ObjectiveTo investigate the epidemiological characteristics and influencing factors of depressive symptoms among middle school (junior, senior, and vocational high school) students in Yunnan Province, China, and to inform evidence-based intervention strategies for adolescent mental health. MethodsA cross-sectional survey was conducted between October and November 2023 using stratified random cluster sampling. Students from eight counties (districts) across four prefectures (cities) in Yunnan Province were included. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale (CES-D). Multivariate logistic regression analysis was performed to examine factors associated with depressive symptoms, with stratified analyses conducted by gender, educational stage, and ethnicity. ResultsA total of 4 672 questionnaires were distributed, with 4 670 valid questionnaires retrieved, yielding a valid response rate of 99.96%. The surveyed participants were predominantly female students (50.81%), junior high school students (49.13%), ethnic minorities (52.78%), and urban residents (79.29%). The mean CES-D score for middle school students in Yunnan Province was (15.31±10.83). Female students had a significantly higher mean score (16.63±11.41) than male students (13.95±10.02) (P<0.001). Senior high school students had a significantly higher mean score (16.61±10.61) compared to both junior high school students (14.74±11.45) and vocational high school students (13.10±7.71) (all pairwise comparisons P<0.001). The prevalence of depressive symptoms among middle school students in Yunnan Province was 28.18%. The prevalence was significantly higher in females (34.09%) than in males (22.07%). By school type, the detection rate was highest among senior high school students (33.39%), followed by junior high school students (26.29%) and vocational high school students (17.27%) (P<0.05). Multivariate logistic regression analysis showed that female gender (OR=2.16, 95%CI: 1.86‒2.50), being in junior high school (OR=2.43, 95%CI: 1.84‒3.20) or senior high school (OR=2.27, 95%CI: 1.73‒2.98), not living with parents (OR=1.24, 95%CI: 1.07‒1.44), irregular breakfast consumption (OR=1.52, 95%CI: 1.33‒1.75), lack of moderate-to-vigorous physical activity (MVPA) (OR=1.69, 95%CI: 1.37‒2.09), sleep duration ≤5 h per night (OR=2.52, 95%CI: 2.02‒3.14) or 6‒7 h per night (OR=1.47, 95%CI: 1.25‒1.73), smoking (OR=1.86, 95%CI: 1.56‒2.23), and alcohol consumption (OR=1.81, 95%CI: 1.54‒2.13) were positively associated with depressive symptoms. In contrast, screen time ≤1 h (OR=0.71, 95%CI: 0.59‒0.86) was negatively associated with depressive symptoms. Stratified analyses showed that female students not living with parents (OR=1.29, 95%CI: 1.06‒1.58), senior high school students (OR=1.51, 95%CI: 1.21‒1.88), and Han Chinese students (OR=1.37, 95%CI: 1.11‒1.69) were more likely to experience depressive symptoms. Han Chinese students who smoked were also more likely to have depressive symptoms (OR=1.72, 95%CI: 1.34‒2.21). In contrast, male students with screen time ≤1 h (OR=0.71, 95%CI: 0.53‒0.95) and ethnic minority students (OR=0.74, 95%CI: 0.58‒0.95) were less likely to experience depressive symptoms. Regardless of gender, irregular breakfast consumption, lack of MVPA, sleep duration less than 8 h per night, smoking, and alcohol consumption were all positively associated with depressive symptoms (P<0.05). Among both junior and senior high school students, irregular breakfast consumption, lack of MVPA, smoking, and alcohol consumption were positively associated with depressive symptoms (all P<0.05), while screen time ≤1 h was negatively associated with depressive symptoms (all P<0.05). For junior high school students, engaging in 1‒2 days of MVPA per week, screen time more than 2 h per day, and sleep duration 6‒7 h per night were all positively associated with depressive symptoms (all P<0.05). Among junior high, senior high, and vocational high school students, sleep duration ≤5 h per night was positively associated with depressive symptoms (P<0.05). For both Han Chinese and ethnic minority students, irregular breakfast consumption, lack of MVPA, sleep duration less than 8 h per night, and alcohol consumption were all positively associated with depressive symptoms (all P<0.05). ConclusionThe prevalence of depressive symptoms among middle school students in Yunnan Province is comparable to that in central China and higher than that in northern regions. Prevention and control efforts should prioritize female students and those in junior and senior high school stages. Universal improvements in lifestyle behaviors among middle school students, such as regular breakfast consumption, MVPA, sufficient sleep (≥8 h), and abstinence from smoking and alcohol. Particular attention should be given to limiting excessive screen time among junior high school students and addressing the mental health needs of females not living with their parents, senior high school students, and Han Chinese students.

