1.Association between white matter hyperintensities and impaired dopaminergic system function in patients with PD
Wanlin LI ; Ai GUAN ; Xinyi XIE ; Yunlan DU ; Ruolian DAI ; Zhongjiao LU ; Gang CHEN ; Qing DONG ; Hualong WANG ; Gang WANG
Chinese Journal of Geriatric Heart Brain and Vessel Diseases 2025;27(10):1304-1308
Objective To analyze white matter hyperintensities(WMH)and 11C-CFT PET/CT characteristics in patients with PD,and explore their relationship.Methods A total of 84 PD pa-tients admitted to our department between March 2021 and March 2025 were retrospectively en-rolled,and they were divided into young group(33 cases)and elderly group(aged>65 years,51 cases)and also into non-WMH group(22 cases)and WMH group(62 cases)based on the severity of WMH.The degree of white matter lesions was scored,including periventricular white matter hyperintense(PVH)score and deep white matter hyperintense(DWMH)score.All patients un-derwent head MRI and 11C-CFT-PET/CT scanning.The T/N value and asymmetry index were calculated.Results The elderly PD patients exhibited significantly advanced age and higher H-Y stages,but lower T/N values of affected side of caudate nucleus,contralateral caudate nucleus,affected side of anterior putamen,contralateral anterior putamen and contralateral posterior puta-men,and posterior putamen asymmetry index than the young patients(P<0.05,P<0.01).Simi-lar results were observed in the WMH group when compared with the non-WMH group(P<0.05,P<0.01).The PVH score was negatively correlated with the T/N values of affected side of caudate nucleus(r=-0.282,P=0.009),contralateral caudate nucleus(r=-0.215,P=0.049),affected side of anterior putamen(r=-0.249,P=0.022),contralateral anterior putamen(r=-0.280,P=0.010)and contralateral posterior putamen(r=-0.285,P=0.009),and DWMH score was also negatively correlated with the T/N values in the affected side of caudate nucleus and affected side of anterior putamen(P<0.05).Conclusion Both age and disease severity impact WMH and dopaminergic system in PD patients.A higher WMH load is associated with dopamin-ergic neuronal damage.
2.Association between white matter hyperintensities and impaired dopaminergic system function in patients with PD
Wanlin LI ; Ai GUAN ; Xinyi XIE ; Yunlan DU ; Ruolian DAI ; Zhongjiao LU ; Gang CHEN ; Qing DONG ; Hualong WANG ; Gang WANG
Chinese Journal of Geriatric Heart Brain and Vessel Diseases 2025;27(10):1304-1308
Objective To analyze white matter hyperintensities(WMH)and 11C-CFT PET/CT characteristics in patients with PD,and explore their relationship.Methods A total of 84 PD pa-tients admitted to our department between March 2021 and March 2025 were retrospectively en-rolled,and they were divided into young group(33 cases)and elderly group(aged>65 years,51 cases)and also into non-WMH group(22 cases)and WMH group(62 cases)based on the severity of WMH.The degree of white matter lesions was scored,including periventricular white matter hyperintense(PVH)score and deep white matter hyperintense(DWMH)score.All patients un-derwent head MRI and 11C-CFT-PET/CT scanning.The T/N value and asymmetry index were calculated.Results The elderly PD patients exhibited significantly advanced age and higher H-Y stages,but lower T/N values of affected side of caudate nucleus,contralateral caudate nucleus,affected side of anterior putamen,contralateral anterior putamen and contralateral posterior puta-men,and posterior putamen asymmetry index than the young patients(P<0.05,P<0.01).Simi-lar results were observed in the WMH group when compared with the non-WMH group(P<0.05,P<0.01).The PVH score was negatively correlated with the T/N values of affected side of caudate nucleus(r=-0.282,P=0.009),contralateral caudate nucleus(r=-0.215,P=0.049),affected side of anterior putamen(r=-0.249,P=0.022),contralateral anterior putamen(r=-0.280,P=0.010)and contralateral posterior putamen(r=-0.285,P=0.009),and DWMH score was also negatively correlated with the T/N values in the affected side of caudate nucleus and affected side of anterior putamen(P<0.05).Conclusion Both age and disease severity impact WMH and dopaminergic system in PD patients.A higher WMH load is associated with dopamin-ergic neuronal damage.
