Severe congenital neutropenia(SCN)is a rare disease characterized by the absolute neutrophil count(ANC)less than 0.5× 109/L in peripheral circulating blood.Due to the low neutrophil count,there is an increased risk of bacterial infection.And the most common oral manifestations are severe periodontitis and recurrent oral ulcer.This paper reports a 5-year-old girl with SCN and severe pe-riodontitis.On the basis of systemic treatment,the periodontal inflammation was controlled to a certain extent through periodontal non-sur-gical treatment and regular plaque control by using the WeChat platform for follow-up and oral hygiene.

Objective To explore the effect of Huangqi Danzhi Shenmai Decoction in treatment of coronary atherosclerosis patients with qi deficiency and blood stasis syndrome and its influence on the levels of serum malondialdehyde(MDA),superoxide dismutase(SOD),tumor necrosis factor-α(TNF-α),and interleukin-1 β(IL-1β).Methods A total of 120 patients with coronary atheroscle-rosis were selected and randomly divided into control group(conventional treatment+simvastatin)and observation group(conventional treatment+Huangqi Danzhi Shenmai Decoction)by random number table method,with 60 cases in each group.The clinical efficacy of the two groups was evalua-ted.The changes in traditional Chinese medicine(TCM)syndrome scores,blood lipids,inflammatory factors,and oxidative stress indicators before and after treatment were recorded for both groups.Re-sults The total effective rate in the observation group was higher than that in the control group(P＜0.05).After treatment,the TCM syndrome scores in the observation group were lower than those in the control group(P＜0.05).The improvement in blood lipid indicators was more pronounced in the observation group compared to the control group(P＜0.05).The serum levels of TNF-α,IL-1 β,and MDA in the observation group were lower than those in the control group,while the serum levels of SOD and glutathione peroxidase(GSH-PX)were higher than those in the control group,with statis-tically significant differences(P＜0.05).No severe adverse reactions occurred in either group dur-ing the treatment period.Conclusion Huangqi Danzhi Shenmai Decoction has a good clinical effi-cacy in treating coronary atherosclerosis with qi deficiency and blood stasis syndrome,and can im-prove the oxidative stress status,reduce inflammatory responses,and regulate blood lipid levels in patients,so it is worthy of clinical promotion and use.

Severe congenital neutropenia(SCN)is a rare disease characterized by the absolute neutrophil count(ANC)less than 0.5× 109/L in peripheral circulating blood.Due to the low neutrophil count,there is an increased risk of bacterial infection.And the most common oral manifestations are severe periodontitis and recurrent oral ulcer.This paper reports a 5-year-old girl with SCN and severe pe-riodontitis.On the basis of systemic treatment,the periodontal inflammation was controlled to a certain extent through periodontal non-sur-gical treatment and regular plaque control by using the WeChat platform for follow-up and oral hygiene.

Complicated crown root fracture is a serious combined fracture of the enamel,dentin,and cementum in dental trauma.The treatment method is complicated.During the procedure,the condition of pulp,periodontal,and tooth body should be thoroughly evaluated,and a multidisciplinary approach combined with sequential treatment is recom-mended.This case reported the different treatment and repair processes of one case of two affected teeth after complicat-ed crown root fracture of upper anterior teeth,including regrafting of broken crown after flap surgery at the first visit,di-rect resin repair to remove broken fragments,and pulp treatment and post-crown repair at the second visit.After 18 months of follow-up,the preservation treatment of the affected teeth with complicated crown root fracture was achieved.Therefore,fragment reattachment and post-crown restoration are feasible treatment options for children with complicated crown root fracture.

