Objective:To establish a rapid method for urinary iodine determination based on arsenic-cerium catalytic spectrophotometry using semiconductor water bath rapid cooling digestion technology (rapid cooling method) and an automated iodine analyzer.Methods:Urine samples were collected from three staff members randomly selected at the Gansu Provincial Center for Disease Control and Prevention. The samples were mixed and divided into three equal portions. Using rapid cooling method instead of traditional natural cooling method, the mixed urine sample was lowered from 100 ℃ to the measurement temperature (30 ℃), and then the urine iodine was determined by arsenic cerium catalytic spectrophotometry using a fully automatic iodine analyzer. The differences between the two cooling methods were compared. Additionally, the rapid cooling-arsenic-cerium catalytic spectrophotometry method was validated in terms of the linear equation of the standard curve, precision, accuracy (using urinary iodine reference materials GBW09110e and GBW09109m, and spike recovery experiments), and detection limit.Results:Using the rapid cooling method, the temperature of urine samples reached 30 ℃ in 40 minutes, while the natural cooling method required 120 minutes to reach the same temperature. Urinary iodine levels determined by the rapid cooling method in the three samples were (158.3 ± 1.9), (133.7 ± 2.7), and (219.2 ± 3.1) μg/L, respectively, while those determined by the natural cooling method were (155.5 ± 2.7), (136.2 ± 2.3), and (215.1 ± 3.9) μg/L, respectively. There was no statistically significant difference between the results of the two methods ( t = 1.43, P = 0.192). In the validation experiments for the rapid cooling method, the linear equations for the low-concentration (0 - 300 μg/L) and high-concentration (300 - 1 200 μg/L) iodine standard series were y = - 0.003 0 x + 0.117 5 ( r = - 0.999 7) and y = - 0.001 5 x + 0.649 3 ( r = - 0.999 8), respectively. The precision experiments showed that the relative deviation values of the repeated tests for two different iodine concentrations (300 and 600 μg/L) were 1.99% and 1.90%, respectively. The accuracy experiments demonstrated that the repeated test results for the national urinary iodine reference materials (GBW09110e and GBW09109m) were 216.8 and 134.7 μg/L, respectively, with relative standard deviations of 1.04% and 1.35%, respectively, all within the reference ranges[(218 ± 15) and (135 ± 10) μg/L]. The detection limit was 1.20 μg/L. The spike recovery rate ranged from 92.90% to 99.10%, with an average recovery rate of 96.77%. Conclusions:The rapid cooling-arsenic-cerium catalytic spectrophotometry method not only shortens the time required for urinary iodine determination and improves the speed of measurement, but also provides accurate results, which can be applied when a large number of urine samples need to be measured in a short period of time.

Objective:To establish a rapid method for urinary iodine determination based on arsenic-cerium catalytic spectrophotometry using semiconductor water bath rapid cooling digestion technology (rapid cooling method) and an automated iodine analyzer.Methods:Urine samples were collected from three staff members randomly selected at the Gansu Provincial Center for Disease Control and Prevention. The samples were mixed and divided into three equal portions. Using rapid cooling method instead of traditional natural cooling method, the mixed urine sample was lowered from 100 ℃ to the measurement temperature (30 ℃), and then the urine iodine was determined by arsenic cerium catalytic spectrophotometry using a fully automatic iodine analyzer. The differences between the two cooling methods were compared. Additionally, the rapid cooling-arsenic-cerium catalytic spectrophotometry method was validated in terms of the linear equation of the standard curve, precision, accuracy (using urinary iodine reference materials GBW09110e and GBW09109m, and spike recovery experiments), and detection limit.Results:Using the rapid cooling method, the temperature of urine samples reached 30 ℃ in 40 minutes, while the natural cooling method required 120 minutes to reach the same temperature. Urinary iodine levels determined by the rapid cooling method in the three samples were (158.3 ± 1.9), (133.7 ± 2.7), and (219.2 ± 3.1) μg/L, respectively, while those determined by the natural cooling method were (155.5 ± 2.7), (136.2 ± 2.3), and (215.1 ± 3.9) μg/L, respectively. There was no statistically significant difference between the results of the two methods ( t = 1.43, P = 0.192). In the validation experiments for the rapid cooling method, the linear equations for the low-concentration (0 - 300 μg/L) and high-concentration (300 - 1 200 μg/L) iodine standard series were y = - 0.003 0 x + 0.117 5 ( r = - 0.999 7) and y = - 0.001 5 x + 0.649 3 ( r = - 0.999 8), respectively. The precision experiments showed that the relative deviation values of the repeated tests for two different iodine concentrations (300 and 600 μg/L) were 1.99% and 1.90%, respectively. The accuracy experiments demonstrated that the repeated test results for the national urinary iodine reference materials (GBW09110e and GBW09109m) were 216.8 and 134.7 μg/L, respectively, with relative standard deviations of 1.04% and 1.35%, respectively, all within the reference ranges[(218 ± 15) and (135 ± 10) μg/L]. The detection limit was 1.20 μg/L. The spike recovery rate ranged from 92.90% to 99.10%, with an average recovery rate of 96.77%. Conclusions:The rapid cooling-arsenic-cerium catalytic spectrophotometry method not only shortens the time required for urinary iodine determination and improves the speed of measurement, but also provides accurate results, which can be applied when a large number of urine samples need to be measured in a short period of time.

