Objective:To investigate the longitudinal relationships among resilience, social support, and negative emotions in college students.Methods:Questionnaire surveys were administered to 1 739 college students from a university in Hebei Province born in the same year in November 2020 and November 2021 respectively, and 1 183 valid responses were finally obtained. The survey battery comprised the 11-item resilience scale, the social support questionnaire, and the 21-item depression anxiety stress scales. Cross-lagged panel analysis was conducted using Mplus 8.3 software. Mediating effects were tested via the Bootstrap method.Results:The scores of resilience, social support and negative emotion at T1 were 58 (51, 65), 57 (51, 66), and 3 (0, 10), respectively. The scores of resilience, social support and negative emotion at T2 were 59 (48, 66), 56 (44, 65), and 11 (1, 24), respectively. Resilience at T1 and T2 were significantly and positively correlated with social support at T1 and T2 ( r=0.66, 0.75, 0.40, 0.33, all P<0.01), while negatively correlated with negative emotion at T1 and T2( r=-0.45, -0.23, -0.26, -0.24, all P<0.01). Social support at T1 and T2 were negatively correlated with negative emotion at T1 and T2( r=-0.44, -0.28, -0.28, -0.28, all P<0.01). T1 resilience significantly and positively predicted T2 resilience ( β=0.35) and T2 social support ( β=0.15). T1 social support significantly and positively predicted T2 resilience ( β=0.07) and T2 social support ( β=0.35), while negatively predicted T2 negative emotion ( β=-0.15). T1 negative emotion significantly and negatively predicted T2 resilience ( β=-0.06) and T2 social support ( β=-0.07). The total effect of T1 resilience on T2 negative emotion was -0.35, and the mediating effect of T2 social support was -0.09, accounting for 25.71% of the total effect. Conclusion:T2 social support partially mediates the relationship between T1 resilience and T2 negative emotions.

Objective:To investigate the longitudinal relationships among resilience, social support, and negative emotions in college students.Methods:Questionnaire surveys were administered to 1 739 college students from a university in Hebei Province born in the same year in November 2020 and November 2021 respectively, and 1 183 valid responses were finally obtained. The survey battery comprised the 11-item resilience scale, the social support questionnaire, and the 21-item depression anxiety stress scales. Cross-lagged panel analysis was conducted using Mplus 8.3 software. Mediating effects were tested via the Bootstrap method.Results:The scores of resilience, social support and negative emotion at T1 were 58 (51, 65), 57 (51, 66), and 3 (0, 10), respectively. The scores of resilience, social support and negative emotion at T2 were 59 (48, 66), 56 (44, 65), and 11 (1, 24), respectively. Resilience at T1 and T2 were significantly and positively correlated with social support at T1 and T2 ( r=0.66, 0.75, 0.40, 0.33, all P<0.01), while negatively correlated with negative emotion at T1 and T2( r=-0.45, -0.23, -0.26, -0.24, all P<0.01). Social support at T1 and T2 were negatively correlated with negative emotion at T1 and T2( r=-0.44, -0.28, -0.28, -0.28, all P<0.01). T1 resilience significantly and positively predicted T2 resilience ( β=0.35) and T2 social support ( β=0.15). T1 social support significantly and positively predicted T2 resilience ( β=0.07) and T2 social support ( β=0.35), while negatively predicted T2 negative emotion ( β=-0.15). T1 negative emotion significantly and negatively predicted T2 resilience ( β=-0.06) and T2 social support ( β=-0.07). The total effect of T1 resilience on T2 negative emotion was -0.35, and the mediating effect of T2 social support was -0.09, accounting for 25.71% of the total effect. Conclusion:T2 social support partially mediates the relationship between T1 resilience and T2 negative emotions.