3.Design and writing practice of standardized training cases for professional master students based on organ systems
Qing ZHOU ; Qiuhong JI ; Jianhong SHEN ; Dong TANG ; Yunlan JI ; Yuhua LU ; Wei SHI
Chinese Journal of Medical Education Research 2024;23(7):1004-1008
With reference to the teaching reform of standardized training cases based on organ systems, a teaching case writing team has been established, integrating the teaching experts in basic medicine, clinical medicine, humanities medicine, and other fields. Through collective lesson preparation and discussion, non-fictional comprehensive scenario writing techniques have been used based on organ systems and oriented by competency development, and the teaching cases for postgraduate students were written on the basis of real cases, which lays a solid foundation for the hierarchical and progressive cultivation and improvement of the quality of competency cultivation for postgraduate students through case teaching based on organ systems.
4.Application of hierarchical and progressive teaching in standardized residency training: difficulties and countermeasures
Qing ZHOU ; Dong TANG ; Yunlan JI ; Qiuhong JI ; Yunyun WANG ; Wei SHI ; Yuhua LU
Chinese Journal of Medical Education Research 2024;23(8):1118-1122
By identifying and analyzing the problems and difficulties in the implementation process of student stratification, goal stratification, practice stratification, and assessment stratification in standardized residency training, this article proposes to fully leverage the main role of professional bases in hierarchical and progressive teaching for standardized residency training and strengthen the specific responsibilities of professional base teaching groups in discussing hierarchical and progressive teaching plans, evaluation standards, and assessments. It is also necessary to scientifically implement student stratification, achieve consistent stratification goals, strengthen the training of hierarchical and progressive teaching concepts and teaching abilities for teachers, enhance the ability for homogeneous and hierarchical evaluation, and develop countermeasures that combine stage training goal process evaluation with dynamic personalized teaching by mentors, so as to provide a useful reference for further promoting the reform of standardized residency training using a hierarchical and progressive teaching model.
5.A Protocol for Developing Chinese Clinical Practice Guidelines of Hypertension
Ying LOU ; Wenjun MA ; Zijun WANG ; Nan YANG ; Yajia SUN ; Yunlan LIU ; Ruobing LEI ; Junxian ZHAO ; Xufei LUO ; Lu WANG ; Yaolong CHEN ; Yaling HAN ; Yingxian SUN ; Yuming LI ; Jun CAI
Cardiology Discovery 2024;04(3):187-191
To improve the standard screening, diagnosis, and treatment of hypertension in patients in China; realize the standardization of clinical practice of hypertension; and improve the prevention and control level of hypertension in China, it is both important and necessary to develop a clinical practice guideline for hypertension according to a recognized methodology. Jointly sponsored by the National Center for Cardiovascular Diseases, Chinese Medical Doctor Association, Hypertension Committee of the Chinese Medical Doctor Association, Chinese Society of Cardiology, and Hypertension Committee of Cross-Straits Medicine Exchange Association, the "Chinese Clinical Practice Guidelines of Hypertension" was proposed. Research Unit of Evidence-Based Evaluation and Guidelines, Chinese Academy of Medical Sciences, Guideline and Standards Research Centre of Chinese Medical Association Publishing House, Lanzhou University Institute of Health Data Science, and Lanzhou University GRADE Center will provide methodological support for the guidelines.
6.A Protocol for Developing Chinese Clinical Practice Guidelines of Hypertension
Ying LOU ; Wenjun MA ; Zijun WANG ; Nan YANG ; Yajia SUN ; Yunlan LIU ; Ruobing LEI ; Junxian ZHAO ; Xufei LUO ; Lu WANG ; Yaolong CHEN ; Yaling HAN ; Yingxian SUN ; Yuming LI ; Jun CAI
Cardiology Discovery 2024;04(3):187-191
To improve the standard screening, diagnosis, and treatment of hypertension in patients in China; realize the standardization of clinical practice of hypertension; and improve the prevention and control level of hypertension in China, it is both important and necessary to develop a clinical practice guideline for hypertension according to a recognized methodology. Jointly sponsored by the National Center for Cardiovascular Diseases, Chinese Medical Doctor Association, Hypertension Committee of the Chinese Medical Doctor Association, Chinese Society of Cardiology, and Hypertension Committee of Cross-Straits Medicine Exchange Association, the "Chinese Clinical Practice Guidelines of Hypertension" was proposed. Research Unit of Evidence-Based Evaluation and Guidelines, Chinese Academy of Medical Sciences, Guideline and Standards Research Centre of Chinese Medical Association Publishing House, Lanzhou University Institute of Health Data Science, and Lanzhou University GRADE Center will provide methodological support for the guidelines.
