Purpose: To report a case of improvement of neovascular age-related macular degeneration (nAMD) that did not respond to intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment after vitrectomy for retinal detachment.Case summary: A 69-year-old man visited the hospital with a sudden onset of decreased vision in his left eye the day prior to presentation. He had been receiving treatment for nAMD for the previous seven years and had experienced repeated improvements and relapses despite intravitreal anti-VEGF injections. A fundus examination at the time of presentation showed retinal detachment due to a retinal tear at 11 o’clock, for which vitrectomy was performed. After surgery, nAMD improved and has not recurred to date. Conclusions This case demonstrated change of nAMD progression after vitrectomy. Further studies are needed on the effect of vitrectomy on progression of nAMD.

BACKGROUND: The relationship between serum homocysteine levels and non-alcoholic fatty liver disease is poorly understood. This study aims to investigate the sex-specific relationship between serum homocysteine level and non-alcoholic fatty liver disease in the Korean population. METHODS: This cross-sectional study included 150 men and 132 women who participated in medical examination programs in Korea from January 2014 to December 2014. Patients were screened for fatty liver by abdominal ultrasound and patient blood samples were collected to measure homocysteine levels. Patients that consumed more than 20 grams of alcohol per day were excluded from this study. RESULTS: The homocysteine level (11.56 vs. 8.05 nmol/L) and the proportion of non-alcoholic fatty liver disease (60.7% vs. 19.7%) were significantly higher in men than in women. In men, elevated serum homocysteine levels were associated with a greater prevalence of non-alcoholic fatty liver disease (quartile 1, 43.6%; quartile 4, 80.6%; P=0.01); however, in females, there was no significant association between serum homocysteine levels and the prevalence of non-alcoholic fatty liver disease. In the logistic regression model adjusted for age and potential confounding parameters, the odds ratio for men was significantly higher in the uppermost quartile (model 3, quartile 4: odds ratio, 6.78; 95% confidential interval, 1.67 to 27.56); however, serum homocysteine levels in women were not associated with non-alcoholic fatty liver disease in the crude model or in models adjusted for confounders. CONCLUSION: Serum homocysteine levels were associated with the prevalence of non-alcoholic fatty liver disease in men.
Cross-Sectional Studies ; Fatty Liver ; Female ; Homocysteine* ; Humans ; Korea ; Logistic Models ; Male ; Non-alcoholic Fatty Liver Disease* ; Odds Ratio ; Prevalence ; Sex Characteristics* ; Ultrasonography

No abstract available.