Objective To explore the correlation between preoperative airway preparation and postoperative day 1 drainage volume in patients undergoing radical esophagectomy and the occurrence of postoperative pulmonary complications.Methods Analyzing the clinical data of esophageal cancer 147 patients who underwent thoracoscopic and laparoscopic radical surgery from January 2022 to June 2024,they were divided into PPCs group and non-PPCs group based on whether PPCs occurred postoperatively.Clinical data of the two groups were compared.Multivariate logistic regression analysis was applied to analyze the influencing factors for the occurrence of PPCs after radical resection of esophageal cancer,and a decision tree prediction model for postoperative PPCs was constructed.Receiver operating characteristic(ROC)curve was used to analyze the value of related factors in predicting the occurrence of PPCs after radical resection of esophageal cancer.Results Univariate analysis showed that age,albumin/fibrinogen ratio,neutrophil/lymphocyte ratio,preoperative respiratory preparation,and drainage volume on the first day after surgery were associated with the occurrence of PPCs after radical resection of esophageal cancer(P＜0.05).Multivariate logistic regression analysis indicated that age,albumin/fibrinogen ratio and drainage volume on the first day after surgery were independent influencing factors for the occurrence of PPCs after radical resection of esophageal cancer(P＜0.05).The decision tree model identified drainage volume on the first day after surgery,albumin/fibrinogen ratio,age and neutrophil/lymphocyte ratio as predictive factors.The incidence rate of PPCs in the group without preoperative respiratory preparation was significantly higher than that in the group with preoperative respiratory preparation(62.5％vs.37.5％,P＜0.05).A drainage volume of 246.59 ml on the first day after surgery was the optimal cutoff value for predicting the occurrence of PPCs after radical resection of esophageal cancer,and specificity was 93.04％,sensitivity was 87.5％,area under ROC curve(AUC)was 0.958,95％CI was 0.911-0.984.Moreover,the incidence rate of PPCs in patients with a drainage volume≤246.59 ml on the first day after surgery was significantly higher than that in patients with a drainage volume＞246.59 ml(77.78％vs.3.60％,P＜0.01).Conclusion Preoperative airway preparation and postoperative drainage volume are closely related to the occurrence of postoperative pulmonary complications(PPCs)after thoracoscopic radical surgery for esophageal cancer.Therefore,targeted measures should be taken for airway preparation before surgery,and changes in the patient's condition should be closely monitored after surgery to accurately determine the timing of drainage tube removal,which plays an important role in effectively preventing and treating PPCs.

Objective To explore the correlation between preoperative airway preparation and postoperative day 1 drainage volume in patients undergoing radical esophagectomy and the occurrence of postoperative pulmonary complications.Methods Analyzing the clinical data of esophageal cancer 147 patients who underwent thoracoscopic and laparoscopic radical surgery from January 2022 to June 2024,they were divided into PPCs group and non-PPCs group based on whether PPCs occurred postoperatively.Clinical data of the two groups were compared.Multivariate logistic regression analysis was applied to analyze the influencing factors for the occurrence of PPCs after radical resection of esophageal cancer,and a decision tree prediction model for postoperative PPCs was constructed.Receiver operating characteristic(ROC)curve was used to analyze the value of related factors in predicting the occurrence of PPCs after radical resection of esophageal cancer.Results Univariate analysis showed that age,albumin/fibrinogen ratio,neutrophil/lymphocyte ratio,preoperative respiratory preparation,and drainage volume on the first day after surgery were associated with the occurrence of PPCs after radical resection of esophageal cancer(P＜0.05).Multivariate logistic regression analysis indicated that age,albumin/fibrinogen ratio and drainage volume on the first day after surgery were independent influencing factors for the occurrence of PPCs after radical resection of esophageal cancer(P＜0.05).The decision tree model identified drainage volume on the first day after surgery,albumin/fibrinogen ratio,age and neutrophil/lymphocyte ratio as predictive factors.The incidence rate of PPCs in the group without preoperative respiratory preparation was significantly higher than that in the group with preoperative respiratory preparation(62.5％vs.37.5％,P＜0.05).A drainage volume of 246.59 ml on the first day after surgery was the optimal cutoff value for predicting the occurrence of PPCs after radical resection of esophageal cancer,and specificity was 93.04％,sensitivity was 87.5％,area under ROC curve(AUC)was 0.958,95％CI was 0.911-0.984.Moreover,the incidence rate of PPCs in patients with a drainage volume≤246.59 ml on the first day after surgery was significantly higher than that in patients with a drainage volume＞246.59 ml(77.78％vs.3.60％,P＜0.01).Conclusion Preoperative airway preparation and postoperative drainage volume are closely related to the occurrence of postoperative pulmonary complications(PPCs)after thoracoscopic radical surgery for esophageal cancer.Therefore,targeted measures should be taken for airway preparation before surgery,and changes in the patient's condition should be closely monitored after surgery to accurately determine the timing of drainage tube removal,which plays an important role in effectively preventing and treating PPCs.