Objective : To construct a prediction model for the comorbidity of depressive and anxiety symptoms among middle school students, so as to enable early identification of these symptoms in this population. Methods: From June to August 2025, a multi-stage stratified random cluster sampling method was used to select students from 8 junior high schools and 8 senior high schools across 4 cities in Yunnan Province. Self-administered questionnaires were used to collect demographic information, including age and gender. The Center for Epidemiologic Studies Depression Scale, the Generalized Anxiety Disorder scale, and the Adolescent Self-Rating Life Events Scale were used to assess depressive symptoms, anxiety symptoms, and life stress caused by negative life events in the past year, respectively. A multinomial logistic regression model was employed to screen predictive factors, followed by the development of a random forest model to predict comorbidity of depressive and anxiety symptoms among middle school students. Model performance was evaluated using receiver operating characteristic (ROC) curves and calibration plots. Results: A total of 1 173 middle school students were surveyed, including 569 males (48.51%) and 604 females (51.49%). There were 616 junior high school students (52.51%) and 557 senior high school students (47.49%). The comorbidity of depressive and anxiety symptoms was detected in 238 students, with a detection rate of 20.29%. Multivariable logistic regression analysis revealed that gender (female, OR=1.625, 95%CI: 1.118-2.363), residence (rural area, OR=1.845, 95%CI: 1.202-2.832), left-behind experience (OR=1.665, 95%CI: 1.069-2.595), parenting style (authoritative type, OR=0.301, 95%CI: 0.164-0.554), electronic device usage duration (3-<5 h/d, OR=2.442, 95%CI: 1.242-4.803), sleep deprivation (OR=2.316, 95%CI: 1.574-3.407), and negative life stressors (OR=1.110, 95%CI: 1.093-1.128) were significant risk predictors for comorbidity of depressive and anxiety symptoms among middle school students. The random forest model analysis indicated that the top five variables in terms of importance ranking were negative life stress, residence, left-behind experience, sleep deprivation, and electronic device usage duration. The area under the ROC curve, sensitivity, and specificity were 0.834, 0.731, and 0.792 for the training set, and 0.795, 0.732, and 0.771 for the validation set, respectively. The calibration curves showed good model fit for both the training and validation sets (both P>0.05). Conclusions The comorbidity of depressive and anxiety symptoms among middle school students in this survey is primarily associated with negative life stress, residence, left-behind experience, sleep, and electronic device usage duration. The constructed random forest model demonstrates certain predictive value.

