Background: The prevalence of long-term prescriptions, often exceeding six months, has increased in recent years. This raises con-cerns about potential risks to patient safety due to insufficient monitoring of changes in patient conditions after initiating treatment. Objectives: This study investigates community pharmacists’ perceptions of long-term prescriptions exceeding 90 days, focusing on dispensing practices, perceived advantages and disadvantages, and strategies to minimize associated risks. Methods: After informing 735 pharmacists from a single pharmacy chain about the study’s purpose and content, an online survey was conducted among those who consented to participate. A total of 267 pharmacists responded between July 6 and July 13, 2024. Data were collected using a Google Forms questionnaire and analyzed using chi-square tests with a significance level of 0.05. Results: 88.8% of pharmacists reported dispensing long-term prescriptions (≥90 days) daily, with 50-70% involving unit dose packing. Reduced patient visits and resulting cost saving were noted as benefits of long-term prescriptions. Concerns included risks such as decreased stability due tolong-term storage, polypharmacy, reduced medication adherence, and drug waste. The main reasons for discarded medications were prescription changes (66.7%) and overlaps with other medications (26.2%). Conclusions Long-term prescriptions can undermine the safety of drug use and lead to issues such as costs associated with drug disposal. Therefore, policy efforts are needed to addressthese concerns.