Objective To study the relationship between the OATP1B1 521T ＞ C genetic polymorphism and essential hypertension.Methods 164 essential hypertension subjects and 159 normotensive subjects were detected by the TaqMan-MGB probe real-time fluorescence quantitative PCR,and the results were compared with those of DNA sequencing.Results The frequencies of T/C genotype and C allele of OATP1B1 521T ＞ C gene of the essential hypertension subjects were obviously lower than those of the normotensive subjects(T/C genotype:0.16 vs 0.25,P ＜0.05 ;C allele:0.10 vs 0.17,P ＜0.05),The difference was significant.Binary logistic stepwise regression analysis was used for evaluatine the risk factors of essential hypertension,there was significant relationship between OATP1 B1 52IT ＞ C gene polymorphism and essential hypertension.Conclusion The SLCO1 B1 521T ＞ C variant was common in Chinese essential hypertension population,but the difference of frequency of SLCO1B1 52IT ＞ Cmuton between the essential hypertension patients and the normotensive controls was of obviously statistical significance,which indicates that the SLCO1B1521T ＞ C variant maybe associate with essential hypertension.

Objective To evaluate the safety and efficacy of Holmium laser resection for primary non-muscle invasive bladder cancer (HoLRBt) compared with transurethral resection of bladder tumor (TURBt). Methods Data of 212 patients with primary non-muscle invasive bladder cancer were collected retrospectively. The patients were divided into HoLRBt group(n= 101) and TURBt group (n= 111). The patients in each group were stratified into 3 risk groups (low, intermediate and high risk) according to prognostic factors for recurrence based on EAU guideline. Then, the safety of HoLRBt and TURBt groups were compared, concerning the intraoperative complications and postoperative recovery. Efficacy indicated by recurrence-free survival of the 2 groups was analyzed and compared by Kaplan-Meier technique. Results Patients' demographics including age, gender, tumor characteristics, and recurrence risk of tumor between the 2 groups were comparable(P＞0.05). No obturator nerve reflex occurred in the HoLRBt group. Meanwhile, 7 out of 111 patients in the TURBt group experienced this complication resulted bladder perforation in 3 patients. The proportion of patients needing postoperative bladder irrigation in the HoLRBt group was lower compared to the TURBt group (P＜0.05). HoLRBt was associated with shorter postoperative catheter drainage period (P＜0.05). The mean postoperative follow-up was 34 months (range 18 to 43). Recurrence-free survival after HoLRBt was similar with that of TURBt (P = 0. 283). Conclusions Compared with TURBt, HoLRBt is a feasible, safe and effective alternative for the management of primary non-muscle invasive bladder cancer with similar therapeutic efficacy and fewer perioperative complications.HoLRBt can be widely used in clinical practice in the treatment of primary non-muscle invasive bladder cancer.