Objective To compare the size discrepancy between ultrasonic and pathological measurement of solitary cN0M0 papillary thyroid microcarcinoma(PTMC),and to explore their correlation with lymph node metastasis.Methods From April 2021 to January 2022,234 patients with solitary cN0M0 PTMC who received thyroid lobectomy or total thyroidectomy in the Department of Thyroid and Breast Surgery of Nanjing University of Chinese Medicine,Affiliated Hospital of Integrated Traditional Chinese and Western Medicine were analyzed retrospectively.The size discrepancy between ultrasonic and pathological measurement were compared,and the risk factors of central lymph node metastasis were analyzed.Results The mean of maximum diameter of PTMC measured by ultrasound was 6.8(range 5.6 to 8.4)mm,which was significantly bigger than that measured by pathology 5.0(range 4.0 to 7.0)mm(P=0.000).Of them,37.2%of the tumor size measured by ultrasound is consistent with pathology,61.1%of the tumor size measured by ultrasound is bigger than that measured by pathology,and only 1.7%of the tumor size measured by ultrasound is smaller than that measured by pathology.There was a linear correlation between the diameter measured by ultrasound and pathology.And the regression equation can be expressed as:pathological diameter=0.799×ultrasonic diameter-0.221.In addition,28.6%patients had central lymph node metastasis.Multivariate Logistic regression analysis showed that the diameter measured by pathology is a risk factor for central lymph node metastasis in patients(OR=17.845,95%CI:2.507-127.025,P=0.004),and the cutoff value is 5.5 mm which corresponded to the diameter measured by ultrasound as 7.2 mm.Conclusions The sizes of solitary cN0M0 PTMC measured by ultrasound and pathology are different but also correlated.PMTC with pathological diameter>5.5 mm with its corresponding ultrasonic diameter as 7.2 mm indicated an increased risk of central lymph node metastasis.

Objective:To investigate the med- to long-term clinical outcomes of open reduction and cannulated screw fixation via the modified Smith-Petersen approach for irreducible femoral neck fractures in young adults.Methods:The clinical data of 16 young adults were retrospectively studied who had been treated for irreducible femoral neck fractures by open reduction and cannulated screw fixation via the modified Smith-Petersen approach by the same surgeon from December 2009 to February 2015 at Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital. There were 11 males and 5 females aged from 19 to 59 years (average, 42.9 years). All their fractures were closed Garden type Ⅳ, with high energy injury in 8 cases and low energy injury in the other 8 ones. The time from injury to surgery averaged 5.4 d (from 1 to 11 d). In all the patients, open reduction and cannulated screw fixation via the modified Smith-Petersen approach was conducted after ideal reduction had not been achieved by 3 continuous attempts in primary closed reduction in a traction bed. Recorded were the postoperative full weight-bearing time, return to work time, fracture union time, function of the affected hip and complications at the last follow-up in the patients.Results:The 16 patients were followed up for 6 to 12 years (average, 8.8 years). The postoperative full weight-bearing time averaged 12.7 weeks (from 2 to 16 weeks) in 16 patients; the return to work time averaged 15.0 weeks (from 3 to 20 weeks) and the fracture union time 3.5 months (from 3 to 6 months) in 15 patients while fracture nonunion happened in the other one. The HSS hip scores at the last follow-up averaged 90.3 points (from 62 to 98 points), yielding 12 excellent, 2 good, one fair and one poor cases. The one case with fracture nonunion underwent total hip arthroplasty (THA); of the 4 cases with avascular necrosis of the femoral head, 2 underwent THA; limited range of hip motion due to heterotopic ossification was noted in one case.Conclusion:Open reduction and cannulated screw fixation via the modified Smith-Petersen approach may lead to fine med- to long-term clinical outcomes in young adults whose femoral neck fracture cannot be reduced by closed reduction, because the modified Smith-Petersen approach allows fracture reduction under direct vision.

