Coronavirus disease 2019(COVID-19)is a respiratory syndrome caused by severe acute respiratory syn-drome coronavirus 2(SARS-CoV-2).Once SARS-CoV-2 was detected in Wuhan(Hubei Province,China),it rap-idly spread widely across China and the world,posing a serious threat to global health and the economy.With the development of Artificial Intelligence(AI)technology and the openness and application of open-source software,tremendous progress has been achieved in the quantitative study of chest radiology for COVID-19,enabling the quantitative dataization of radiological image data,which adds a powerful indicator to the prognosis study of COV-ID-19.Therefore,we reviewed the current literature on the factors predicting the severity and prognosis of COV-ID-19,and summarized demographic,laboratory and radiological factors to help with risk stratification and prog-nosis assessment for COVID-19 patients and assist in their clinical management and treatment.

Objective:To investigate the effects of short-chain fatty acids(SCFAs)on the proliferation,migration and adipogenic ability of dental pulp stem cells(DPSCs).Methods:Dental pulp stem cells were extracted from young permanent teeth and treated with sodium acetate and sodium propionate.CCK-8 assay was used to detect the activity of DPSCs.Immunofluorescence staining was used to detect the proliferation of DPSCs.The scratch test was employed to assess the migratory activity of DPSCs,alizarin red staining was utilized to evaluate the capacity for calcification nodule formation,and red oil O staining was applied to determine the adipogenic potential of DPSCs.Results:The acetate and propionate significantly enhanced the viability,promoted the proliferation,migration and adipogenic differentiation of DPSCs.The osteogenic differentiation ability of DPSCs,which were with sodium acetate and sodium propionate,was observed.There was no significant difference in the osteogenic differentiation ability of DPSCs compared to the control group.Conclusion:The findings suggest that SCFAs have the potential to enhance the viability,proliferation,migra-tion,and adipogenic differentiation of dental pulp stem cells,thereby promoting their application in pulp repair and tissue engineering.

Body weight abnormalities, including overweight, obesity, and underweight, have become a dual public health challenge in Chinese adults: overweight and obesity lead to a variety of chronic complications, while underweight increases the risks of malnutrition, sarcopenia, and organ dysfunction. To systematically address these issues, multidisciplinary experts in endocrinology, sports science, nutrition, and psychiatry from various regions have held multiple weight management seminars. Based on the latest epidemiological data and clinical evidence, they expanded the guideline to include assessment and intervention strategies for underweight, in addition to the core content of obesity management. This guideline outlines the etiological mechanisms, evaluation methods, and multidimensional management strategies for overweight and obesity, covering key areas such as diagnosis and assessment, medical nutrition therapy, exercise prescription, pharmacological intervention, and psychological support. It is intended to provide a scientific and standardized approach to weight management across the adult population, aiming to curb the rising prevalence of obesity, mitigate complications associated with abnormal body weight, and improve nutritional status and overall quality of life.

Objective:To investigate the effects of short-chain fatty acids(SCFAs)on the proliferation,migration and adipogenic ability of dental pulp stem cells(DPSCs).Methods:Dental pulp stem cells were extracted from young permanent teeth and treated with sodium acetate and sodium propionate.CCK-8 assay was used to detect the activity of DPSCs.Immunofluorescence staining was used to detect the proliferation of DPSCs.The scratch test was employed to assess the migratory activity of DPSCs,alizarin red staining was utilized to evaluate the capacity for calcification nodule formation,and red oil O staining was applied to determine the adipogenic potential of DPSCs.Results:The acetate and propionate significantly enhanced the viability,promoted the proliferation,migration and adipogenic differentiation of DPSCs.The osteogenic differentiation ability of DPSCs,which were with sodium acetate and sodium propionate,was observed.There was no significant difference in the osteogenic differentiation ability of DPSCs compared to the control group.Conclusion:The findings suggest that SCFAs have the potential to enhance the viability,proliferation,migra-tion,and adipogenic differentiation of dental pulp stem cells,thereby promoting their application in pulp repair and tissue engineering.

Coronavirus disease 2019(COVID-19)is a respiratory syndrome caused by severe acute respiratory syn-drome coronavirus 2(SARS-CoV-2).Once SARS-CoV-2 was detected in Wuhan(Hubei Province,China),it rap-idly spread widely across China and the world,posing a serious threat to global health and the economy.With the development of Artificial Intelligence(AI)technology and the openness and application of open-source software,tremendous progress has been achieved in the quantitative study of chest radiology for COVID-19,enabling the quantitative dataization of radiological image data,which adds a powerful indicator to the prognosis study of COV-ID-19.Therefore,we reviewed the current literature on the factors predicting the severity and prognosis of COV-ID-19,and summarized demographic,laboratory and radiological factors to help with risk stratification and prog-nosis assessment for COVID-19 patients and assist in their clinical management and treatment.

Body weight abnormalities, including overweight, obesity, and underweight, have become a dual public health challenge in Chinese adults: overweight and obesity lead to a variety of chronic complications, while underweight increases the risks of malnutrition, sarcopenia, and organ dysfunction. To systematically address these issues, multidisciplinary experts in endocrinology, sports science, nutrition, and psychiatry from various regions have held multiple weight management seminars. Based on the latest epidemiological data and clinical evidence, they expanded the guideline to include assessment and intervention strategies for underweight, in addition to the core content of obesity management. This guideline outlines the etiological mechanisms, evaluation methods, and multidimensional management strategies for overweight and obesity, covering key areas such as diagnosis and assessment, medical nutrition therapy, exercise prescription, pharmacological intervention, and psychological support. It is intended to provide a scientific and standardized approach to weight management across the adult population, aiming to curb the rising prevalence of obesity, mitigate complications associated with abnormal body weight, and improve nutritional status and overall quality of life.

