Objective To explore the curative effect of pedicled retrograde posterior leg myocutaneous flap in patients with ankle soft tissue defect,and analyze its related factors on patients'sensory function.Methods The data of 120 patients with ankle soft tissue defect who were treated in our hospital from January 2015 to January 2022 and followed up for one year after operation were selected.Among them,60 cases were repaired with pedicled posterior leg myocutaneous flap(group A),40 were repaired with medial foot flap(group B)and 40 were repaired with ankle epithelial flap(group C).The healing(flap survival,infection,appearance,texture),sensory function,appearance satisfaction,Baird-Jackson score and complications of patients with ankle soft tissue defect in each group were compared.Results There was no difference in baseline data among the groups(P>0.05).Patients with ankle soft tissue defect in each group were observed for one year after flap repair.The survival rate of flap in group A was higher than that in group B and C,and the difference was statistically significant(P<0.05).There was no significant difference in infection,appearance,texture and walking function among the groups(P>0.05).After flap repair,the sensory function score of group A was better than that of group B and C,and the difference was statistically significant(P<0.05).The appearance satisfaction of group A was higher than that of group B and C,showing statistical significance(P<0.05).There was no difference in complications after flap repair in each group(P>0.05).Conclusion Skin flap should be chosen according to the area,shape and characteristics of the skin flap for patients with ankle soft tissue defect,and pedicled retrograde posterior leg myocutaneous flap has better curative effect,higher survival rate and higher excellent and good rate of ankle function.It is more helpful for limb function recovery of patients with ankle soft tissue defect.

Kidney cancer usually requires multidisciplinary individualized treatments. No matter what kind of treatment, drugs are essential. According to the "six-step process" (prescription legitimacy review, patient basic information evaluation review, treatment protocol review, organ function and laboratory index review, pretreatment review, and unconventional prescription review) in prescription review proposed by the anti-tumor drug prescription review expert group and referring to domestic and foreign kidney cancer guidelines and drug instructions in recent years, this consensus selects 9 targeted drugs and 4 immunotherapeutic drugs that are currently commonly used in China and elaborates the key review points in patient basic information evaluation review, treatment protocol review, and organ function and laboratory index review of kidney cancer drug treatment, in order to provide reference for clinical front-line pharmacists to review prescriptions of kidney cancer patients and promote rational drug use in clinic.

Kidney cancer usually requires multidisciplinary individualized treatments. No matter what kind of treatment, drugs are essential. According to the "six-step process" (prescription legitimacy review, patient basic information evaluation review, treatment protocol review, organ function and laboratory index review, pretreatment review, and unconventional prescription review) in prescription review proposed by the anti-tumor drug prescription review expert group and referring to domestic and foreign kidney cancer guidelines and drug instructions in recent years, this consensus selects 9 targeted drugs and 4 immunotherapeutic drugs that are currently commonly used in China and elaborates the key review points in patient basic information evaluation review, treatment protocol review, and organ function and laboratory index review of kidney cancer drug treatment, in order to provide reference for clinical front-line pharmacists to review prescriptions of kidney cancer patients and promote rational drug use in clinic.

Objective Investigate the effect of EC50 of propofol target-injection in the different TCM (traditional Chinese medicine) physique types of patients who are in unconscious phase. Methods Depend on the standard protocol of TCM physique types sort and determination, we sorted 60 patients into three groups:Ping He (group A), Yang Xu (group B) and Yin Xu (group C), 20 patients per group. We applied the sequential experiment to measure the minimal EC50 and NI values of propofol when the patients were in the unconscious phase. Results The EC50 of propofol of group A, B and C are 3.85 μg/mL, 4.12 μg/mL and 3.43 μg/mL respectively. 95% confidence intervals of group A, B and C are 3.64 ~ 4.07 μg/mL, 3.92 ~ 4.33μg/mL and 3.26 ~ 3.60 μg/mL respectively. Conclusion There is a correlation between the different TCM physique types and the dosage of propofol target-injection.