Objective: To investigage the three-dimensional changes in condylar position after bilateral sagittal split ramus osteotomy (BSSRO) in skeletal class Ⅲpatients with mandibular deviation using cone-beam CT (CBCT). Methods: Twenty-five skeletal class Ⅲ patients with mandibular deviation were included. The patients (12 males and 13 females, aged 19-25 years, average age 22.4 years) were treated in the Department of Orthodontics, Affiliated Stomatological Hospital, Nanchang University from October 2013 to March 2017. The patients were divided into T1, T2 and T3 groups (T1 group: CBCT taken within 1 week before operation; T2 group: CBCT taken within 1 week after operation; T3 group: CBCT taken 6-8 months after surgery). Three sets of image data of condyles on both sides (deviation side and contralateral side) were obtained. After the DICOM data collection, the software of Mimics 17.0 was used to perform three-dimensional reconstruction and condylar position measurements: the distance from the condylar top (CoT) to the standard horizontal plane (SHP), the middle sagittal plane (MSP) and the sella coronal plane (SCP) (CoT-SHP, CoT-MSP, CoT-SCP); the distance from the condylar center (CoC) to SHP, MSP and SCP (CoC-SHP, CoC-MSP, CoC-SCP); the angle from the condyle cella plane (CCP) to SHP, MSP and SCP (CCP-SHP, CCP-MSP, CCP-SCP); the angle from the condyle sagittal plane (CSP) to SHP, MSP and SCP (CSP-SHP, CSP-MSP, CSP-SCP) and the distance of the anterior, superior, posterior, medial, central and lateral joint space. One-way ANOVA and LSD-t test were used to compare the changes in condylar position at different periods (T1, T2, and T3). Results: Within 1 week before operation on the deviation side, CoT-SHP [(2.5±1.3) mm], CSP-MSP (41.2°±8.4°) and the posterior joint space [(2.0±0.6) mm] were obviously increased (P<0.05), and CoT-SCP [(9.1±3.3) mm], CCP-MSP (78.2°±5.2°) were decreased significantly (P<0.05); on the contralateral side, CoT-MSP [(50.4±3.1) mm], CCP-MSP (80.6°±6.0°), the anterior joint space [(2.2±0.6) mm] and the medial joint space [(2.6±0.6) mm] were obviously increased (P<0.05), and CCP-SCP (11.4°±8.8°) were decreased significantly (P<0.05). Six to eight months after surgery, CoT-SHP [(2.2±1.0) mm] and the posterior joint space [(1.9±0.5) mm] on deviation side and CoT-SCP [(8.4±2.8) mm] on the contralateral side were increased significantly (P<0.05). No significant difference was found in other measurements (P>0.05). Conclusions The condylar position in skeletal class Ⅲ patients with mandibular deviation was asymmetrical. Within 1 week after the operation of BSSRO, the condyle on the deviation side was moved forward, downward and inward. Meanwhile, the condyle on the contralateral side was moved backward and outward. Six to eight months after surgery, the condylar position on both sides was gradually restored to the pre-operative condylar position.