ObjectiveTo investigate the value of aspartate aminotransferase-to-platelet ratio index （APRI） and platelet-albumin-bilirubin （PALBI） score in predicting the risk of esophagogastric variceal bleeding in patients with liver cirrhosis. MethodsA total of 119 patients with liver cirrhosis who were admitted to The First Affiliated Hospital of Soochow University from May 2021 and June 2022 were enrolled， and clinical data， routine blood test results， serum biochemistry， and coagulation test results were collected from all patients. According to the presence or absence of esophagogastric variceal bleeding， the patients were divided into non-bleeding group with 59 patients and bleeding group with 60 patients， and a comparative analysis was performed for the two groups. The independent samples t-test was used for comparison of normally distributed continuous data between two groups， and the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between two groups； the chi-squared test or the Fisher’s exact test was used for comparison of categorical data between groups. The multivariate Logistic regression analysis was used to identify the independent risk factors for esophagogastric variceal bleeding in patients with liver cirrhosis and establish a nomogram predictive model. ResultsThe male patients accounted for 75.00% in the bleeding group and 40.68% in the non-bleeding group， and there was a significant difference in sex composition between the two groups （χ²=14.384， P<0.001）. Chronic hepatitis B was the main etiology in both the bleeding group and the non-bleeding group （53.33% vs 38.98%）， and there was no significant difference in composition ratio between the two groups （χ²=2.464， P=0.116）. Compared with the non-bleeding group， the bleeding group had a significantly higher activity of AT-IIIA （t=3.329， P=0.001） and significantly lower levels of PLT， TBil， Ca， TC， and TT （all P<0.05）. There were significant differences in APRI and PALBI between the two groups （χ²=6.175 and 19.532， both P<0.05）. The binary logistic regression analysis showed that APRI （odds ratio ［OR］=0.309， 95% confidence interval ［CI］： 0.109‍ ‍—‍ ‍0.881， P=0.028）， PALBI （OR=7.667， 95%CI： 2.005‍ ‍—‍ ‍29.327， P=0.003）， Ca （OR=0.001， 95%CI： 0.000‍ ‍—‍ ‍0.141， P=0.007）， TC （OR=0.469， 95%CI： 0.226‍ ‍—‍ ‍0.973， P=0.042）， and TT （OR=0.599， 95%CI： 0.433‍ ‍—‍ ‍0.830， P=0.002） were independent influencing factors for esophagogastric variceal bleeding in liver cirrhosis. A nomogram model was established based on the above factors and had an index of concordance of 0.899 and a well-fitted calibration curve. ConclusionAPRI and PALBI have a good value in predicting esophagogastric variceal bleeding in patients with liver cirrhosis， and the nomogram model established based on this study can predict the incidence rate of esophagogastric variceal bleeding in patients with liver cirrhosis.

Objective To compare the effect of routine speech training and computer-assisted training on post-stroke dysarthria. Methods From March,2021 to April,2023,72 patients with post-stroke dysarthria in Beijing Bo'ai Hospital were ran-domly divided into control group(n=36)and experimental group(n=36).Both groups received routine rehabili-tation,while the control group received routine speech training,and the experimental group received computer-assisted training,for four weeks.They were assessed with modified Frenchay Dysarthria Assessment(m-FDA)and Speech Intelligibility(SI)before and after intervention. Results Eight cases in the control group and one case in the experimental group dropped down.The scores of m-FDA and SI improved in both groups after treatment(|Z|＞4.183,P＜0.001),and there was no significant difference between two groups(|Z|＜1.598,P＞0.05).Noninferiority of m-FDA was found between two groups(|t|＞3.656,P＜0.001). Conclusion Computer-assisted training could improve the speech function of patients with post-stroke dysarthria,simi-lar to routine speech training.

Myocardial fibrosis is one of the important pathological mechanisms in cardiac diseases. Non-invasive evaluation of fibrosis is of great clinical significance. Fibroblast activation protein (FAP) is selectively expressed in the membrane of activated fibroblasts. Radionuclide labeled FAP inhibitors (FAPI) serve as novel imaging agents, which specifically target to the process of fibrotic remodeling. This article reviews the research progress of radionuclide labeled FAPI PET imaging in cardiac diseases.

ObjectiveTo observe the effect of music therapy on cognitive function, motor function, and activities of daily living (ADL) of patients with post-stroke cognitive impairment. MethodsFrom December, 2020 to July, 2022, 48 patients with post-stroke cognitive impairment in Beijing Bo'ai Hospital were enrolled and randomly divided into control group (n = 24) and experimental group (n = 24). Both groups received conventional medication, nursing, and conventional rehabilitation, while the experimental group received music therapy additionally, for eight weeks. Before and after intervention, the cognitive function was assessed by Loewenstein Occupational Therapy Cognitive Assessment (LOTCA), and motor function and ADL were assessed with Fugl-Meyer Assessment (FMA) and modified Barthel Index (MBI), respectively. ResultsSix cases in the control group dropped down. The increase in the scores of LOTCA and FMA was more in the experimental group than in the control group (t > 2.665, P < 0.05), however, no significant difference was found in the increase of MBI score between two groups. ConclusionMusic therapy could improve the cognitive function and motor function of patients with post-stroke cognitive impairment.