Da Chaihutang， first recorded in Shanghanlun by Zhang Zhongjing of the Eastern Han dynasty， is composed of eight medicinal herbs， namely Bupleuri Radix， Scutellariae Radix， Rhei Radix et Rhizoma， Aurantii Fructus Immaturus， Paeoniae Radix Alba， Pinelliae Rhizoma， Zingiberis Rhizoma Recens， and Jujubae Fructus. It features a well-defined hierarchy of sovereign， minister， assistant， and courier ingredients. The prescription is characterized by its balanced compatibility， mutually restrained cold and warm properties， and combined use of harmonizing and purging therapeutic strategies. As a renowned classical formula indicated for harmonizing Shaoyang and purging internal heat accumulation， it is the core prescription for the treatment of Shaoyang-Yangming combined disease. A comprehensive review of modern research literature on Da Chaihutang reveals that its chemical composition is notably diverse. The core pharmacologically active material bases of its constituent single herbs have been clearly identified， including saikosaponins from Bupleuri Radix， flavonoids from Scutellariae Radix， anthraquinones from Rhei Radix et Rhizoma， flavonoids and alkaloids from Aurantii Fructus Immaturus， monoterpene glycosides from Paeoniae Radix Alba， alkaloids and organic acids from Pinelliae Rhizoma， gingerols from Zingiberis Rhizoma Recens， and polysaccharides and triterpenoid acids from Jujubae Fructus. In the compound formula， a total of 163 chemical constituents have been comprehensively identified， among which flavonoids and their glycosides constitute the most abundant component category. Flavonoids and their glycosides， monoterpene glycosides， and pentacyclic triterpenoid saponins are regarded as the core pharmacologically active substances of the whole formula. In addition， 9 potential quality markers that can comprehensively characterize the overall quality and core therapeutic efficacy of the whole formula have been screened out. Modern pharmacological studies have shown that the pharmacological effects of Da Chaihutang exhibit synergistic characteristics involving multiple components， multiple targets， and multiple pathways. Its core pharmacological activities encompass the regulation of digestive system disorders， including pancreatic protection， intervention in biliary tract diseases， and protection of gastrointestinal mucosa； intervention in hepatobiliary diseases such as non-alcoholic fatty liver disease and cholestatic liver injury； and regulation of metabolic disorders such as hypoglycemic effect， improvement of insulin resistance， and regulation of lipid metabolism. Furthermore， it also possesses multiple pharmacological activities， including intervention in atherosclerosis， regulation of immune and inflammatory responses， multi-organ protection， and anti-hepatocellular carcinoma effect. In modern clinical practice， Da Chaihutang and its modified formulas are mostly used in combination with conventional Western medical regimens. They have demonstrated notable therapeutic advantages in the treatment of digestive system diseases such as cholecystitis， acute pancreatitis， cholelithiasis， and non-alcoholic fatty liver disease， but also have shown definite curative efficacy in the management of diseases affecting multiple other systems， including cardiovascular， endocrine， dermatological， reproductive， respiratory， neurological， urinary， pediatric， and immune systems. These combined applications can effectively improve the overall clinical response rate， shorten the time to symptom relief， and reduce both the disease recurrence rate and the incidence of adverse reactions. This review systematically summarized the formula compatibility， chemical constituents， pharmacological mechanisms， and modern clinical applications of Da Chaihutang and its modified formulas， to provide a theoretical basis and practical reference for the secondary development of classic formulas， the research and development of new drugs， and the precise and safe clinical application of this classical prescription.

The acquired immune deficiency syndrome(AIDS)-induced fever is mainly characterized by long-term,recurrent and irregular symptom,which poses a major threat to the quality of life of the AIDS patients.Tradition-al Chinese Medicine(TCM)has offered an approach of treatment determination based on syndrome differentiation and formula corresponding to syndrome on basis of the idea of'same disease,different therapies'.The earliest or-igin of the idea of'same disease,different therapies' can be traced back to'Huang Di Nei Jing',it plays a signifi-cant role in the theory of TCM after continuous enrichment and development by ancient medical families.The indi-vidualized therapeutic regimen is formulated based on the etiology,pathogenesis and physical condition(such as qi-insufficiency constitution,phlegm-dampness constitution),emphasizing the vital role of'treatment determina-tion based on syndrome differentiation'in the treatment process,highlighting the importance of personnel experi-ence of doctors,and showing the precise effect of TCM on treatment of AIDS-induced fever.

The acquired immune deficiency syndrome(AIDS)-induced fever is mainly characterized by long-term,recurrent and irregular symptom,which poses a major threat to the quality of life of the AIDS patients.Tradition-al Chinese Medicine(TCM)has offered an approach of treatment determination based on syndrome differentiation and formula corresponding to syndrome on basis of the idea of'same disease,different therapies'.The earliest or-igin of the idea of'same disease,different therapies' can be traced back to'Huang Di Nei Jing',it plays a signifi-cant role in the theory of TCM after continuous enrichment and development by ancient medical families.The indi-vidualized therapeutic regimen is formulated based on the etiology,pathogenesis and physical condition(such as qi-insufficiency constitution,phlegm-dampness constitution),emphasizing the vital role of'treatment determina-tion based on syndrome differentiation'in the treatment process,highlighting the importance of personnel experi-ence of doctors,and showing the precise effect of TCM on treatment of AIDS-induced fever.