Objective To analyze the epidemiological characteristics and disease burden of malignant tumors in Shijiazhuang in 2021. Methods Based on data from the Shijiazhuang City Cancer Registry, incidence and mortality indicators for malignant tumors were calculated, including crude rates, age-standardized rates (using Chinese and world standard populations), and the cumulative rate (0−74 years old), to describe the epidemiological profile. The disability-adjusted life years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs) were calculated to estimate the disease burden of malignant tumors. Results In 2021, a total of 13250 new cancer cases were recorded. The crude incidence rate was 275.50/10⁵, the ASR China was 177.17/10⁵, the ASR world was 172.11/10⁵, and the cumulative rate (0–74 years old) was17.77%. The age-specific incidence of malignant tumors reached its peak in the age group of 80–84 years old. A total of 7165 deaths were noted, and the crude mortality rate was 148.98/10⁵. The ASR China was 85.13/10⁵, the ASR world was 84.52/10⁵, and the cumulative rate (0–74 years old) was 9.49%. The age-specific mortality of malignant tumors reached its peak in the age group of above 85 years old. Lung cancer and breast cancer were the most common malignant tumors in males and females. The DALYs of malignant tumors were 87725.29 person-years, and the DALY rate was 18.24‰. YLL was 85392.09 person-years (97.34%), and YLD was 2333.19 person-years (2.66%). Lung cancer had the heaviest disease burden with DALY of 22687.12 person-years, accounting for 25.86% of all malignant tumors, followed by gastric, liver, colorectal and esophageal cancers. Conclusion Cancers of the lung, liver, female breast, stomach, and colorectum are the major health threats in Shijiazhuang. Malignant tumor brings heavy burden to residents of Shijiazhuang city. To decrease the disease burden of cancer, scholars should pay more attention, and implement preventive measures early.

Myxedema coma is a rare condition, typically arising from long-standing, untreated hypothyroidism and triggered by factors such as infection, hypothermia, or severe illness. This report details a successfully treated case of myxedema coma with cardiac attest, accompanied by a literature review, to enhance clinical awareness and improve the diagnosis and management of this critical condition.

Body weight abnormalities, including overweight, obesity, and underweight, have become a dual public health challenge in Chinese adults: overweight and obesity lead to a variety of chronic complications, while underweight increases the risks of malnutrition, sarcopenia, and organ dysfunction. To systematically address these issues, multidisciplinary experts in endocrinology, sports science, nutrition, and psychiatry from various regions have held multiple weight management seminars. Based on the latest epidemiological data and clinical evidence, they expanded the guideline to include assessment and intervention strategies for underweight, in addition to the core content of obesity management. This guideline outlines the etiological mechanisms, evaluation methods, and multidimensional management strategies for overweight and obesity, covering key areas such as diagnosis and assessment, medical nutrition therapy, exercise prescription, pharmacological intervention, and psychological support. It is intended to provide a scientific and standardized approach to weight management across the adult population, aiming to curb the rising prevalence of obesity, mitigate complications associated with abnormal body weight, and improve nutritional status and overall quality of life.

Objective To explore the efficacy and action mechanism of a novel phenothiazine derivative,DA414,in rats with intracerebral hemorrhage(ICH).Methods Male Sprague-Dawley(SD)rats(aged 8～10 weeks,weighing 250～300 g)were randomly divided into sham operation,model,and low and high dose DA414 groups[5 and 10 mg/(kg·d)],with 20 animals per group.The size and extent of injury in the ICH area were measured by magnetic resonance imaging(MRI)and histopathological slices.Neurological function was evaluated with a behavioral grading system.Western blotting was used to detect the expression of ferroptosis-related factor,glutathione peroxidase 4(GPX4).Multiplex immunohistochemistry was employed to quantitatively evaluate microglial activation in perihematomal tissue.RT-qPCR was applied to measure the mRNA expression levels of NLRP3 inflammasome components(NLRP3,Caspase-1,IL-1β),pro-inflammatory(IL-18,TLR4,IL-6,TNF-α)and anti-inflammatory cytokines(IL-4,IL-10).The integrity of the blood-brain barrier(BBB)was assessed by Evans blue staining,and the biosafety of DA414 for the liver,kidneys and heart was assessed by HE staining and clinical biochemical tests.Results DA414 significantly promoted the absorption of hematoma,reduced neuronal injury,and improved neurological function scores.DA414 significantly up-regulated the ferroptosis regulatory factor GPX4(P<0.01),and also significantly inhibited the activation of microglia after ICH(P<0.001).RT-qPCR indicated that DA414 treatment resulted in down-regulation of mRNA expression in the inflammasome pathway(NLRP3,Caspase-1,IL-1β,all P<0.01)and pro-inflammatory cytokines(TLR4,IL-6,both P<0.05;IL-18,TNF-α,both P<0.01)and up-regulation of anti-inflammatory cytokines(IL-4,IL-10,both P<0.05),suggesting that DA414 exerts its neuroprotective effect probably by regulating ferroptosis and inflammation.Safety assessment revealed that DA414 had no significant effect on BBB integrity or damage to the liver,kidneys,and heart in rats.Conclusion DA414 exerts significant neuroprotective effects in ICH model by targeted inhibition for ferroptosis and modulating inflammatory response.Our study provides an experimental foundation for ICH treatment.