Objective To observe the value of tissue motion mitral annular displacement(TMAD)technique to assess left ventricular function in patients with cardiac amyloidosis.Methods A total of 34 adult patients with cardiac amyloidosis diagnosed by pathology were retrospectively included as the observation group,and 32 healthy adults were collected as the control group for the same period.Basic data of the subjects were collected,and data of routine ultrasonic parameters of left ventricular function and TMAD parameters were obtained,and then compared between groups.The correlation of TMAD parameters with left ventricular ejection fraction(LVEF)or mitral annular plane systolic excursion(MAPSE)were assessed.Results Compared with the control group,the observation group had higher levels of body surface area(BSA),systolic blood pressure,N-terminal pro-B-type natriuretic peptide(NT-proBNP),creatinine and urea(all P＜0.05).The observation group had increased values of ascending aorta(AO),left atrium(LA),interventricular septum(IVS),left ventricular posterior wall thickness in diastole(LVPWD),pulmonary artery(PA),and early diastolic peark velocity of mitral inflow(peak E),while smaller values of left ventricular end-diastolic dimension(LVEDD),LVEF,fractional shortening(FS),early diastolic tissue Doppler velocity E'septal(IVS E')and lateral(LW E')and MAPSE(all P＜0.05),and the LVEF in observation group was(58.18±7.09)％.For TMAD patameters,the observation group had smaller values of the following parameters on apical four chamber(A4C)view as medial displacement of mitral valve annulus(A4C MV1),displacement of lateral mitral valve annulus(A4C MV2),displacement of the midpoint of the mitral valve annulus(A4C Midpt)and the corresponding percentage(A4C Midpt％),as well as smaller values of the following paramets on apical two chamber(A2C)view as A2C MV1,A2C MV2,A2C Midpt and A2C Midpt％(all P＜0.05).In the observation group,A4C Midpt％showed a moderate positive correlation with LVEF(r=0.488,P＜0.05),and A2C Midpt showed a high positive correlation with M APSE(r=0.712,P＜0.05),and A4C MV2,A4C Midpt,A4C Midpt％,A2C MV1,A2C MV2,A2C Midpt％all showed a moderate positive correlation with MAPSE(r=0.420 to 0.691,all P＜0.05).Conclusion Compared with LVEF,the TMAD parameters might reflect the changes in left ventricular systolic function more sensitively in patients with cardiac amyloidosis.

Objective This study aims to establish a non-puerperal mastitis (NPM) rat model by simulating hyperprolactinemia and immune-inflammatory states, and to evaluate its local inflammatory characteristics in the mammary gland, thereby laying the foundation for research on the diagnosis and treatment of this clinically challenging disease. Methods Twelve SPF-grade Wistar female rats were evenly divided into a control group and a model group. During the experiment, the control group received no experimental treatment or medication. The model group received daily subcutaneous injections of 100 mg/kg metoclopramide hydrochloride for 7 consecutive days. Serum prolactin (PRL) levels were measured using ELISA on the 10th, 20th, and 30th days after the first injection. After 7 days of injections, 200 μL of lactating SD rat milk was mixed with 200 μL of complete Freund's adjuvant to prepare an oil-in-water emulsion, which was administered by multiple subcutaneous injections into the back of the Wistar rats for the initial immunization. Seven days after the initial immunization, the emulsion was injected subcutaneously into the third, fourth, and fifth mammary glands for the final immunization. After the final immunization, the rats were observed for 28 days for changes in mammary gland appearance, and the size of mammary nodules was calculated. On the 3rd, 7th, 14th, and 28th days, hematoxylin-eosin (HE) staining was used to analyze mammary tissue morphology. Immunohistochemistry was employed to detect CD138 expression levels. ELISA was used to measure the levels of interleukin (IL)-6, IL-1β, tumor necrosis factor (TNF)-α, and inducible nitric oxide synthase (iNOS) in mammary tissue to comprehensively assess the model. Results Rats in the model group exhibited mammary skin ulceration and foul odor at the ulcer sites. Palpation and ultrasound revealed the formation of mammary nodules. HE staining showed that on the 3rd day after the final immunization, normal ductal and lobular structures in the mammary glands disappeared, with significant infiltration of plasma cells. On the 7th day, ductal dilation, epithelial necrosis and detachment, and pronounced periductal plasma cell and lymphocyte (predominantly T-lymphocytes) infiltration were observed. On the 14th day, there was a proliferation of fibrofatty tissue, small blood vessels, and granulation tissue, with scattered plasma cells in the interstitium. By the 28th day, inflammatory cell infiltration and fibrous tissue proliferation were reduced, with granuloma formation. Serum PRL levels in the model group were significantly increased on the 10th day (P<0.05) and the 20th day (P<0.001). IL-6 and TNF-α levels in mammary tissue were higher in the model group compared to the control group on the 3rd, 7th, 14th, and 28th days (P<0.05). IL-1β levels were higher on the 3rd, 7th, and 14th days compared with the control group (P<0.01) but lower than the control group on the 28th day (P>0.05). iNOS levels were significantly higher on the 7th day after the final immunization (P<0.001). Conclusion A successful NPM model was established in rats, which exhibited typical pathological features such as local mammary masses, abscesses, ulcers, ductal dilation and plasma cell infiltration. This model can serve as a foundation for further research into the diagnosis and treatment of this clinically challenging disease.

Peak Torque(PT),Total Work(TW),Average Power(AP),Torque Acceleration Energy(TAE),Set Total Work(STW),Endurance Ratio (ER)and DOrsal/plantar ratio of ankle dorsal and plantarflexion were tested in 101 patients with lumbar disc protrusion using a Cybex一6000 isokinetic muscle test-ing instrument.The results showed the most tested of the affected side was signficantly lower than that onthe opposite side. The PT,TW and STW of the affected side was lower 70一80%than that on the oppo-site side. The rest was lower 20一30%than another side. No significant difference of endurance ratios be-tween the affected and unaffected sides was noted.