Objective: To investigate the current status and influencing factors of unintentional injuries among middle school students, so as to provide evidence for formulating comprehensive prevention strategies for such injuries. Method: as From September to December 2023, middle school students from four prefectures and cities in Yunnan Province were selected as research subjects by multi-stage stratified random cluster sampling. Data including demographic characteristics, depressive symptoms, lifestyle behaviors, family environment and the occurrence of unintentional injuries in the past one year were collected through questionnaire surveys. A multivariable logistic regression model was used to analyze the influencing factors for unintentional injuries among middle school students. Results: A total of 4 172 middle school students were enrolled, including 1 962 boys (47.03%) and 2 210 girls (52.97%); 2 294 junior high school students (54.99%) and 1 878 senior high school students (45.01%). A total of 406 students suffered from unintentional injuries in the past year, with an incidence of 9.74%. Multivariable logistic regression analysis showed that boy (OR=1.329, 95%CI: 1.064-1.663), depressive symptoms (OR=1.505, 95%CI: 1.194-1.892), smoking (OR=1.436, 95%CI: 1.110-1.853), drinking alcohol (OR=2.066, 95%CI: 1.622-2.630), moderate and high-intensity physical exercise for 4-7 days per week (OR=1.490, 95%CI: 1.086-2.064) and family conflicts (OR=1.363, 95%CI: 1.064-1.735) were associated with higher risks of unintentional injuries among middle school students. Conclusion Approximately 10% of middle school students in Yunnan Province experienced unintentional injuries, which were correlated with gender, depressive symptoms, lifestyle behaviors and family conflicts.

Objective: To understand the current situation of health rooms in primary and secondary schools in Jilin Province, so as to provide the data support for scientific decision making. Methods: From April to July 2023, 512 primary and secondary schools and 1 432 school doctors and health care teachers were selected through convenience sampling method in Jilin Province to conduct an electronic questionnaire survey, including the basic information of the school, the situation of health rooms, personnel setting, and the development of school health work. Results: Among the 512 schools, only 6.4% of the 299 schools that should have clinics had medical institution practice licenses. The compliance rate of clinic area was 16.6%, and the compliance rate of health room area was 75.0%. About 92.1% of the middle schools and 90.6% of the primary schools identified the reporters of infectious diseases, and 90.9% of the primary schools and 85.5% of the secondary schools filed files for students. Totally 73.5% of the staff in the health room were teachers, and only 17.9% were health professionals. Nearly 70.1% of school doctors or health care teachers were engaged in part time jobs, and 60.9% engaged in school health for ≤5 years. In terms of the content in urgent need of training and improvement, the top five were knowledge about first aid (79.7%)，infectious disease prevention and treatment( 73.3 %), health education (64.0%), common disease diagnosis (60.1%) and psychological counseling (53.6%). Conclusions Health care institutions, equipment and facilities in primary and secondary schools in Jilin Province are inadequate, and the construction of school doctors and health care teachers is in need of improvement. It should pay more attention to school health and work together to optimize the team of school doctors and health care teachers.

Authenticity verification is a very important aspect of medical device registration quality management system verification of medical device. How to verify the authenticity of samples is a problem worth discussing. This study analyzes the methods of authenticity verification from the aspects of product retention sample, registration inspection report, traceability of records, hardware facilities and equipment. In order to provide reference for relevant supervisors and inspectors in the verification of registration quality management system.

Modern medical model advocates holistic medical treatment and holistic care, which transforms the concern about diseases in traditional medicine into the concern about people in modern medicine. Narrative medicine, as a tool for practicing holistic medical treatment and holistic care, runs through the whole process of patients’ entering medical procedures. It not only meets the needs of patients’ disease-related narratives, but also provides a new and more comprehensive way of communication for both doctors and patients, which is helpful to promote the comprehensive recovery of patients and the healthy development of doctor-patient relationship. At present, narrative medicine is facing some difficulties in the process of local practice in China. Social work, as one of the main bodies of multi-disciplinary and inter-professional cooperation in the medical field, can give full play to its professional advantages to help the new exploration of narrative medicine practice in China.