Myxedema coma is a rare condition, typically arising from long-standing, untreated hypothyroidism and triggered by factors such as infection, hypothermia, or severe illness. This report details a successfully treated case of myxedema coma with cardiac attest, accompanied by a literature review, to enhance clinical awareness and improve the diagnosis and management of this critical condition.

Body weight abnormalities, including overweight, obesity, and underweight, have become a dual public health challenge in Chinese adults: overweight and obesity lead to a variety of chronic complications, while underweight increases the risks of malnutrition, sarcopenia, and organ dysfunction. To systematically address these issues, multidisciplinary experts in endocrinology, sports science, nutrition, and psychiatry from various regions have held multiple weight management seminars. Based on the latest epidemiological data and clinical evidence, they expanded the guideline to include assessment and intervention strategies for underweight, in addition to the core content of obesity management. This guideline outlines the etiological mechanisms, evaluation methods, and multidimensional management strategies for overweight and obesity, covering key areas such as diagnosis and assessment, medical nutrition therapy, exercise prescription, pharmacological intervention, and psychological support. It is intended to provide a scientific and standardized approach to weight management across the adult population, aiming to curb the rising prevalence of obesity, mitigate complications associated with abnormal body weight, and improve nutritional status and overall quality of life.

Objective:To automatically classify hypertensive heart disease (HHD) and hypertrophic cardiomyopathy (HCM) based on mul-titask learning algorithm using native T1 mapping images.Methods:A total of 203 patients admitted to Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University from January 2017 to December 2021 were enrolled, including 53 patients with HHD, 121 patients with HCM, and 29 patients with normal control (NC). Native T1 mapping images of all enrolled patients were acquired using MRI and processed by a multi-task learning algorithm. The classification performance of each model was validated using ten-fold crossover, confusion matrix, and receiver operator characteristic (ROC) curves. The Resnet 50 model based on the original images was established as a control.Results:The ten-fold crossover validation results showed that the MTL-1 024, MTL-64, and MTL-all models showed better performance in terms of area under the curve (AUC), accuracy, sensitivity, and specificity compared to the Resnet 50 model. In the classification task, the MTL-64 model showed the best performance in terms of AUC (0.942 1), while the MTL-all model reached the highest value in terms of accuracy (0.852 2). In the segmentation task, the MTL-64 model achieved the best results with the Dice coefficient (0.879 7). The confusion matrix plot showed that the MTL model outperforms the Resnet 50 model based on the original image in terms of overall performance. The ROC graphs of all MTL models were significantly higher than the original image input Resnet 50 model.Conclusions:Multi-task learning-based native T1 mapping images are effective for automatic classification of HHD and HCM.

