Peri-implant keratinized mucosa (PIKM) augmentation refers to surgical procedures aimed at increasing the width of PIKM. Consensus reports emphasize the necessity of maintaining a minimum width of PIKM to ensure long-term peri-implant health. Currently, several surgical techniques have been validated for their effectiveness in increasing PIKM. However, the selection and application of PIKM augmentation methods may present challenges for dental practitioners due to heterogeneity in surgical techniques, variations in clinical scenarios, and anatomical differences. Therefore, clear guidelines and considerations for PIKM augmentation are needed. This expert consensus focuses on the commonly employed surgical techniques for PIKM augmentation and the factors influencing their selection at second-stage surgery. It aims to establish a standardized framework for assessing, planning, and executing PIKM augmentation procedures, with the goal of offering evidence-based guidance to enhance the predictability and success of PIKM augmentation.
Humans ; Consensus ; Dental Implants ; Mouth Mucosa/surgery* ; Keratins

Objective To investigate the situation of HIV infection and epidemiological characteristics among voluntary blood donors and pre-transfusion patients in Yuxi prefecture between 2010 and 2021.Methods Da-te collected with the HIV/AIDS Case Reporting Cards and original record of blood station,HIV antibody positive rate,the demographic characteristics,and epidemiological data of blood donors and pre-transfusion patients,were analyzed accordingly,the related date were statistically analyzed.Results The HIV antibody positive ratio were 5.56? and 2.01? among pre-transfusion patients and voluntary blood donors(P<0.001),showing an downward trend year after year.The HIV-positive detection rate among blood donors aged<25 years was significantly higher at 3.72‰ compared to 1.60‰ for those aged≥25 years(P=0.003).Among HIV-positive blood recipients,the proportion of individuals aged 15-24 years(34.62%)was markedly higher than that among blood donors(1.96%),whereas no donors were aged≥50 years compared to 23.53%of recipients(P<0.001).Farmers showed a significantly higher HIV detection rate(3.18‰)than students(2.66‰)and other occupations(1.60‰)(P=0.041).Similarly,individuals with high school education or below showed a higher detection rate(2.52‰)than those with high school education or above(1.45‰)(P=0.045).Among HIV-positive cases,blood donors had a higher proportion of HIV-infected individuals(84.62%)versus AIDS cases(15.38%),whereas the recipients showed the opposite trend:41.18%HIV-infected versus 58.82%AIDS cases(P<0.001).Conclusion In recent years,the HIV positive detection rate in Yuxi area has shown a downward trend,but the occurrence of HIV in Yuxi area is characterized by youthfulness and low education.Among them,HIV infected individuals through same-sex contact account for an important reason for HIV infection.

Objective To investigate the expression of LncRNA RMST in gastric cancer and its value in diagnosis and prognosis.Methods Tumor and adjacent normal tissues were collected and analyzed from 92 gastric cancer patients.The expression of LncRNA RMST in these tissues was measured using RT-qPCR.ROC curve analysis was performed to evaluate the diagnostic value of LncRNA RMST for gastric cancer.Survival curves were plotted to assess the prognostic significance of LncRNA RMST in gastric cancer.Results LncRNA RMST expression was significantly lower in gastric cancer tissues than in normal tissues.Further analysis revealed that LncRNA RMST expression levels decreased progressively with advancing cancer stages and were significantly correlated with tumor size,TNM staging,and lymph node metastasis(P<0.05),with no significant correlation with patient age or gender.Additionally,ROC curve analysis indicated that LncRNA RMST has substantial diagnostic value in gastric cancer,with AUC of 0.76(95%CI:0.69～0.83,P<0.01),sensitivity of 70.31%,and specificity of 71.56%.Survival analysis showed that patients with high LncRNA RMST expression had significantly higher overall survival rates than those with low expression.Conclusion LncRNA RMST plays a critical role in the occurrence,progres-sion,and prognosis of gastric cancer.It may serve as a potential biomarker for the diagnosis and prognosis of gastric cancer,offering new insights for clinical screening and therapeutic strategies.