ObjectiveTo conduct a meta-analysis of the prevalent characteristics of the injury-related behaviors among adolescents in China based on Chinese literature, so as to inform the prevention and control of injury-related behaviors of this population. MethodsA cross-sectional study on the prevalent characteristics of adolescent injury-related behaviors was conducted with the data collected from CNKI, VIP, Wanfang Data, CBM, PubMed, and Web of Science. The review included publications from the inception of the databases to November 2023. Meta-analysis was performed with Stata 15.1 software. ResultsA total of 40 articles were included in this study, and the meta-analysis results showed that cycling violation rate was 38% (95%CI: 32%‒43%), walking violation rate was 29% (95%CI: 22%‒36%), rate of unsafe swimming was 13% (95%CI: 11%‒14%), suicidal ideation rate was 13% (95%CI: 12%‒15%) and the prevalence of fighting was 19% (95%CI: 17%‒22%). Subgroup analysis showed that the cycling violation rate was (44%) for boys and 34% (95%CI: 28%‒40%) for girls. Adolescents in Northeast, East, and Southwest of China had the highest rate of cycling violation (44%), of which junior high school students had the highest rate of violation [42% (95%CI: 36%‒49%)]. As for the walking violation rate, male students [29% (95%CI: 21%‒37%)] was higher than that of female students [22% (95%CI: 15%‒30%)]. Adolescents in North of China had the highest rate of walking violation [54% (95%CI: 30%‒76%)], of which vocational school students accounted for 38% (95%CI:21%‒56%) of the total violation. In terms of the detection rate of unsafe swimming, male students [18% (95%CI: 14%‒24%)] was higher than that of female students [8% (95%CI: 6%‒10%)]. Adolescents in Central South China had the highest rate of unsafe swimming [15% (95%CI: 12%‒18%)], of which, vocational school students accounted for the highest [15% (95%CI: 10%‒19%)]. When it comes to the prevalence of suicidal ideation, female students [16% (95%CI: 13%‒19%)] was higher than that of male students [13% (95%CI: 11%‒15%)]. Adolescents in Southwest of China had the highest rate of suicidal ideation [17% (95%CI: 10%‒25%)], of which high school students accounted for the highest [15% (95%CI: 12%‒18%)]. Finally, the detection rate of fights was 30% (95%CI: 26%‒34%) for boys and 11% (95%CI: 10%‒14%) for girls. Adolescents from Southwest of China had the highest rate [29% (95%CI: 24%‒34%)] for fights, and junior high school students accounted for the highest [26% (95%CI: 22%‒31%)]. ConclusionThe prevalence of harmful behaviors among adolescents in China is notably high, with statistical differences across gender, region, and school stages. These behaviors pose a risk to adolescent health, underscoring the need for targeted interventions by health and educational authorities.

To improve the standard screening, diagnosis, and treatment of hypertension in patients in China; realize the standardization of clinical practice of hypertension; and improve the prevention and control level of hypertension in China, it is both important and necessary to develop a clinical practice guideline for hypertension according to a recognized methodology. Jointly sponsored by the National Center for Cardiovascular Diseases, Chinese Medical Doctor Association, Hypertension Committee of the Chinese Medical Doctor Association, Chinese Society of Cardiology, and Hypertension Committee of Cross-Straits Medicine Exchange Association, the "Chinese Clinical Practice Guidelines of Hypertension" was proposed. Research Unit of Evidence-Based Evaluation and Guidelines, Chinese Academy of Medical Sciences, Guideline and Standards Research Centre of Chinese Medical Association Publishing House, Lanzhou University Institute of Health Data Science, and Lanzhou University GRADE Center will provide methodological support for the guidelines.

