqinxi is significantly less than Baduanjin and Taijiquan. It is necessary to formulate the report specification of intervention measures for Wuqinxi, so as to report the intervention plan of Wuqinxi more clearly and transparently.

Objective:To carry out content analysis of clinical practice guideline recommendations related to physical activity in survivors of colorectal cancer at home and abroad so as to provide a reference for formulating a standardized and personalized physical activity plan for survivors of colorectal cancer.Methods:Clinical practice guidelines related to physical activity in survivors of colorectal cancer were retrieved in Chinese-English databases, guideline websites and professional society websites by computer from 1st, January 2009 to 1st, July 2019. Guideline recommendations were extracted, translated, classified and analyzed on content with the method of content analysis.Results:A total of 7 clinical practice guidelines were included and 26 recommendations on physical activity of survivors of colorectal cancer were extracted. A total of 8-item content on physical activity were analyzed including the safety and benefits of physical activity, assessment before physical activity, amount of physical activity, way of physical activity, intensity, frequency and duration of physical activity, attention of physical activity, contraindications of physical activity and incremental strategy of physical activity.Conclusions:There are many recommendations on the way, amount, frequency, intensity and attention of physical activity. There are inconsistencies between recommendation mentioned frequency and clinical importance, and consistencies between partial recommendations and domestic practice content, and the recom mendations are more diversified than domestic practice content. We should carry out localization for the high level of foreign guideline to explore the evidences suitable for physical activity in survivors of colorectal cancer in China.

The elderly group is a special group of people. More and more studies have found that the related diseases of the elderly may be closely related to the age of intestine. The microbiota in the intestinal microecology participates in body's defense, immunity, nutrition, metabolism, cancer suppression as well as anti-aging. Once age-related diseases occur, the stability and abundance of intestinal microbiota is bound to be disturbed. This article reviews the relationship between intestinal microbiota and age-related diseases so as to provide new ideas and directions for the treatment and nursing care of elderly diseases.