7.Status and influencing factors of participation in cardiac rehabilitation of cardiovascular nurses
Guozhen SUN ; Yunlan LU ; Yuan CHEN ; Ying WANG ; Li ZHU ; Guiying YOU ; Qi YE ; Jie WANG ; Yi ZHANG ; Guojie LIU ; Guihua HOU
Chinese Journal of Modern Nursing 2023;29(14):1827-1832
Objective:To explore the status and influencing factors of participation in cardiac rehabilitation of cardiovascular nurses.Methods:This is a cross-sectional study. From January to February 2022, a total of 3 047 cardiovascular nurses in members of China Cardiovascular Health Alliance were selected as research objects by convenience sampling method. General data questionnaire and Cardiovascular Nurses Participated in the Cardiac Rehabilitation Questionnaire (CNPCRQ) were used to investigate cardiovascular nurses. Multiple linear regression analysis was used to investigate the influencing factors of participation in cardiac rehabilitation of cardiovascular nurses. A total of 3 047 questionnaires were distributed in this study, and 2 704 valid questionnaires were effectively received, with an effective recovery rate of 88.74%.Results:The total score of CNPCRQ of cardiovascular nurses was (93.23±31.58), which was at a moderate level. Multiple linear regression analysis results showed that age, education, professional title, hospital location, hospital level, position type and hospital type were the influencing factors of participation in cardiac rehabilitation of cardiovascular nurses.Conclusions:The status of participation in cardiac rehabilitation of cardiovascular nurses in China needs to be improved. Role and job content of cardiovascular nurses should be further clarified, and cardiac rehabilitation knowledge and skills training should be strengthened in the future, so as to promote the profession development of cardiac rehabilitation and improve patients' health outcomes.
8.Management process of acceptance of acute myocardial infarction patients with suspected COVID-19 by Cardiac Catheterization Laboratory
Yunlan LU ; Hong YU ; Yawei XU ; Xiaoping ZHU
Chinese Journal of Modern Nursing 2020;26(8):1007-1011
This paper introduced the management process of acceptance of acute myocardial infarction patients with suspected COVID-19 by Cardiac Catheterization Laboratory which carried out general management in many aspects, such as system and process optimization, whole quality prevention and control management as well as special disinfection and isolation. This paper aimed at providing reference for medical staff to ensure the rapid and highly efficient treatment for patient and zero infection in medical staff, and providing basis for clinical nursing, prevention and control work.
9.Effects of traditional Chinese medicine at the acupoint on gastrointestinal function recovery after abdominal surgery
Yiyuan LIU ; Hong CHEN ; Yutao WANG ; Ying LU ; Xiuqin XU ; Hairong HU ; Jialin WANG ; Renghai LIU ; Yunlan JIAO
Chinese Journal of Modern Nursing 2019;25(13):1685-1688
Objective? To explore the clinical effects of traditional Chinese medicine at the acupoint on gastrointestinal function recovery after abdominal surgery. Methods? Totally 84 patients receiving laparoscopy were divided into the observation group (n=42) and the control group (n=42) using randomized, double-blinded and placebo controls. Patients in the observation group received traditional Chinese medicine at the acupoint, while patients in the control group received placebo. Both groups were observed continuously for 3 days. Time of postoperative borborygmus recovery, time of first exhaust, and time of first defecation were compared between the two groups postoperatively, and safety evaluation was performed. Results? The time of borborygmus recovery of the observation group was 15.5 (13-22) h, and the time of first defecation was 45.5 (29-62) h, both lower than those of the control group (Z=2.40, 2.05; P< 0.05). The time of first exhaust of the control group was 18 (15-27) h, and there was no statistically significant difference as compared with the observation group (Z=1.96,P=0.05). Neither group showed adverse effects on local skin after the use of traditional Chinese medicine. Conclusions? Traditional Chinese medicine at the acupoint can promote gastrointestinal function recovery after abdominal surgery, which is simple, easy, cheap and effective and is worth promoting in clinical practice.
10.Nursing for one patient with resistant hypertension underwent bilateral renal denervation therapy by ;cryofocus cryoablation system
Chinese Journal of Modern Nursing 2016;22(31):4569-4570,4571
Objective To report the nursing care for a patient with resistant hypertension underwent bilateral renal denervation therapy by cryofocus cryoablation system.Methods We summarized the nursing care work, which included the operation preparation, observation points, service during the operation, and the essential instruction for inpatient care and future follow-up, for one case of patient with resistant hypertension underwent bilateral renal denervation through the femoral pathway in February 2016. Results The whole operation spent 60 minutes, and after operation, the patient′s blood pressure decreased from 200/110 mmHg to (152.38±24.53)/ (83.65±12.71) mmHg. The operation was successful and the patient was discharged 3 days after operation. In the 3-month follow-up, the 24-hour mean blood pressure was 128/70 mmHg, without the presence of operation-related or nursing-related complications. Conclusions The perioperative nursing care includes the good preoperative preparation, precise nursing during the operation, and further intensive observation, which would facilitate the operation process, avoid the risk, and guarantee the operation quality.

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