Objective: To explore the current prevalence of dyslipidemia in adult population of 9 provinces of China and the epidemic characteristics of this disease. The potential influence of social economic development on dyslipidemia was also observed. Methods: Present research data are derived from the result of the investigation about survey on health and nutrition in China in 2011, in which multistage stratified cluster random sampling method was adopted to investigate the 24 345 individuals in 216 communities from 9 provinces in China and 10 242 blood samples were collected. In this research, 8 669 blood samples of people over 18 years old were selected for final analysis. After adjustment of age, the percentage of dyslipidemia patients in Chinese adults was calculated. Results: The percentage of dyslipidemia in Chinese adults is 39.91% (3 460/8 669). The percentage of dyslipidemia at the age of 18-24, 35-44, 45-59 and over 60 years old were 30.25% (373/1 233),37.19% (774/2 081), 44.22% (1 304/2 949) and 41.94%(1 009/2 406),respectively (χ²=333.02, P<0.01); the percentage of dyslipidemia in male and female population was 51.11% (1 956/3 827) and 31.06%(1 504/4 842), respectively (χ²=60.35, P<0.01); the percentage of dyslipidemia in urban residents and rural residents was 42.56% (1 144/2 687) and 38.72%(2 316/5 982), respectively (χ²=11.72, P<0.01);the percentage of dyslipidemia in high-GDP regions and low-GDP regions was 43.04% (1 567/3 641) and 37.65% (1 893/5 028), respectively (χ²=25.57, P<0.01) .The prevalence of adult hypercholesterolemia in Chinese adult is 9.01% (781/8 669), the prevalence of borderline increased cholesterol is 22.54% (1 954/8 669), the prevalence of hypertriglyceridemia is 27.02% (2 342/8 669), the prevalence of lower high-density lipoproteinemia is 14.36% (1 245/8 669) and the prevalence of increased low-density lipoproteinemia was 10.23% (887/8 669). All prevalence rates are significantly higher compared to the 2005 survey results. Conclusion The prevalence of dyslipidemia in Chinese adults is high and the prevalence increases in a fast pace. The current situation of dyslipidemia in Chinese adults is critical and targeted strategies should be applied to control the dyslipidemia in adult Chinese population.

Objective To explore the clinical characteristics,prevention,and treatment of acute liver injury (AHI) induced by intravenous amiodarone.Methods The medical records data of 5 patients with AHI caused by intravenous amiodarone in our hospital were collected and retrospectively analyzed,and in the meantime,case reports on intravenous amiodarone-induced AHI in PubMed,CNKI and Wanfang Data were searched.The clinical data of 5 patients in our hospital and case reports from the literature were summarized and the clinical characteristics of AHI induced by intravenous amiodarone were analyzed.Results The 5 patients with AHI induced by intravenous amiodarone in our hospital included 3 males and 2 females with ages of 22-70 years.The total doses of amiodarone were 450-750 mg,incubation periods (the period from drug use to AHI occurrence) were 24-48 h,and the types of liver injury were all hepatocyte type,of which 2 patients' were liver failure.A total of 59 patients with amiodarone-induced AHI were collected (5 in our hospital and 54 from the literature),including 40 males (67.8％) and 19 females (32.2％) with ages from 1 year and 10 months to 93 years and a median age of 69 (58,75) years.In these 59 patients,the incubation periods ranged from 6 hours to 8 days and the median period was 2 (1,3) days,and that of 55 patients (93.2％) were less than or equal to 3 days.The incubation periods of 17 patients with liver failure and 42 patients with non-liver failure were 1 (1,2) days and 2 (1,3) days respectively,and the difference was statistically significant (P =0.033).The peak values of ALT,which were recorded in 55 patients,ranged from 178 to 8 400 U/L,and the median value was 2 418 (922,4 250) U/L.The peak values of AST,which were recorded in 56 patients,ranged from 165 to 17 471 U/L,and the median value was 2 658 (1 205,7 250)U/L.The AST peak values of 16 patients with liver failure and 42 patients with non-liver failure were 6 195 (3 370,6 850) U/L and 2 383 (1 115,5 040) U/L,respectively,and the difference was statistically significant (P =0.032).Among the 59 AHI patients,44 patients' liver function returned to normal,4 patients' liver function improved,and 11 patients died,of whom 9 (81.8％) developed liver failure.Conclusion AHI induced by intravenous amiodarone is an acute onset and severe disease with a short incubation period,and should be monitored timely.