Purpose: This study compared the efficacy of heat insulation between 5% dextrose and 0.9% saline in radiofrequency ablation (RFA). Accordingly, temperature variations and maximum temperatures were assessed at identical distances and heat field distributions. Methods: Cubes of porcine liver tissue, measuring 10 mm across, were selected to precisely align the ablation boundary with the tissue boundary. An 18-gauge electrode with a 7-mm tip was inserted into each cube (10 per group) in a stainless-steel cup containing 40 mL of 5% dextrose or 0.9% saline. Fixed ablation was performed for 3 minutes using continuous mode at 30 W, simulating the typical thermal environment during thyroid RFA. Real-time temperature measurements were recorded by sensors positioned 0, 1, 3, and 5 mm from the cube’s edge. A comparative analysis was conducted to assess the maximum temperature, temperature variation, and duration of temperatures exceeding 42℃. Results: In both groups, the temperature curve declined with increasing distance from the edge of the ablated tissue. However, 0.9% saline exhibited higher maximum temperatures at 1, 3, and 5 mm compared to 5% dextrose (1 mm: 44.55°C±5.25°C vs. 34.68°C±3.07°C; 3 mm: 39.64°C±2.53°C vs. 29.22°C±2.21°C; 5 mm: 38.86°C±2.14°C vs. 28.74°C±2.51°C; all P<0.001). Considering a nerve injury threshold of 42°C, the 0.9% saline also displayed a greater proportion of samples reaching this temperature and a longer duration of temperatures exceeding it (P<0.05). Conclusion The heat insulation efficacy of 5% dextrose at 1-5 mm exceeds that of 0.9% saline at identical distances and in a common thermal environment during thyroid RFA.

Purpose: This study compared the efficacy of heat insulation between 5% dextrose and 0.9% saline in radiofrequency ablation (RFA). Accordingly, temperature variations and maximum temperatures were assessed at identical distances and heat field distributions. Methods: Cubes of porcine liver tissue, measuring 10 mm across, were selected to precisely align the ablation boundary with the tissue boundary. An 18-gauge electrode with a 7-mm tip was inserted into each cube (10 per group) in a stainless-steel cup containing 40 mL of 5% dextrose or 0.9% saline. Fixed ablation was performed for 3 minutes using continuous mode at 30 W, simulating the typical thermal environment during thyroid RFA. Real-time temperature measurements were recorded by sensors positioned 0, 1, 3, and 5 mm from the cube’s edge. A comparative analysis was conducted to assess the maximum temperature, temperature variation, and duration of temperatures exceeding 42℃. Results: In both groups, the temperature curve declined with increasing distance from the edge of the ablated tissue. However, 0.9% saline exhibited higher maximum temperatures at 1, 3, and 5 mm compared to 5% dextrose (1 mm: 44.55°C±5.25°C vs. 34.68°C±3.07°C; 3 mm: 39.64°C±2.53°C vs. 29.22°C±2.21°C; 5 mm: 38.86°C±2.14°C vs. 28.74°C±2.51°C; all P<0.001). Considering a nerve injury threshold of 42°C, the 0.9% saline also displayed a greater proportion of samples reaching this temperature and a longer duration of temperatures exceeding it (P<0.05). Conclusion The heat insulation efficacy of 5% dextrose at 1-5 mm exceeds that of 0.9% saline at identical distances and in a common thermal environment during thyroid RFA.

Purpose: This study compared the efficacy of heat insulation between 5% dextrose and 0.9% saline in radiofrequency ablation (RFA). Accordingly, temperature variations and maximum temperatures were assessed at identical distances and heat field distributions. Methods: Cubes of porcine liver tissue, measuring 10 mm across, were selected to precisely align the ablation boundary with the tissue boundary. An 18-gauge electrode with a 7-mm tip was inserted into each cube (10 per group) in a stainless-steel cup containing 40 mL of 5% dextrose or 0.9% saline. Fixed ablation was performed for 3 minutes using continuous mode at 30 W, simulating the typical thermal environment during thyroid RFA. Real-time temperature measurements were recorded by sensors positioned 0, 1, 3, and 5 mm from the cube’s edge. A comparative analysis was conducted to assess the maximum temperature, temperature variation, and duration of temperatures exceeding 42℃. Results: In both groups, the temperature curve declined with increasing distance from the edge of the ablated tissue. However, 0.9% saline exhibited higher maximum temperatures at 1, 3, and 5 mm compared to 5% dextrose (1 mm: 44.55°C±5.25°C vs. 34.68°C±3.07°C; 3 mm: 39.64°C±2.53°C vs. 29.22°C±2.21°C; 5 mm: 38.86°C±2.14°C vs. 28.74°C±2.51°C; all P<0.001). Considering a nerve injury threshold of 42°C, the 0.9% saline also displayed a greater proportion of samples reaching this temperature and a longer duration of temperatures exceeding it (P<0.05). Conclusion The heat insulation efficacy of 5% dextrose at 1-5 mm exceeds that of 0.9% saline at identical distances and in a common thermal environment during thyroid RFA.