To investigage the three?dimensional changes in condylar position after bilateral sagittal split ramus osteotomy (BSSRO) in skeletal classⅢpatients with mandibular deviation using cone?beam CT (CBCT). Methods Twenty?five skeletal class Ⅲ patients with mandibular deviation were included. The patients (12 males and 13 females, aged 19?25 years, average age 22.4 years) were treated in the Department of Orthodontics, Affiliated Stomatological Hospital, Nanchang University from October 2013 to March 2017. The patients were divided into T1, T2 and T3 groups (T1 group: CBCT taken within 1 week before operation; T2 group: CBCT taken within 1 week after operation; T3 group: CBCT taken 6?8 months after surgery). Three sets of image data of condyles on both sides (deviation side and contralateral side) were obtained. After the DICOM data collection, the software of Mimics 17.0 was used to perform three?dimensional reconstruction and condylar position measurements: the distance from the condylar top (CoT) to the standard horizontal plane (SHP), the middle sagittal plane (MSP) and the sella coronal plane (SCP) (CoT?SHP, CoT?MSP, CoT?SCP); the distance from the condylar center (CoC) to SHP, MSP and SCP (CoC?SHP, CoC?MSP, CoC?SCP); the angle from the condyle cella plane (CCP) to SHP, MSP and SCP (CCP?SHP, CCP?MSP, CCP?SCP); the angle from the condyle sagittal plane (CSP) to SHP, MSP and SCP (CSP?SHP, CSP?MSP, CSP?SCP) and the distance of the anterior, superior, posterior, medial, central and lateral joint space. One?way ANOVA and LSD-t test were used to compare the changes in condylar position at different periods (T1, T2, and T3). Results Within 1 week before operation on the deviation side, CoT?SHP [(2.5±1.3) mm], CSP?MSP (41.2°±8.4°) and the posterior joint space [(2.0±0.6) mm] were obviously increased (P<0.05), and CoT?SCP [(9.1±3.3) mm], CCP?MSP (78.2°±5.2°) were decreased significantly (P<0.05); on the contralateral side, CoT?MSP [(50.4±3.1) mm], CCP?MSP (80.6°±6.0°), the anterior joint space [(2.2±0.6) mm] and the medial joint space [(2.6±0.6) mm] were obviously increased (P<0.05), and CCP?SCP (11.4°±8.8°) were decreased significantly (P<0.05). Six to eight months after surgery, CoT?SHP [(2.2± 1.0) mm] and the posterior joint space [(1.9±0.5) mm] on deviation side and CoT?SCP [(8.4±2.8) mm] on the contralateral side were increased significantly (P<0.05). No significant difference was found in other measurements (P>0.05). Conclusions The condylar position in skeletal classⅢpatients with mandibular deviation was asymmetrical. Within 1 week after the operation of BSSRO, the condyle on the deviation side was moved forward, downward and inward. Meanwhile, the condyle on the contralateral side was moved backward and outward. Six to eight months after surgery, the condylar position on both sides was gradually restored to the pre?operative condylar position.

Schistosomiasis is one of the major infectious diseases that seriously endanger the health of people, and social and economic development. Before the year of 1949, Yujiang County of Jiangxi Province was one of hyper-endemic regions for schistosomiasis. After the founding of the People’s Republic of China, under the leadership and high attention of the Chinese Communist Party and the government, after the arduous struggle with schistosomiasis, Yujiang County became the first county that reached the standard of eradication of schistosomiasis in 1958. Moreover, Chairman Mao Zedong gladly wrote the famous poem of "Farewell to the God of Plague". Since then, the work of schistosomiasis control has been greatly inspired by the poem. In 2016, Yujiang County became the first county of schistosomiasis elimination in Jiangxi Province. In this paper, the experience and process of eradication and elimination of schistosomiasis in Yujiang County are systematically reviewed and summarized by analyzing the endemic situation of schistosomiasis before and after the eradication and elimination in Yujiang County, to expound the significance and enlightenment of the schistosomiasis control in Yujiang County. This paper commemorates the 60th anniversary of the publication of Mao Zedong’s poem.

Objective To investigate the effect of laser‐doppler flowmetry (LDF) in the evaluation of established canine spi‐nal cord injury(SCI) model .Methods Totally 15 beagle dogs were randomly divided into the group A ,B and C .Through the im‐proved numerical control SCI apparatus ,different impacts and compression time were adopted to establish the different acute SCI models .The group A was 1 .2 m/s+5 mm+5 mm+15 mns ,the group B was 1 .2 m/s+5 mm+5 mm+10 mns ,while the group C wastakenasthecontrolgroup.LDFwasusedtomeasurethespinalcordbloodflow(SCBF)chart,thepathologicchangewasevalu‐ated by measuring the spinal cord necrosis area .Results The SCBF chart in 3 groups measured by LDF showed that the decrease of SCBF in the group A was most obvious ,the injury degree in the group A was more severe than those in the group B and C ,the difference was statistically significant(P<0 .05) .The motor evoked potential displayed that the decrease degree of SCBF was close‐ly related with the prognosis and motion function .Conclusion LDF could effectively judge the degree of spinal injury and SCBF sit‐uation ,which has a good application prospect in animal experiments and clinical field .