Endometriosis (EMS) is one of the most common clinical gynecological diseases, which mainly causes dysmenorrhea, chronic pelvic pain and infertility. The incidence of EMS in women of childbearing age is as high as 10%, which brings great harm to women's physical and mental health. There are many theories about the pathogenesis of EMS. So far, no single hypothesis can fully explain its occurrence. Numerous studies have demonstrated chronic inflammatory reactions in the peritoneal cavity of patients with EMS, and multiple immune cells and cytokines are involved in this process. Therefore, the role of immune factors in the occurrence and development of EMS has become the focus of recent research. Neutrophils, as the main participants in the process of inflammatory response, have received wide attention in the study of endometriosis. This paper reviews the research progress on neutrophils in EMS.

Endometriosis (EMS) is one of the most common clinical gynecological diseases, which mainly causes dysmenorrhea, chronic pelvic pain and infertility. The incidence of EMS in women of childbearing age is as high as 10%, which brings great harm to women's physical and mental health. There are many theories about the pathogenesis of EMS. So far, no single hypothesis can fully explain its occurrence. Numerous studies have demonstrated chronic inflammatory reactions in the peritoneal cavity of patients with EMS, and multiple immune cells and cytokines are involved in this process. Therefore, the role of immune factors in the occurrence and development of EMS has become the focus of recent research. Neutrophils, as the main participants in the process of inflammatory response, have received wide attention in the study of endometriosis. This paper reviews the research progress on neutrophils in EMS.

Objective To investigate whether the effect of transient high glucose on inflammatory factors expression could be continuous in rat glomerular mesangial cell,and its relation with histone methylation modification.Methods Rat glomerular mesangial cells (HBZY-l) were divided into three groups:the high glucose group (25.0 mmol/L glucose),the hypertonic group (MA,5.5 mmol/L glucose+ 19.5 mmol/L mannitol) and the normal-glucose control group (5.5 mmol/L glucose),which were cultured for 24 h respectively.All 3 groups were then changed with normal-glucose medium to culture for 24 h,48 h and 72 h.Their protein,mRNA and supernatant were harvested.The protein expressions of mono-methylation of H3 lysine 4 (H3K4mel) was measured by Western blotting,and the mRNA expressions of NF-κB subunit p65 and set7/9 were determined by real timequantitative PCR.The expression of monocyte chemoattractant protein 1 (MCP-1) and vascular cell adhesion molecule 1 (VCAM-1) were detected by enzyme-linked immunosorbent assay.Results (1)Compared with those in normal control group,the expressions of H3K4mel protein and set7/9 mRNA were first up-regulated in high glucose group,then gradually down-regulated in the following 48 h normal-glucose medium (as compared with those at 0 h,all P ＜ 0.05).At 72 h there was no statistic difference between high glucose group and normal control group (all P ＞ 0.05).(2) Compared with those in normal control group,the up-regulated p65 mRNA,VCAM-1 and MCP-1 sustained at least for 72 h in high glucose group.Conclusions Transient high glucose can induce persistent inflammatory factors expression in rat glomerular mesangial cells,which may via histone modification.

The three-dimensional facial wrinkle measurement and quantification have important applications in many fields, which are implemented by an entire system proposed in this paper. The system uses stereo vision method based on structured-light to achieve three-dimensional facial wrinkle measuring, where the system calibration, corresponding points matching and three-dimensional reverse method are implemented. Furthermore, the facial wrinkle is considered as the noise attached on smooth facial profi le so that the facial wrinkle is acquired quantitatively by three-dimensional noise acquisition and morphologic processing method. The experimental results show that this system can accomplish accurate facial wrinkle acquisition and objective quantifi cation. This system has comprehensive applications as it is non-contact and it has high precision.