Objective To explore the clinical characteristics,prevention,and treatment of acute liver injury (AHI) induced by intravenous amiodarone.Methods The medical records data of 5 patients with AHI caused by intravenous amiodarone in our hospital were collected and retrospectively analyzed,and in the meantime,case reports on intravenous amiodarone-induced AHI in PubMed,CNKI and Wanfang Data were searched.The clinical data of 5 patients in our hospital and case reports from the literature were summarized and the clinical characteristics of AHI induced by intravenous amiodarone were analyzed.Results The 5 patients with AHI induced by intravenous amiodarone in our hospital included 3 males and 2 females with ages of 22-70 years.The total doses of amiodarone were 450-750 mg,incubation periods (the period from drug use to AHI occurrence) were 24-48 h,and the types of liver injury were all hepatocyte type,of which 2 patients' were liver failure.A total of 59 patients with amiodarone-induced AHI were collected (5 in our hospital and 54 from the literature),including 40 males (67.8％) and 19 females (32.2％) with ages from 1 year and 10 months to 93 years and a median age of 69 (58,75) years.In these 59 patients,the incubation periods ranged from 6 hours to 8 days and the median period was 2 (1,3) days,and that of 55 patients (93.2％) were less than or equal to 3 days.The incubation periods of 17 patients with liver failure and 42 patients with non-liver failure were 1 (1,2) days and 2 (1,3) days respectively,and the difference was statistically significant (P =0.033).The peak values of ALT,which were recorded in 55 patients,ranged from 178 to 8 400 U/L,and the median value was 2 418 (922,4 250) U/L.The peak values of AST,which were recorded in 56 patients,ranged from 165 to 17 471 U/L,and the median value was 2 658 (1 205,7 250)U/L.The AST peak values of 16 patients with liver failure and 42 patients with non-liver failure were 6 195 (3 370,6 850) U/L and 2 383 (1 115,5 040) U/L,respectively,and the difference was statistically significant (P =0.032).Among the 59 AHI patients,44 patients' liver function returned to normal,4 patients' liver function improved,and 11 patients died,of whom 9 (81.8％) developed liver failure.Conclusion AHI induced by intravenous amiodarone is an acute onset and severe disease with a short incubation period,and should be monitored timely.

Objective: To study the clinical features and treatment of children with influenza, and provide evidence for clinical screening and appropriate treatment timely. Methods: Epidemiology, clinical manifestations, laboratory features and drug therapy of 978 pediatric patients with influenza in Beijing New Century International Children's Hospital in 2014 were analyzed retrospectively. Results: Among the 978 pediatric patients with influenza, 90.8%were outpatients, while 9.92% were inpatients. The incidence was the highest in winter (85.28%). The age of most cases ranged from 1 to 5 years (57.16%). The cases with type A influenza accounted for 81.29%. High fever (99.59%) and cough (85.89%) were the two main symptoms. The average count of WBC was 6.86±2.68×10⁹/L, lymphocyte percentage was lower than the proportion of neutrophils. CRP was normal (66.16%) or slightly-increased (19.00± 15.12 mg/l). Compared with type A influenza, digestive tract symptoms were more common in cases with type B (P=0.000). Analysis of 97 hospitalized cases: the main diagnosis was lower respiratory tract infection (71.13%). Nearly 23.71% cases had been detected to have combined infection with other pathogenic agents. Course of fever in cases who started taking oseltamivir after fever of 48 hours was significantly longer than those who took within 48 hours (P=0.000). Seven severe pneumonia cases were mainly in young children, cases with underlying disease or mixed infection, they were all cured by active and comprehensive therapy. Conclusions Influenza in children is characterized by high fever and cough, digestive tract symptoms frequently occurred in patients with type B influenza. Early application of oseltamivir could signficantly shorten the period of fever. Severe cases should be given active and comprehensive treatments.