Objective To investigate the expression of LncRNA RMST in gastric cancer and its value in diagnosis and prognosis.Methods Tumor and adjacent normal tissues were collected and analyzed from 92 gastric cancer patients.The expression of LncRNA RMST in these tissues was measured using RT-qPCR.ROC curve analysis was performed to evaluate the diagnostic value of LncRNA RMST for gastric cancer.Survival curves were plotted to assess the prognostic significance of LncRNA RMST in gastric cancer.Results LncRNA RMST expression was significantly lower in gastric cancer tissues than in normal tissues.Further analysis revealed that LncRNA RMST expression levels decreased progressively with advancing cancer stages and were significantly correlated with tumor size,TNM staging,and lymph node metastasis(P<0.05),with no significant correlation with patient age or gender.Additionally,ROC curve analysis indicated that LncRNA RMST has substantial diagnostic value in gastric cancer,with AUC of 0.76(95%CI:0.69～0.83,P<0.01),sensitivity of 70.31%,and specificity of 71.56%.Survival analysis showed that patients with high LncRNA RMST expression had significantly higher overall survival rates than those with low expression.Conclusion LncRNA RMST plays a critical role in the occurrence,progres-sion,and prognosis of gastric cancer.It may serve as a potential biomarker for the diagnosis and prognosis of gastric cancer,offering new insights for clinical screening and therapeutic strategies.

Objective To investigate the job burnout of medical staff during long voyage in a navy warship troop and its influencing factors.Methods A total of 141 medical staff,who participated in a long voyage between January 2021 and December 2021,were consecutively included for surveys about basic information,job burnout,sleep quality,and regulation mode.Univariate and multivariate analyses were used to explore influencing factors for job burnout.Results The proportion of mild and below job burnout and moderate to severe job burnout in the cohort was 45.39%and 54.61%,respectively.Univariate analysis showed that married status,Master's or Doctor's degree,moderate to heavy workload,no psychological training experience,sleep disorder and low-exercise regulation mode were significant influencing factors for job burnout(P<0.05).Multivariate analysis showed that married status,Master's or Doctor's degree,sleep disorder and low-exercise and high-evaluation regulation mode were independent risk factors for job burnout(P<0.05).However,psychological training experience was considered to be a significant protective factor(P= 0.021).Conclusion Medical staff in a navy warship troop experiences severe job burnout during long voyage.The people who are married,have a Master's or Doctor's degree,have sleep disorder and low-exercise and high-evaluation regulation mode are more likely to experience job burnout,which should be paid more attention to.

Objective:To investigate the predictive value of different body obesity measures for non-alcoholic fatty liver disease (NAFLD).Methods:It was a cross-sectional study. The present study was a case-control study involving 553 subjects who underwent physical examination from January to April 2022. The subjects were divided into NAFLD group ( n=321 cases) and control group ( n=232 cases) according to abdominal ultrasound imaging parameters. All subjects completed a general information questionnaire, liver ultrasound examination, serum biochemical indices and physical measurements. Logistic regression model was used to analyze the correlation between human obesity measures (neck circumference, triceps skinfold thickness (TSF),body mass index (BMI), waist-to-hip ratio, lipid accumulation index (LAP), visceral fat index (VAI), body roundness index (BRI) and a body shape index (ABSI)) and NAFLD. Receiver operating characteristic (ROC) curve and area under the curve (AUC) were used to evaluate the predictive value of single and combined measures of obesity for NAFLD. Results:The subjects were stratified by gender, and the quartile levels of BMI, neck circumference, TSF, waist-to-hip ratio, LAP, VAI and BRI were all correlated with NAFLD in both male and female (all P<0.05). After further adjustment for confounding factors, compared with those in group Q 1, group Q 4 of the above-mentioned indexes still had higher odds ratios ( P<0.05). The AUC value of LAP in predicting NAFLD was the largest in both men and women, which was 0.836(0.788-0.876) and 0.885(0.839-0.921), and the cut-off value was 41.93 and 33.27, respectively. There was no significant difference in AUC of ROC predicting NAFLD among LAP, BRI and BMI ( P>0.05). The AUC of ABSI in predicting NAFLD was less than 0.7(namely 0.584(0.525-0.641) and 0.679(0.618-0.735) in men and women, respectively), which indicated poor predictive performance for NAFLD. In the pairwise combination index, the AUC of ROC predicting NAFLD with TSF+LAP in male was the largest, which was 0.864(0.819-0.901), and there was statistical significance when compared with BRI (AUC=0.818(0.769-0.860)) and BMI (AUC=0.816(0.767-0.858)) ( P<0.05), but there was no statistical significance when compared with LAP (AUC=0.836(0.788-0.876)) ( P>0.05). The AUC of ROC predicting NAFLD with VAI+LAP in women was the largest, it was 0.894(0.849-0.928), there was statistical significance when compared with BMI (AUC=0.849(0.799-0.890)) ( P<0.05), but there was no statistical significance when compared with LAP (AUC=0.885(0.839-0.921)) and BRI (AUC=0.870(0.822-0.908)) ( P>0.05). Conclusion:BMI, neck circumference, TSF, waist-to-hip ratio, LAP, VAI and BRI all have good predictive value for NAFLD.