To improve the standard screening, diagnosis, and treatment of hypertension in patients in China; realize the standardization of clinical practice of hypertension; and improve the prevention and control level of hypertension in China, it is both important and necessary to develop a clinical practice guideline for hypertension according to a recognized methodology. Jointly sponsored by the National Center for Cardiovascular Diseases, Chinese Medical Doctor Association, Hypertension Committee of the Chinese Medical Doctor Association, Chinese Society of Cardiology, and Hypertension Committee of Cross-Straits Medicine Exchange Association, the "Chinese Clinical Practice Guidelines of Hypertension" was proposed. Research Unit of Evidence-Based Evaluation and Guidelines, Chinese Academy of Medical Sciences, Guideline and Standards Research Centre of Chinese Medical Association Publishing House, Lanzhou University Institute of Health Data Science, and Lanzhou University GRADE Center will provide methodological support for the guidelines.

Objective:To explore the status and influencing factors of participation in cardiac rehabilitation of cardiovascular nurses.Methods:This is a cross-sectional study. From January to February 2022, a total of 3 047 cardiovascular nurses in members of China Cardiovascular Health Alliance were selected as research objects by convenience sampling method. General data questionnaire and Cardiovascular Nurses Participated in the Cardiac Rehabilitation Questionnaire (CNPCRQ) were used to investigate cardiovascular nurses. Multiple linear regression analysis was used to investigate the influencing factors of participation in cardiac rehabilitation of cardiovascular nurses. A total of 3 047 questionnaires were distributed in this study, and 2 704 valid questionnaires were effectively received, with an effective recovery rate of 88.74%.Results:The total score of CNPCRQ of cardiovascular nurses was (93.23±31.58), which was at a moderate level. Multiple linear regression analysis results showed that age, education, professional title, hospital location, hospital level, position type and hospital type were the influencing factors of participation in cardiac rehabilitation of cardiovascular nurses.Conclusions:The status of participation in cardiac rehabilitation of cardiovascular nurses in China needs to be improved. Role and job content of cardiovascular nurses should be further clarified, and cardiac rehabilitation knowledge and skills training should be strengthened in the future, so as to promote the profession development of cardiac rehabilitation and improve patients' health outcomes.

Objective:To investigate the distribution of intraocular pressure (IOP) in high-altitude population aged 18 years and over in Xining, Qinghai and establish the reference interval (RI) of IOP.Methods:A cross-sectional study was conducted in Xining, Qinghai Province at 2.271 km above sea level from September 2019 to May 2020.Ophthalmic examinations and IOP measurement were conducted among subjects from Physical Examination Center of Qinghai Provincial People's Hospital.The subjects who had been living in Xining without leaving for three months were enrolled.Ophthalmic examinations included vision examination, IOP measurement, slit-lamp microscopy, fundus photography, anterior and posterior segment optical coherence tomography.IOP was measured using Goldmann applanation tonometry under local anesthesia.Subjects with factors that could cause significant changes in IOP and affect the accuracy of IOP measurement, and those who were unable to receive IOP measurement were excluded.Subjects were grouped according to sex, age and ethnicity, and the distribution and RI of IOP were compared among all groups.This study adhered to the Declaration of Helsinki.The study protocol was approved by the Ethics Committee of Beijing Tongren Hospital, Capital Medical University (No.TRECKY2017-024). Written informed consent was obtained from each subject.Results:A total of 6 120 subjects (6 120 eyes) aged 18-90 years old were enrolled, including 2 850 males and 3 270 females with average age of (45.54±13.85) years.The average IOP of high-altitude population in Xining, Qinghai Province was (14.32±1.93) mmHg (1 mmHg=0.133 kPa), with the RI of 10.54-18.10 mmHg.The average IOP was (14.42±1.98) mmHg in male with the RI of 10.54-18.30 mmHg, (14.23±1.88) mmHg in female with the RI of 10.55-17.91 mmHg.The IOP of male was higher than that of female ( t=3.71, P<0.001). The IOP of Han, Tibetan, Hui and other nationalities were (14.38±1.91), (13.93±2.06), (14.21±1.87), (13.94±1.95) mmHg, respectively, with a statistically significant overall difference ( F=6.73, P<0.001). The IOP of Han nationality was significantly higher than that of Tibetan, Hui and other nationalities, and the differences were statistically significant (all at P<0.05). Conclusions:RI of IOP in high-altitude population from Xining, Qinghai is lower compared with normal altitude area.