Objective:To analyze the molecular mechanism of Zhenqi Fuzheng Capsules in the adjuvant treatment of AIDS by network pharmacology method and molecular docking technology.Methods:The active components and targets of Zhenqi Fuzheng Capsules were obtained through TCMSP, and the AIDS-related targets were obtained through GeneCards, OMIM and DrugBank databases. The intersection target PPI network was constructed through STRING 11.5 database, and Cytoscape 3.9.1 software was used for network topology analysis; Metascape database was used for GO function and KEGG pathway enrichment analysis of core targets; Cytoscape 3.9.1 was used to construct Zhenqi Fuzheng Capsules component-target-pathway network; Autodock Tools software was used to carry out molecular docking of core targets and active components.Results:Totally 31 active components and 180 targets of Zhenqi Fuzheng Capsules were screened out. TNF, IL6, AKT1, IL1B, TP53, VEGFA, RELA, EGFR and CASP3 were identified as the core targets. GO functional enrichment analysis obtained 1 436 biological processes, 53 cellular components, and 117 molecular functions. KEGG pathway enrichment analysis obtained 167 pathways, which were related to pathways in cancer, AGE-RAGE signaling pathway in diabetic complications, and IL-17 signaling pathway was closely related. Molecular docking results showed that core targets such as AKT1 and TNF had good binding activity to quercetin, kaempferol, and luteolin.Conclusion:The main active components of Zhenqi Fuzheng Capsules in the adjuvant treatment of AIDS are quercetin, kaempferol and luteolin, which may treat AIDS through the IL-17 signaling pathway.

Pulmonary blast injury has become the main type of trauma in modern warfare, characterized by externally mild injuries but internally severe injuries, rapid disease progression, and a high rate of early death. The injury is complicated in clinical practice, often with multiple and compound injuries. Currently, there is a lack of effective protective materials, accurate injury detection instrument and portable monitoring and transportation equipment, standardized clinical treatment guidelines in various medical centers, and evidence-based guidelines at home and abroad, resulting in a high mortality in clinlcal practice. Therefore, the Trauma Branch of Chinese Medical Association and the Editorial Committee of Chinese Journal of Trauma organized military and civilian experts in related fields such as thoracic surgery and traumatic surgery to jointly develop the Clinical treatment guideline for pulmonary blast injury ( version 2023) by combining evidence for effectiveness and clinical first-line treatment experience. This guideline provided 16 recommended opinions surrounding definition, characteristics, pre-hospital diagnosis and treatment, and in-hospital treatment of pulmonary blast injury, hoping to provide a basis for the clinical treatment in hospitals at different levels.

In view of the significant changes in the prevention and control of COVID-19 at home and abroad, "external prevention of importation and internal prevention of rebound" has become the focus of prevention and control of the epidemic in China. Due to the limitation of testing sites, equipment and reaction time, traditional detection methods cannot meet the needs of real-time and rapid detection of 2019-nCoV. Point-of-care testing (POCT) is rapid, portable and flexible. It plays an increasingly important role in the rapid detection and screening of 2019-nCoV. Here, we review the current status and research progress of POCT for 2019-nCoV in terms of antigens, specific antibodies and nucleic acids, in order to provide reference for epidemic prevention and control and clinical management.

Anorexia nervosa (AN) is a type of eating disorder characterized by severe malnutrition and abnormally low body weights, resulting from patients′ intentionally strict restrictions on eating. Patients with AN often have body image disturbances and are comorbid with psychiatric symptoms, such as obsessive-compulsive symptoms, depression, anxiety, and so forth. These patients may suffer from severe malnutrition, amenorrhea, and even death since they refuse to eat. As a mental disorder with a high mortality rate, there is still no specific medicine to treat AN. This case is a female patient with AN treated with bilateral anterior capsulotomy (BACA) combined with deep brain stimulation (DBS). The treatment efficacy was evident. Before the operation, her body mass index (BMI) was only 12.22 kg/m 2. She had repeated binge-eating-emetic behaviors, severe obsessive-compulsive symptoms, anxiety and depression, suicide attempt, severe malnutrition, amenorrhea, recurrent infections, and so forth. At the 3-month follow-up after the operation, the patient was emotionally stable and had a BMI of 19.40 kg/m 2. The reducing rates of the total scores of the Hamilton Anxiety Scale (HAMA), the 24-item Hamilton Depression Scale (HAMD 24), and the Yale-Brown Obsessive-Compulsive Scale (Y-BROW) were 64%, 64%, and 52%, respectively. This study found that BACA combined with DBS surgery can rapidly and effectively improve the prognosis of patients with the binge-eating/purging subtype of AN.