Objective    To analyze the risk factors for acute kidney injury (AKI) after off-pump coronary artery bypass grafting (OPCABG). Methods     The PubMed, EMbase, The Cochrane Library, Web of Science, Wanfang data, CBM, VIP, CNKI were searched by computer for researches on risk factors associated with the development of AKI after OPCABG from the inception to March 2022. The meta-analysis was performed using RevMan 5.4 software. The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of included studies. Results    A total of 18 researches were included, involving 9 risk factors. The NOS score of all included studies was≥6 points. Meta-analysis results showed that age [OR=1.03, 95%CI (1.01, 1.06), P=0.020], body mass index (BMI) [OR=1.10, 95%CI (1.05, 1.15), P<0.001], history of hypertension [OR=1.45, 95%CI (1.27, 1.66), P<0.001], history of diabetes [OR=1.50, 95%CI (1.33, 1.70), P<0.001], preoperative serum creatinine level [OR=2.05, 95%CI (1.27, 3.32), P=0.003], low left ventricular ejection fraction [OR=4.51, 95%CI (1.39, 14.65), P=0.010], preoperative coronary angiography within a short period of time [OR=2.10, 95%CI (1.52, 2.91), P<0.001], perioperative implantation of intra-aortic balloon pump [OR=3.42, 95%CI (2.26, 5.16),  P<0.001], perioperative blood transfusion [OR=2.00, 95%CI (1.51, 2.65), P<0.001] were risk factors for AKI after OPCABG. Conclusion    Age, BMI, history of hypertension, history of diabetes, preoperative serum creatinine level, low left ventricular ejection fraction, preoperative coronary angiography within a short period of time, perioperative implantation of intra-aortic balloon pump, perioperative blood transfusion are risk factors for AKI after OPCABG. Medical staff should focus on monitoring the above risk factors and early identifying, in order to prevent or delay the onset of postoperative AKI and promote early recovery of patients.

Humans ; Hypertension/therapy* ; Publications ; Research Design

Objective:To evaluate the efficacy and safety of limited pars plana vitrectomy(LPPV), pressure-controlled phacoemulsification(PCP), intraocular lens implantation(IOL), and posterior capsulotomy (PC) in treatment of nanophthalmic glaucoma eyes which intraocular pressure(IOP) were still out of control after peripheral iridectomy.Methods:All 24 patients(29 eyes) with nanophthalmic glaucoma whose IOP failed to be reduced after peripheral iridectomy and needed LPPV plus PCP plus IOL plus PC were recruited from July 2017 to April 2021. The age of these patients was(44.6±11.0) years old. Preoperative and postoperative IOP, best corrected visual acuity(BCVA), anterior chamber depth(ACD) and number of glaucoma medications were recorded by chart review and compared by using paired t-test or Wilcoxon signed rank-sum test. P<0.05 was considered as statistical significant. IOP could be controlled in normal range(≥5 mmHg and≤21 mmHg), without both of disease progression and serious complications were regarded as the success criteria of the operation. Surgical success rate was evaluated. Surgery-associated complications were recorded. Results:The average follow-up time was(11.52±12.44) months. After the microsurgery, IOP decreased from(33.12±9.25) mmHg to(14.23±3.44) mmHg( P<0.01); The ACD increased from(1.23±0.46) mm to(2.86±0.62) mm, and the median number of glaucoma medications dropped from 3(3,4) to 3(0,3) at final follow-up visit( P<0.05). There were no significant differences in BCVA( P=0.196) and the degrees of angle closure(AC) ( P=0.478) before and after operation. The total surgical success rate was 86.2%(25/29) at the final follow-up visit. Two eyes suffered from local choroidal detachment which recovered within 2 weeks with medical treatment. Conclusion:LPPV plus PCP plus IOL plus PC is a safe and effective novel surgical procedure in the treatment of nanophthalmic glaucoma patients with uncontrolled IOP after peripheral iridectomy. It could significantly decrease IOP, increase the depth of ACD, reduce the number of glaucoma medications and maintain BCVA. It can be considered as a first choice for the surgical management for patients with a such condition.